Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Klaus K. Orlinger"'
Autor:
Pedro Berraondo, Catarina Pinto, Sarah Schmidt, Henning Lauterbach, Timo Schippers, Josipa Raguz, Theresa Pölzlbauer, Mohamed Habbeddine, Sandra Rosskopf, Judith Strauß, Valentin Just, Katell Bidet Huang, Felix Stemeseder, Ethan Stewart, Jakub Jez, Klaus K. Orlinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Engineered arenavirus vectors have recently been developed to leverage the body’s immune system in the fight against chronic viral infections and cancer. Vectors based on Pichinde virus (artPICV) and lymphocytic choriomeningitis virus (a
Externí odkaz:
https://doaj.org/article/d6f7f53f92c1475190372c05efca000b
Autor:
Sandra S. Ring, Jovana Cupovic, Lucas Onder, Mechthild Lütge, Christian Perez-Shibayama, Cristina Gil-Cruz, Elke Scandella, Angelina De Martin, Urs Mörbe, Fabienne Hartmann, Robert Wenger, Matthias Spiegl, Andrej Besse, Weldy V. Bonilla, Felix Stemeseder, Sarah Schmidt, Klaus K. Orlinger, Philippe Krebs, Burkhard Ludewig, Lukas Flatz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cel
Externí odkaz:
https://doaj.org/article/6b57b0ebdd6c41a2b423f124d18a7987
Autor:
Henning Lauterbach, Sarah Schmidt, Kia Katchar, Xiaoping Qing, Corinne Iacobucci, Andy Hwang, Katia Schlienger, Ursula Berka, Josipa Raguz, Sarah Ahmadi-Erber, Timo Schippers, Felix Stemeseder, Daniel D. Pinschewer, Igor Matushansky, Klaus K. Orlinger
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Engineered viral vectors represent a promising strategy to trigger antigen-specific antitumor T cell responses. Arenaviruses have been widely studied because of their ability to elicit potent and protective T cell responses. Here, we provide an overv
Externí odkaz:
https://doaj.org/article/83895df6536743b1a3a0d3687cec5f20
Autor:
Sarah Schmidt, Weldy V. Bonilla, Andrea Reiter, Felix Stemeseder, Theresa Kleissner, Daniel Oeler, Ursula Berka, Ahmed El-Gazzar, Bettina Kiefmann, Sophie C. Schulha, Josipa Raguz, Mohamed Habbeddine, Marilies Scheinost, Xiaoping Qing, Henning Lauterbach, Igor Matushansky, Daniel D. Pinschewer, Klaus K. Orlinger
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Infection with human papillomavirus (HPV) is associated with a variety of cancer types and limited therapy options. Therapeutic cancer vaccines targeting the HPV16 oncoproteins E6 and E7 have recently been extensively explored as a promising immunoth
Externí odkaz:
https://doaj.org/article/8628c62f544f4bc38f1cf4d8148e2bab
Autor:
Judith Strauss, Diana Reckendorfer, Kimberly Pojar, Laura Codarri Deak, Valeria Nicolini, Roger Sutmuller, Christian Klein, Pablo Umaña, Klaus K. Orlinger, Henning Lauterbach
Publikováno v:
Cancer Research. 83:5747-5747
It is undisputed that CD8 T cells play a critical role in controlling tumor growth and killing tumor cells, and that tumor specific T cells are essential for clinical responses to immune checkpoint inhibitors. Yet, the induction and maintenance of fu
Autor:
Mette-Triin Purde, Fabienne Hartmann, Jovana Cupovic, Sarah Schmidt, David Bomze, Felix Stemeseder, Alexander Lercher, Lenka Besse, Fiamma Berner, Thomas Tüting, Andreas Bergthaler, Andrea Schietinger, Stefan Kochanek, Burkhard Ludewig, Klaus K. Orlinger, Tobias Bald, Sandra S. Ring, Lukas Flatz
Publikováno v:
Cancer Research. 82:3298-3298
Breaking self-tolerance and inducing a robust immune response targeting tumor cell derived self-antigens by therapeutic vaccines has remained challenging. We have generated a replicating viral vector based on the arenavirus lymphocytic choriomeningit
Autor:
Judith Strauss, Marilies Scheinost, Theresa Kleissner, Diana Reckendorfer, Kimberly Pojar, Mohamed Habbeddine, Sarah Ahmadi-Erber, Daniela Deutschmann, Sarah Schmidt, Josipa Raguz, Igor Matushansky, Christoph Lampert, Klaus K. Orlinger, Henning Lauterbach
Publikováno v:
Cancer Research. 82:4198-4198
T cells play a central role in immune responses against cancer. Within the tumor, however, T cells are exposed to a plethora of inactivating factors causing various degrees of dysfunction, changes in metabolism and a generally reduced cellular fitnes
Autor:
Josipa Raguz, Theresa Kleissner, Sandra Rosskopf, Mohamed Habbeddine, Katharina Lechner, Valentin Just, Donna Edwards, Igor Matushansky, Christoph Lampert, Klaus K. Orlinger, Henning Lauterbach
Publikováno v:
Cancer Research. 82:2048-2048
Cytotoxic CD8+ T cells are paramount for effective cancer immunotherapy. We engineered two distantly related arenaviruses, lymphocytic choriomeningitis virus (LCMV) and Pichinde virus (PICV), encoding the same non-oncogenic HPV16 E7E6 fusion protein
Autor:
Verena M. Hoenninger, Christian W. Mandl, Regina M. Kofler, Klaus K. Orlinger, Franz X. Heinz
Publikováno v:
Journal of Virology. 81:12619-12629
Flaviviruses have a positive-stranded RNA genome, which simultaneously serves as an mRNA for translation of the viral proteins. All of the structural and nonstructural proteins are translated from a cap-dependent cistron as a single polyprotein precu
Publikováno v:
Journal of Virology. 80:12197-12208
Flaviviruses have a monopartite positive-stranded RNA genome, which serves as the sole mRNA for protein translation. Cap-dependent translation produces a polyprotein precursor that is co- and posttranslationally processed by proteases to yield the fi