Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Klaus J Erb"'
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91223 (2014)
Severe asthma is characterised by persistent inflammation, hyperreactivity and remodeling of the airways. No efficient treatment is available, this is particularly the case for steroid resistant phenotypes. Our aim therefore was to develop a preclini
Externí odkaz:
https://doaj.org/article/fed1a984e9994db285540b225fae3408
Autor:
Jürgen Schymeinsky, Hannah Mayer, Christopher Tomsic, Cornelia Tilp, John D Schuetz, Yunhai Cui, Lutz Wollin, Florian Gantner, Klaus J Erb
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61193 (2013)
The multidrug resistance protein 4 (Mrp4) is an ATP-binding cassette transporter that is capable of exporting the second messenger cAMP from cells, a process that might regulate cAMP-mediated anti-inflammatory processes. However, using LPS- or cigare
Externí odkaz:
https://doaj.org/article/e2e06dc047eb4f51a34e631a7c869e56
Autor:
Bernd Weigle, Monica Menzenski, Pankaj Gupta, Sarah Low, Rachel Kroe-Barrett, Kavita Jerath, Sathyadevi Venkataramani, Klaus J. Erb, Rajkumar Ganesan, Darrin Dutcher, Sanjaya Singh, Kristopher Truncali, Lee Frego
Publikováno v:
Biochemical and Biophysical Research Communications. 504:19-24
Patients with severe Th2 type asthma often have a steroid resistant phenotype and are prone to acute exacerbations. Current novel therapies have only marginal therapeutic effects. One of the hypotheses for lack of major efficacy in most patients is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac9118b8fce286b145bbeac305fceb8
https://doi.org/10.1016/j.bbrc.2018.08.064
https://doi.org/10.1016/j.bbrc.2018.08.064
Autor:
Hannes Bucher, Birgit Jung, Michèl Przibilla, Samuel Mang, Martina Keck, Klaus Fuchs, David J. Lamb, Mareike Wittenbrink, Klaus J. Erb, Daniel Peter, Felix Schiele
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 44:96-105
Smoking is an important risk factor for the development of chronic obstructive pulmonary disease (COPD) and viral infections are believed to be major triggers of exacerbations, which periodically lead to a worsening of symptoms. The pro-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dad53d7cc86d147a4acc538fe14ce87
https://doi.org/10.1016/j.pupt.2017.03.008
https://doi.org/10.1016/j.pupt.2017.03.008
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Viral infections trigger exacerbations in chronic obstructive pulmonary disease (COPD), and tiotropium, a M3 receptor antagonist, reduces exacerbations in patients by unknown mechanisms. In this report, we investigated whether tiotropium has anti-inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fa2cafe145e0b4bb79258d94078f62
http://europepmc.org/articles/PMC4885512
http://europepmc.org/articles/PMC4885512
Publikováno v:
Clinical & Experimental Allergy. 46:957-972
Background Patients with asthma who smoke have reduced lung function, increased exacerbation rates and increased steroid resistance compared to non-smoking asthmatics. In mice, cigarette smoke has been reported to have both pro- and anti-Th2 response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a388a644abccf0e4e70d95c118152dbe
https://doi.org/10.1111/cea.12665
https://doi.org/10.1111/cea.12665
Autor:
Eric Borges, Monika Petersson, Valerie Laura Herrmann, John Edward Park, Philipp Mueller, Patrik Erlmann, Fabian Heinemann, Knut Elbers, Brigit Stierstorfer, Tobias Nolden, Maria Antonietta Impagnatiello, Guido Wollmann, Klaus J. Erb
Publikováno v:
Cancer Research. 80:4450-4450
Introduction Oncolytic viruses (OVs), which selectively replicate in and destroy tumor cells, represent a highly promising class of cancer therapeutics with a strong immune stimulatory potential. VSV-GP, a chimeric Vesicular Stomatitis Virus (VSV) ps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bd573947bbaea747ca6a113cb0f1429
https://doi.org/10.1158/1538-7445.am2020-4450
https://doi.org/10.1158/1538-7445.am2020-4450
Publikováno v:
Idiopathic interstitial pneumonias.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3662318d95d2f713b9751737001995b8
https://doi.org/10.1183/13993003.congress-2018.pa4797
https://doi.org/10.1183/13993003.congress-2018.pa4797
Autor:
Benjamin Strobel, Tobias Hildebrandt, Birgit Stierstorfer, Detlef Stiller, Ramona Schmid, Detlev Mennerich, Karsten Quast, Klaus J. Erb, Matthias J. Duechs, Florian Gantner, Sebastian Kreuz, Hannes Bucher
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:291-302
Viral vectors have been applied successfully to generate disease-related animal models and to functionally characterize target genes in vivo. However, broader application is still limited by complex vector production, biosafety requirements, and vect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3def45fbb073d7cdaca39008b3f29a
https://doi.org/10.1165/rcmb.2014-0338ma
https://doi.org/10.1165/rcmb.2014-0338ma
Publikováno v:
International archives of allergy and immunology. 173(2)
The past 20 years have seen a proliferation of scientific data on the pathophysiology of asthma. Most of these data were generated in mice using tool reagents, gene-deficient or transgenic animals. In contrast, studies on disease pathogenesis in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9e7369276def41a3ecb57c8704110b
https://pubmed.ncbi.nlm.nih.gov/28586774
https://pubmed.ncbi.nlm.nih.gov/28586774