Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Klaus Holzmann"'
Autor:
Alexander Ries, Astrid Slany, Christine Pirker, Johanna C. Mader, Doris Mejri, Thomas Mohr, Karin Schelch, Daniela Flehberger, Nadine Maach, Muhammad Hashim, Mir Alireza Hoda, Balazs Dome, Georg Krupitza, Walter Berger, Christopher Gerner, Klaus Holzmann, Michael Grusch
Publikováno v:
Cells, Vol 12, Iss 15, p 2006 (2023)
Pleural mesothelioma (PM) is an aggressive malignancy that develops in a unique tumor microenvironment (TME). However, cell models for studying the TME in PM are still limited. Here, we have generated and characterized novel human telomerase reverse
Externí odkaz:
https://doaj.org/article/8865651d49ae4f9aa0376956496bb9c2
Autor:
Franziska Ferk, Miroslav Mišík, Benjamin Ernst, Gerhard Prager, Christoph Bichler, Doris Mejri, Christopher Gerner, Andrea Bileck, Michael Kundi, Sabine Langie, Klaus Holzmann, Siegfried Knasmueller
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 760 (2023)
Obesity causes genetic instability, which plays a key-role in the etiology of cancer and aging. We investigated the impact of bariatric surgery (BS) on DNA repair, oxidative DNA damage, telomere lengths, alterations of antioxidant enzymes and, select
Externí odkaz:
https://doaj.org/article/5729480f1ba64fabba0553fff2006828
Autor:
Thomas Aschacher, Brigitte Wolf, Olivia Aschacher, Florian Enzmann, Viktoria Laszlo, Barbara Messner, Adrian Türkcan, Serge Weis, Sabine Spiegl-Kreinecker, Klaus Holzmann, Günther Laufer, Marek Ehrlich, Michael Bergmann
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 61-75 (2020)
Malignant cells ensure telomere maintenance by the alternative lengthening of telomeres (ALT) in the absence of telomerase activity (TA). The retrotransposons “long interspersed nuclear element-1” (LINE-1, L1) are expressed in malignant cells and
Externí odkaz:
https://doaj.org/article/59b8f979431749d7b9261af0ff72292d
Autor:
Zeynep N. Erdem, Stefanie Schwarz, Daniel Drev, Christine Heinzle, Andrea Reti, Petra Heffeter, Xenia Hudec, Klaus Holzmann, Bettina Grasl-Kraupp, Walter Berger, Michael Grusch, Brigitte Marian
Publikováno v:
Translational Oncology, Vol 10, Iss 3, Pp 332-339 (2017)
BACKGROUND: Irinotecan (IRI) is an integral part of colorectal cancer (CRC) therapy, but response rates are unsatisfactory and resistance mechanisms are still insufficiently understood. As fibroblast growth factor receptor 3 (FGFR3) mediates essentia
Externí odkaz:
https://doaj.org/article/ad7b73d6acc34f24a8adc7e89f31908a
Autor:
Klaus Holzmann, Brigitte Marian
Publikováno v:
Cells, Vol 8, Iss 10, p 1191 (2019)
Fibroblast growth factors (FGFs) are a large family of protein ligands that exert a wide range of biological effects in many organs/tissues by activating receptors (FGFRs) of the tyrosine kinase superfamily [...]
Externí odkaz:
https://doaj.org/article/f538069d8d414b498ece8bf0691d9d8f
Autor:
Thomas Aschacher, Sandra Sampl, Lisa Käser, David Bernhard, Andreas Spittler, Klaus Holzmann, Michael Bergmann
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 1, Pp 44-53 (2012)
A hallmark of tumor cell survival is the maintenance of elongated telomeres. It is known that antiviral reverse transcriptase inhibitors (RTIs) such as azidothymidine (AZT) and didanosine (ddI) lead to telomere shortening at high, potentially toxic c
Externí odkaz:
https://doaj.org/article/fa3c43b81c2a4643be32d1685d020a85
Autor:
Klaus Holzmann, Thomas Grunt, Christine Heinzle, Sandra Sampl, Heinrich Steinhoff, Nicole Reichmann, Miriam Kleiter, Marlene Hauck, Brigitte Marian
Publikováno v:
Journal of Nucleic Acids, Vol 2012 (2012)
Alternative splicing of the IgIII loop of fibroblast growth factor receptors (FGFRs) 1–3 produces b- and c-variants of the receptors with distinctly different biological impact based on their distinct ligand-binding spectrum. Tissue-specific expres
Externí odkaz:
https://doaj.org/article/5005970e88834c6eae5fda54a48580c2
Autor:
Walter Berger, Michael Micksche, Brigitte Marian, Christine Gauglhofer, Bettina Grasl-Kraupp, Heidelinde Cantonati, Leonilla Elbling, Ulrike Setinek, Klaus Holzmann, Gudrun Sonvilla, Michael Grusch, Sigrid Allerstorfer, Ninon Taylor, Hendrik Fischer
Supplementary Fig. S1 from Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1dd383dbbf6c52ee6723105fea1fd5
https://doi.org/10.1158/1535-7163.22482914
https://doi.org/10.1158/1535-7163.22482914
Autor:
Walter Berger, Michael Micksche, Brigitte Marian, Christine Gauglhofer, Bettina Grasl-Kraupp, Heidelinde Cantonati, Leonilla Elbling, Ulrike Setinek, Klaus Holzmann, Gudrun Sonvilla, Michael Grusch, Sigrid Allerstorfer, Ninon Taylor, Hendrik Fischer
Supplementary Table S2 from Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81271effce5caa4e381d6d2ec21046e9
https://doi.org/10.1158/1535-7163.22482908.v1
https://doi.org/10.1158/1535-7163.22482908.v1
Autor:
Walter Berger, Michael Micksche, Brigitte Marian, Christine Gauglhofer, Bettina Grasl-Kraupp, Heidelinde Cantonati, Leonilla Elbling, Ulrike Setinek, Klaus Holzmann, Gudrun Sonvilla, Michael Grusch, Sigrid Allerstorfer, Ninon Taylor, Hendrik Fischer
Fibroblast growth factors (FGF) and their high-affinity receptors (FGFR) represent an extensive cellular growth and survival system. Aim of this study was to evaluate the contribution of FGF/FGFR-mediated signals to the malignant growth of non-small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3752529f2ce8cfe5267245b5641eea7
https://doi.org/10.1158/1535-7163.c.6531038
https://doi.org/10.1158/1535-7163.c.6531038