Zobrazeno 1 - 10
of 732
pro vyhledávání: '"Klaus F. Rabe"'
Autor:
Birte Ehrhardt, Hanna Angstmann, Beate Höschler, Draginja Kovacevic, Barbara Hammer, Thomas Roeder, Klaus F. Rabe, Christina Wagner, Karin Uliczka, Susanne Krauss-Etschmann
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Serine proteases are important regulators of airway epithelial homeostasis. Altered serum or cellular levels of two serpins, Scca1 and Spink5, have been described for airway diseases but their function beyond antiproteolytic activity is insu
Externí odkaz:
https://doaj.org/article/6db17430acc04ff2b78194f3ababa535
Autor:
Franziska C. Trudzinski, Rudolf A. Jörres, Peter Alter, Henrik Watz, Claus F. Vogelmeier, Hans-Ulrich Kauczor, Subasini Thangamani, Manuel Debic, Tobias Welte, Jürgen Behr, Kathrin Kahnert, Robert Bals, Christian Herr, Claus Peter Heußel, Jürgen Biederer, Oyunbileg von Stackelberg, Sebastian Fähndrich, Emiel F. M. Wouters, Benjamin Waschki, Klaus F. Rabe, Felix J. F. Herth, Viktoria Palm, COSYCONET study group
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Patients with COPD are often affected by loss of bone mineral density (BMD) and osteoporotic fractures. Natriuretic peptides (NP) are known as cardiac markers, but have also been linked to fragility-associated fractures in the eld
Externí odkaz:
https://doaj.org/article/adadd9ca5c334e58ae95cbe9771279f4
Autor:
Jennifer A. Zader, Rudolf A. Jörres, Imke Mayer, Peter Alter, Robert Bals, Henrik Watz, Pontus Mertsch, Klaus F. Rabe, Felix Herth, Franziska C. Trudzinski, Tobias Welte, Hans-Ulrich Kauczor, Jürgen Behr, Julia Walter, Claus F. Vogelmeier, Kathrin Kahnert
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Randomized controlled trials described beneficial effects of inhaled triple therapy (LABA/LAMA/ICS) in patients with chronic obstructive pulmonary disease (COPD) and high risk of exacerbations. We studied whether such effects were
Externí odkaz:
https://doaj.org/article/27c46972185c4c5da5640308713951a3
Autor:
Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen, Chris Brightling, Alberto Papi, Klaus F. Rabe, Salman Siddiqui, Dave Singh, Monica Kraft, Bianca Beghe, Maarten van den Berge, Djoke van Gosliga, Martijn C. Nawijn, Stefan Rose-John, Gerard H. Koppelman, Reinoud Gosens
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that target type 2-low inflammation. Previous studies have linked IL-6 signaling to severe asthma.
Externí odkaz:
https://doaj.org/article/e4d93162eadc447d86daca4b0d26e0df
Autor:
Hanna Angstmann, Stefan Pfeiffer, Susanne Kublik, Birte Ehrhardt, Karin Uliczka, Klaus F. Rabe, Thomas Roeder, Christina Wagner, Michael Schloter, Susanne Krauss-Etschmann
Publikováno v:
Environmental Microbiome, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract Background The fruit fly Drosophila melanogaster lives in natural habitats and has also long been used as a model organism in biological research. In this study, we used a molecular barcoding approach to analyse the airways microbiome of lar
Externí odkaz:
https://doaj.org/article/61c139facffd402c812eb4039226087d
Autor:
Christian Domingo, Klaus F. Rabe, David Price, Guy Brusselle, Michael E. Wechsler, Changming Xia, Nami Pandit-Abid, Rebecca Gall, Paul J. Rowe, Yamo Deniz, Juby A. Jacob-Nara, Amr Radwan
Publikováno v:
ERJ Open Research, Vol 9, Iss 6 (2023)
Background Dupilumab has been shown to improve clinical outcomes long term while reducing oral corticosteroid (OCS) dose in patients with severe OCS-dependent asthma. This post hoc analysis assesses the impact of OCS dose at baseline (≤10 or >10 mg
Externí odkaz:
https://doaj.org/article/4cc17fdbebce48e9b57861c1623c47cb
Autor:
Peter Alter, Kathrin Kahnert, Franziska C. Trudzinski, Robert Bals, Henrik Watz, Tim Speicher, Sandra Söhler, Tobias Welte, Klaus F. Rabe, Emiel F. M. Wouters, Claus F. Vogelmeier, Rudolf A. Jörres
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 17 (2023)
Background: The use of maintenance medication in patients with chronic obstructive pulmonary disease (COPD) in real life is known to deviate from recommendations in guidelines, which are largely based on randomized controlled trials and selected popu
Externí odkaz:
https://doaj.org/article/f589adc1f8664e54a841cb3fb776bfd2
Autor:
Peter Alter, Tanja Lucke, Henrik Watz, Stefan Andreas, Kathrin Kahnert, Franziska C. Trudzinski, Tim Speicher, Sandra Söhler, Robert Bals, Benjamin Waschki, Tobias Welte, Klaus F. Rabe, Jørgen Vestbo, Emiel F. M. Wouters, Claus F. Vogelmeier, Rudolf A. Jörres
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract In chronic obstructive pulmonary disease (COPD), comorbidities and worse functional status predict worse outcomes, but how these predictors compare with regard to different outcomes is not well studied. We thus compared the role of cardiovas
Externí odkaz:
https://doaj.org/article/e8d7bdc438684dbcac6ae4e2a7f1be38
Autor:
Lucia De Prado Gomez, Ian Pavord, William Busse, Christopher E. Brightling, Michael E. Wechsler, Klaus F. Rabe, Mei Zhang, Jun Xing, Juby A. Jacob-Nara, Paul J. Rowe
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background Many patients with asthma experience loss of lung function over time, and in certain patients this can lead to progressive obstructive patterns similar to COPD. Patients with severe asthma may experience accelerated lung function decline (
Externí odkaz:
https://doaj.org/article/29665b18d99e4e989031208479d20f81
Autor:
Timothy Rajakumar, Rastislav Horos, Julia Jehn, Judith Schenz, Thomas Muley, Oana Pelea, Sarah Hofmann, Paul Kittner, Mustafa Kahraman, Marco Heuvelman, Tobias Sikosek, Jennifer Feufel, Jasmin Skottke, Dennis Nötzel, Franziska Hinkfoth, Kaja Tikk, Alberto Daniel-Moreno, Jessika Ceiler, Nathaniel Mercaldo, Florian Uhle, Sandra Uhle, Markus A. Weigand, Mariam Elshiaty, Fabienne Lusky, Hannah Schindler, Quentin Ferry, Tatjana Sauka-Spengler, Qianxin Wu, Klaus F. Rabe, Martin Reck, Michael Thomas, Petros Christopoulos, Bruno R. Steinkraus
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-13 (2022)
Abstract Immunotherapies have recently gained traction as highly effective therapies in a subset of late-stage cancers. Unfortunately, only a minority of patients experience the remarkable benefits of immunotherapies, whilst others fail to respond or
Externí odkaz:
https://doaj.org/article/db0758eed23b499e84eeb809e4369d62