Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Klaus Harbers"'
Publikováno v:
European Journal of Biochemistry. 268:5912-5919
Recent results from several laboratories suggest that the interaction of E2 ubiquitin-conjugating enzymes with the RING finger domain has a central role in mediating the transfer of ubiquitin to proteins. Here we present a mutational analysis of the
Publikováno v:
Journal of Biological Chemistry. 276:19617-19623
The U-box domain has been suggested to be a modified RING finger motif where the metal-coordinating cysteines and histidines have been replaced with other amino acids. Known U-box-containing proteins have been implicated in the ubiquitin/proteasome s
Publikováno v:
FEBS Letters. 454:257-261
The ubiquitin-conjugating enzyme UbcM4 was previously shown to be necessary for normal mouse development. As a first step in identifying target proteins or proteins involved in the specificity of UbcM4-mediated ubiquitylation, we have isolated seven
Autor:
Ursula Müller, Klaus Harbers, Debra J. Gilbert, Nancy A. Jenkins, Neal G. Copeland, Anja Grams, Gustavo Martinez-Noel
Publikováno v:
Gene. 224:109-116
Ubiquitin-conjugating enzymes (E2 or Ubc) play a key role in the post-translational modification of proteins by ubiquitylation. They are encoded by a large family of genes that are closely related to each other. In this paper we present the first com
Autor:
Payman Salimi-Tari, Isabel Tran, John T. Tracy, Klaus Harbers, Michèlle Cheung, Michael Breindl, Caroline A. Safar
Publikováno v:
Gene. 198:61-72
We have isolated molecular clones of genomic mouse DNA spanning 55 kb, including the entire coding region of the murine α 1(I) collagen ( Col1a1 ) gene and 24 kb of 5′ and 13 kb of 3′-flanking sequences, and have performed a detailed chromatin s
Publikováno v:
Proceedings of the National Academy of Sciences. 93:12412-12417
Ubiquitin-conjugating enzymes (E2 or Ubc) constitute a family of conserved proteins that play a key role in ubiquitin-dependent degradation of proteins in eukaryotes. We describe here a transgenic mouse strain where retrovirus integration into an Ubc
Publikováno v:
Developmental Dynamics. 198:273-283
Cell type-specific differences in the transcriptional control of the mouse gene coding for theα1 chain of collagen type I (Col1a1) have been revealed previously with the help of the Mov13 mouse strain which carries a retroviral insert in the first i
Publikováno v:
Molecular and Cellular Biology. 12:3644-3652
The transgenic mouse strain CAT40 carries in its germ line one copy of a DNA construct consisting of the chloramphenicol acetyltransferase gene and the immunoglobulin heavy-chain enhancer. We show that transgene integration has resulted in a recessiv
Publikováno v:
Molecular and Cellular Biology. 11:886-893
The Mov-10 mouse strain was derived by infection of preimplantation embryos with the Moloney murine leukemia virus and carries one copy of the provirus in its germ line. Here we show that the provirus has integrated into an evolutionarily conserved g
Publikováno v:
Cytogenetic and Genome Research. 53:129-133
The pseudoautosomal region of the Mov15 mouse strain is marked by a Moloney murine leukemia provirus. The sequences flanking the Mov15 provirus were molecularly cloned and shown to consist of a tandemly repeated sequence of 31 nucleotides. Copy numbe