Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Klaus Ersfeld"'
Publikováno v:
Microorganisms, Vol 9, Iss 11, p 2234 (2021)
Trypanosome brucei, the causative agent of African sleeping sickness, harbours a highly ordered, subpellicular microtubule cytoskeleton that defines many aspects of morphology, motility and virulence. This array of microtubules is associated with a l
Externí odkaz:
https://doaj.org/article/9cf8f642db6742d796672ed76d8725e8
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001050 (2010)
Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are now tested in clinical studies.
Externí odkaz:
https://doaj.org/article/c273ee251001455cb01c964d07ba1bf1
Autor:
Tariq A. Khan, Ibrahim S. Al Nasr, Waleed S. Koko, Jingyi Ma, Simon Eckert, Lucas Brehm, Ridha Ben Said, Ismail Daoud, Riadh Hanachi, Seyfeddine Rahali, Wendy W. J. van de Sande, Klaus Ersfeld, Rainer Schobert, Bernhard Biersack
Publikováno v:
ChemMedChem. John Wiley & Sons Ltd.
A series of synthetic N-acylpyrrolidone and -piperidone derivatives of the natural alkaloid piperlongumine were prepared and tested for their activities against Leishmania major and Toxoplasma gondii parasites. Replacement of one of the aryl meta-met
Autor:
Doranda Perdomo, Elodie Berdance, Gertrud Lallinger-Kube, Annelise Sahin, Denis Dacheux, Nicolas Landrein, Anne Cayrel, Klaus Ersfeld, Mélanie Bonhivers, Linda Kohl, Derrick R. Robinson
Publikováno v:
Parasite (Paris, France). 29
The flagellar pocket (FP) of the pathogen Trypanosoma brucei is an important single copy structure that is formed by the invagination of the pellicular membrane. It is the unique site of endo- and exocytosis and is required for parasite pathogenicity
Autor:
Amin Shaikh, Rainer Schobert, Jana Jentzsch, Bernhard Biersack, Priti Singh Shuveksh, Ibrahim Al Nasr, Tariq A. Khan, Waleed S. Koko, Khursheed Ahmed, Klaus Ersfeld
Publikováno v:
Chemistrybiodiversity. 18(1)
New pyranonaphthoquinone derivatives were synthesized and investigated for their activity against Trypanosoma brucei, Leishmania major, and Toxoplasma gondii parasites. The pentafluorophenyl derivative was efficacious against T. brucei with single di
Autor:
Jana, Jentzsch, Adal, Sabri, Konstantin, Speckner, Gertrud, Lallinger-Kube, Matthias, Weiss, Klaus, Ersfeld
Publikováno v:
Journal of cell science. 133(18)
The shape of kinetoplastids, such as
Autor:
Waleed S. Koko, Ibrahim Al Nasr, Bernhard Biersack, Klaus Ersfeld, Jana Jentzsch, Rainer Schobert, Tariq A. Khan
Publikováno v:
Chemistry & Biodiversity. 17
A series of bis-naphthoquinone derivatives prepared by condensation of aryl aldehydes with lawsone were tested for antiparasitic activities against Toxoplasma gondii and Trypanosoma brucei parasites. Monofluorophenyl derivative 1a, 3,4-difluorophenyl
Autor:
Matthias Weiss, Gertrud Lallinger-Kube, Konstantin Speckner, Jana Jentzsch, Klaus Ersfeld, Adal Sabri
Publikováno v:
Journal of Cell Science.
The shape of kinetoplastids, such as Trypanosoma brucei, is precisely defined during the stages of the life cycle and governed by a stable subpellicular microtubule cytoskeleton. During the cell cycle and transitions between life cycle stages this st
Autor:
Tariq A. Khan, Klaus Ersfeld, Ibrahim Al Nasr, Rainer Schobert, Jana Jentzsch, Waleed S. Koko, Bernhard Biersack, Hussein Kalie
Publikováno v:
Archiv der PharmazieREFERENCES. 353(5)
A series of cationic gold(I)-carbene complexes with various 4,5-diarylimidazolylidene ligands were either newly prepared or repurposed for testing against protozoal Leishmania major, Toxoplasma gondii, and Trypanosoma brucei parasites. The syntheses
Autor:
Julia Lockhauserbäumer, Rainer Schobert, Bernhard Biersack, Klaus Ersfeld, Gertrud Lallinger-Kube, Isabel Winter
Publikováno v:
Molecular and Biochemical Parasitology. 214:112-120
Two gold(I) N-heterocyclic carbene complexes 1a and 1b were tested for their anti-trypanosomal activity against Trypanosoma brucei parasites. Both gold compounds exhibited excellent anti-trypanosomal activity (IC50=0.9-3.0nM). The effects of the gold