Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Klaus Hinterding"'
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Synthesis of Chiral Analoguesof FTY720 and its Phosphate
Autor: Klemens Hoegenauer, Sylvain Cottens, Peter Nussbaumer, Frédéric Zecri, Peter Buehlmayer, Nathanael S. Gray, Shifeng Pan, Rainer Albert, Klaus Hinterding, Carsten Spanka, Peter Ettmayer, Volker Brinkmann
Publikováno v: Synthesis. 2003:1667-1670
Efficient and versatile protocols for the synthesis of chiral analogues of the novel immunomodulator FTY720 and its phosphate are described. These synthetic procedures allow for broad structural variation and deliver essential tools to further elucid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6ea5217d1245081996932ac4d345f6e
https://doi.org/10.1055/s-2003-40883
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4
Synthesis and In Vitro Evaluation of the Farnesyltransferase Inhibitor Pepticinnamin E
Autor: János Rétey, Herbert Waldmann, Klaus Hinterding, Patrizia Hagenbuch
Publikováno v: Chemistry - A European Journal. 5:227-236
A modularly built bisubstrate inhibitor of farnesyltransferase, pepticinnamin E (depicted), has been synthesized and its inhibitory activity studied. The latter is decisively influenced by the central tripeptide unit and the absolute configuration of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62768e1fe555b48f9d48f2bedbca93ab
https://doi.org/10.1002/(sici)1521-3765(19990104)5:1<227::aid-chem227>3.0.co
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5
Synthesis and In Vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E
Autor: János Rétey, Klaus Hinterding, Herbert Waldmann, Patrizia Hagenbuch
Publikováno v: Angewandte Chemie International Edition. 37:1236-1239
A modularly built bisubstrate inhibitor, the natural product pepticinnamin E (shown on the right) was sythesized for the first time. In the case of in vitro assays it inhibits the enzyme farnesyltransferase with respect to both the peptide substrate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4126f1d15c243057623bb5734572ff
https://doi.org/10.1002/(sici)1521-3773(19980518)37:9<1236::aid-anie1236>3.0.co
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6
Synthese und In-vitro-Evaluierung des Ras-Farnesyltransferase-Inhibitors Pepticinnamin E
Autor: Patrizia Hagenbuch, Klaus Hinterding, Herbert Waldmann, János Rétey
Publikováno v: Angewandte Chemie. 110:1298-1301
Ein modular aufgebauter Bisubstratinhibitor ist die naturlich vorkommende Titelverbindung (rechts gezeigt), die nun erstmals synthetisiert wurde. Bei In-vitro-Assays hemmte sie das Enzym Farnesyltransferase sowohl bezuglich eines Peptidsubtrats als a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93c68d4470885480f7c501d77a9eeb64
https://doi.org/10.1002/(sici)1521-3757(19980504)110:9<1298::aid-ange1298>3.0.co
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7
Organic Synthesis and Biological Signal Transduction
Autor: Herbert Waldmann, Klaus Hinterding, Daniel Alonso-Díaz
Publikováno v: Angewandte Chemie International Edition. 37:688-749
The understanding of cellular communication pathways in molecular detail is an important goal of bioorganic research. The synthesis of analogues of active substances (e.g. 1) to study the regulation of muscle contraction or the specific lipid modific
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bae43f5099490d5008db2c8eb551ef
https://doi.org/10.1002/(sici)1521-3773(19980403)37:6<688::aid-anie688>3.0.co
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8
Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator
Autor: Anne Gardin, Nathanael S. Gray, Barbara Nuesslein-Hildesheim, Klaus Hinterding, Jianwei Che, Yi Fan, Xing Wang, Yuan Mi, Tove Tuntland, Wenqi Gao, Shifeng Pan, Yu Chen, Peter End, Christian Bruns, Nigel Graham Cooke, Peter Heining, Alan Chu, Sophie Lefebvre
Publikováno v: ACS medicinal chemistry letters. 4(3)
A novel series of alkoxyimino derivatives as S1P1 agonists were discovered through de novo design using FTY720 as the chemical starting point. Extensive structure–activity relationship studies led to the discovery of (E)-1-(4-(1-(((4-cyclohexyl-3-(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a100c42b0d5094958ff302d921cba6c3
https://pubmed.ncbi.nlm.nih.gov/24900670
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9
First asymmetric synthesis of chiral analogues of the novel immunosuppressant FTY720
Autor: Sylvain Cottens, Rainer Albert, Klaus Hinterding
Publikováno v: Tetrahedron Letters. 43:8095-8097
FTY720 is an immunosuppressant with a novel mode of action and is highly effective in animal models of transplantation and autoimmunity. Herein we describe the first asymmetric synthesis of chiral FTY720 analogues using the Schollkopf-protocol. We al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6af3ec076268e2b29722916fffe5f71f
https://doi.org/10.1016/s0040-4039(02)01925-1
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10
Stereoselective synthesis of polyketide fragments using a novel intramolecular Claisen-like condensation/reduction sequence
Autor: Suradech Singhanat, Klaus Hinterding, Lukas Oberer
Publikováno v: Tetrahedron Letters. 42:8463-8465
Intramolecular Claisen-type cleavage of the Evans-oxazolidinone with an acetate enolate followed by reduction of the resulting ketone using a borane–amine complex yielded β-hydroxy-δ-lactones as fully functionalized polyketide precursors stereose
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6db29765b9f5e03275519a47ae9e37f
https://doi.org/10.1016/s0040-4039(01)01840-8
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