Zobrazeno 1 - 10
of 932
pro vyhledávání: '"Klaus Jung"'
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-15 (2024)
Abstract Background Spinal Muscular Atrophy (SMA), a neuromuscular disorder that leads to weakness in the muscles due to degeneration of motor neurons. Mutations in the survival motor neuron 1 (SMN1) gene leads to the deficiency of SMN protein that c
Externí odkaz:
https://doaj.org/article/0f8c8b1db5c24d9c837909283794abfc
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Unsupervised clustering and outlier detection are important in medical research to understand the distributional composition of a collective of patients. A number of clustering methods exist, also for high-dimensional data after d
Externí odkaz:
https://doaj.org/article/94744ab41ff743dea2b791fe63a3c123
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Introduction: Gene set enrichment analysis (GSEA) subsequent to differential expression analysis is a standard step in transcriptomics and proteomics data analysis. Although many tools for this step are available, the results are often difficult to r
Externí odkaz:
https://doaj.org/article/9d4264c0fbb949f9b85a5f40dff1d75b
Autor:
Praveen Papareddy, Michael Selle, Nicolas Partouche, Vincent Legros, Benjamin Rieu, Jon Olinder, Cecilia Ryden, Eva Bartakova, Michal Holub, Klaus Jung, Julien Pottecher, Heiko Herwald
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
ObjectiveThe purpose of this study was to identify a panel of biomarkers for distinguishing early stage sepsis patients from non-infected trauma patients.BackgroundAccurate differentiation between trauma-induced sterile inflammation and real infectiv
Externí odkaz:
https://doaj.org/article/8ace475a2c4648f8ba34ee2281017c06
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5286 (2024)
Clinical and preclinical studies have provided conflicting data on the postulated beneficial effects of vitamin D in patients with prostate cancer. In this opinion piece, we discuss reasons for discrepancies between preclinical and clinical vitamin D
Externí odkaz:
https://doaj.org/article/104631b3996f452c895820c4d4bd290e
Autor:
António A. R. Camarão, Olivia Luise Gern, Felix Stegmann, Felix Mulenge, Bibiana Costa, Babak Saremi, Klaus Jung, Bernd Lepenies, Ulrich Kalinke, Imke Steffen
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT The flavivirus non-structural protein 1 (NS1) is secreted from infected cells into the circulation and the serum levels correlate with disease severity. The effect of secreted NS1 (sNS1) on non-infected mammalian immune cells is largely unkn
Externí odkaz:
https://doaj.org/article/8b7b31e7272940889aff0ab0bf7b5f22
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Hair types have been under strong targeted selection in domestic animals for their impact on skin protection, thermoregulation and exterior morphology, and subsequent economic importance. In pigs, a very special hair phenotype was observed in Mangali
Externí odkaz:
https://doaj.org/article/92d0a408900747cbabb8c1ee987a4dce
Autor:
Babak Saremi, Frederic Gusmag, Ottmar Distl, Frank Schaarschmidt, Julia Metzger, Stefanie Becker, Klaus Jung
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Due to the overall high costs, technical replicates are usually omitted in RNA-seq experiments, but several methods exist to generate them artificially. Bootstrapping reads from FASTQ-files has recently been used in the context of other NGS
Externí odkaz:
https://doaj.org/article/4a321b675b6743508591f3e2f9a4856e
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Several studies have been performed to study transcriptome profiles after dengue virus infections with partly different results. Due to slightly different settings of the individual studies, different genes and enriched gene sets
Externí odkaz:
https://doaj.org/article/a22331932ea746688ddb441779322b5d
Autor:
Mareike Kubinski, Jana Beicht, Isabel Zdora, Giulietta Saletti, Magdalena Kircher, Monique Petry-Gusmag, Imke Steffen, Christina Puff, Klaus Jung, Wolfgang Baumgärtner, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus, Chittappen Kandiyil Prajeeth
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionNaturally attenuated Langat virus (LGTV) and highly pathogenic tick-borne encephalitis virus (TBEV) share antigenically similar viral proteins and are grouped together in the same flavivirus serocomplex. In the early 1970s, this has encou
Externí odkaz:
https://doaj.org/article/cd2d7e4a5c1945d09acddce03e75ca75