Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Klaus Klinder"'
Autor:
Yunhai Cui, Cyril Desevaux, Ines Truebenbach, Peter Sieger, Klaus Klinder, Alan Long, Achim Sauer
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1146 (2021)
Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involv
Externí odkaz:
https://doaj.org/article/450fe8cfeded4f9c92c2b29b6ac8c182
Publikováno v:
Pharmaceutics, Vol 11, Iss 11, p 595 (2019)
Movement of xenobiotic substances across the blood−brain barrier (BBB) is tightly regulated by various transporter proteins, especially the efflux transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP). Avoiding drug ef
Externí odkaz:
https://doaj.org/article/84ea435ab49f49b6880b1423e43d1294
Autor:
Alexandra Münster, Susanne Sommer, Diana Kúkeľová, Hannes Sigrist, Eliza Koros, Serena Deiana, Klaus Klinder, Tamara Baader-Pagler, Svenja Mayer-Wrangowski, Boris Ferger, Tom Bretschneider, Christopher R. Pryce, Wolfgang Hauber, Moritz von Heimendahl
Apathy, deficiency of motivation including willingness to exert effort for reward, is a common symptom in many psychiatric and neurological disorders, including depression and schizophrenia. Despite improved understanding of the neurocircuitry and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971a314290fac4cecbcef404ff0384c5
https://www.zora.uzh.ch/id/eprint/221202/
https://www.zora.uzh.ch/id/eprint/221202/
Autor:
Dennis Fiegen, Ralf Heilker, Herbert Nar, Iain Lingard, Klaus Klinder, Michael Wolff, Heike Neubauer, Jürgen Prestle, Francois Debaene, Gisela Schnapp, Frank H. Büttner, Sandra Handschuh, Markus Zeeb, Rainer Walter
Publikováno v:
Communications Chemistry, Vol 3, Iss 1, Pp 1-11 (2020)
The C-type lectin family member lectin-like oxidized LDL receptor-1 (LOX-1) has been object of intensive research. Its modulation may offer a broad spectrum of therapeutic interventions ranging from cardiovascular diseases to cancer. LOX-1 mediates u
Autor:
Peter Sieger, Cyril Desevaux, Ines Truebenbach, Klaus Klinder, Alan Long, Achim Sauer, Yunhai Cui
Publikováno v:
Pharmaceutics, Vol 13, Iss 1146, p 1146 (2021)
Pharmaceutics
Volume 13
Issue 8
Pharmaceutics
Volume 13
Issue 8
Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involv
Publikováno v:
Pharmaceutics, Vol 11, Iss 11, p 595 (2019)
Pharmaceutics
Volume 11
Issue 11
Pharmaceutics
Volume 11
Issue 11
Movement of xenobiotic substances across the blood&ndash
brain barrier (BBB) is tightly regulated by various transporter proteins, especially the efflux transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP). Avoidin
brain barrier (BBB) is tightly regulated by various transporter proteins, especially the efflux transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP). Avoidin
Autor:
Holger Fuchs, Naoki Ishiguro, Shinobu Suzuki, Yunhai Cui, Achim Sauer, Michitoshi Watanabe, Klaus Klinder, Clemens Braun, Atsushi Sakamoto, Tetsuya Terasaki
Publikováno v:
Molecular Pharmaceutics. 14:3436-3447
Transporters at the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) play a pivotal role as gatekeepers for efflux or uptake of endogenous and exogenous molecules. The protein expression of a number of them has already been
Autor:
Gaku Morinaga, Asami Saito, Roderich D. Süssmuth, Michelle Schaefer, Akiko Matsui, Daniel Bischoff, Klaus Klinder, Gerhard Schänzle
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S58
Autor:
Wolfgang Rist, Daniel Bischoff, Klaus Klinder, Paul Nicklin, Tom Bretschneider, Andreas H. Luippold, Helmut Romig
Publikováno v:
SLAS discovery : advancing life sciences RD. 22(4)
Autotaxin (ATX) is a promising drug target for the treatment of several diseases, such as cancer and fibrosis. ATX hydrolyzes lysophosphatidyl choline (LPC) into bioactive lysophosphatidic acid (LPA). The potency of ATX inhibitors can be readily dete
Publikováno v:
Neuropharmacology. 49:1220-1227
Neuropathic pain affects many patients, and treatment today is far from being perfect. Nav1.8 Na(+) channels, which are expressed by small fibre sensory neurons, are promising targets for novel analgesics. Na(+) channel blockers used today, however,