Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Klaus Hexel"'
Autor:
Maria Xydia, Raheleh Rahbari, Eliana Ruggiero, Iain Macaulay, Maxime Tarabichi, Robert Lohmayer, Stefan Wilkening, Tillmann Michels, Daniel Brown, Sebastiaan Vanuytven, Svetlana Mastitskaya, Sean Laidlaw, Niels Grabe, Maria Pritsch, Raffaele Fronza, Klaus Hexel, Steffen Schmitt, Michael Müller-Steinhardt, Niels Halama, Christoph Domschke, Manfred Schmidt, Christof von Kalle, Florian Schütz, Thierry Voet, Philipp Beckhove
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their
Externí odkaz:
https://doaj.org/article/564548dac492461fa165fbbe611c1237
Autor:
Stefan Wilkening, Christof von Kalle, Svetlana Mastitskaya, Klaus Hexel, Daniel Brown, Iain C. Macaulay, Raheleh Rahbari, Steffen Schmitt, Philipp Beckhove, Christoph Domschke, Robert Lohmayer, Michael Müller-Steinhardt, Niels Grabe, Sebastiaan Vanuytven, Tillmann Michels, Niels Halama, Raffaele Fronza, Thierry Voet, Sean Laidlaw, Manfred G. Schmidt, Maria Pritsch, Maxime Tarabichi, Maria Xydia, Eliana Ruggiero, Florian Schütz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Regulatory CD4+ T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers remain largely unclear. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0423cce2352b457db876fe4c5bf581
https://lirias.kuleuven.be/handle/20.500.12942/687034
https://lirias.kuleuven.be/handle/20.500.12942/687034
Autor:
Charlotte Bunne, Mona Tomaschko, Lisa Buchauer, Muhammad Amir Khan, Anna Neuerburg, Chunxuan Shao, Heike Alter, Klaus Hexel, Azer Aylin Acikgöz, Peng Zou, Hai-Kun Liu, Katharina Hartmann, Zhe Zhu, Weijun Feng, Thomas Höfer, Yue Zhuo, Gözde Bekki, Mengran Qian, Olga Friesen
How overall tumor growth emerges from the properties of functionally heterogeneous tumor cell subpopulations is a fundamental question of cancer biology. Here we combined lineage tracing, continuous monitoring of tumor mass, proliferation assays and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe6a5cc1618de80ab67a533b5d99f5c
https://doi.org/10.1101/723601
https://doi.org/10.1101/723601
Publikováno v:
Proceedings of the National Academy of Sciences. 105:657-662
Promiscuous expression of tissue-restricted autoantigens in medullary thymic epithelial cells (mTECs) imposes central T cell tolerance. The molecular regulation of this unusual gene expression is not understood, in particular its delineation from cel
Autor:
Simon Haas, Alexandra Schnell, Jeroen Krijgsveld, Timm Schroeder, Áine M. Prendergast, Klaus Hexel, Michael D. Milsom, Stephan Wurzer, Marieke A.G. Essers, Rachel Santarella-Mellwig, Andrea Kuck, Hannah Uckelmann, Andreas Trumpp, Sandra Blaszkiewicz, Hartmut Geiger, Lars M. Steinmetz, Jenny Hansson, Dirk Loeffler, Daniel Klimmeck, Lars Velten
Publikováno v:
Cell stem cell. 17(4)
SummaryInfections are associated with extensive platelet consumption, representing a high risk for health. However, the mechanism coordinating the rapid regeneration of the platelet pool during such stress conditions remains unclear. Here, we report
Autor:
Stephanie Kadel, Klaus Hexel, Birgit Brenner, Minh-Chau Phong, Paul Gutwein, Peter Altevogt, Otwin Linderkamp
Publikováno v:
Biochemical and Biophysical Research Communications. 300:563-569
Leukocyte recruitment to lymph nodes or inflammatory sites is regulated by adhesion and activation. L-selectin (CD62L) is expressed on leukocytes and mediates tethering and rolling of leukocytes on endothelial cells. Uponstimulation L-selectin is dow
Stem Cell-like Megakaryocyte Progenitors As Driving Forces of IFN-Induced Emergency Megakaryopooesis
Autor:
Áine M. Prendergast, Jeroen Krijgsveld, Simon Haas, Klaus Hexel, Marieke A.G. Essers, Michael D. Milsom, Rachel Santarella-Mellwig, Hannah Uckelmann, Alexandra Schnell, Dirk Loeffler, Daniel Klimmeck, Hartmut Geiger, Sandra Blaszkiewicz, Lars Velten, Lars M. Steinmetz, Jenny Hansson, Andrea Kuck, Andreas Trumpp, Stephan Wurzer, Timm Schroeder
Publikováno v:
Blood. 126:2391-2391
Recent reports have highlighted the importance of platelets as inflammatory and immune cells in addition to their well-known function in thrombosis. Systemic inflammation associated with acute infection triggers the release of immune-modulatory agent
Autor:
Minh-Chau, Phong, Paul, Gutwein, Stephanie, Kadel, Klaus, Hexel, Peter, Altevogt, Otwin, Linderkamp, Birgit, Brenner
Publikováno v:
Biochemical and biophysical research communications. 300(2)
Leukocyte recruitment to lymph nodes or inflammatory sites is regulated by adhesion and activation. L-selectin (CD62L) is expressed on leukocytes and mediates tethering and rolling of leukocytes on endothelial cells. Upon stimulation L-selectin is do
Autor:
Stephanie Kadel, Paul Gutwein, Birgit Brenner, Peter Altevogt, Klaus Hexel, Minh-Chau Phong, Otwin Linderkamp
Publikováno v:
Biochemical and Biophysical Research Communications. 302:916