Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Klaus D. Beck"'
Publikováno v:
Journal of Neurochemistry. 69:986-994
The c-ret protooncogene encodes Ret, the functional tyrosine kinase receptor for glial cell line-derived neurotrophic factor (GDNF). K-252b, a known protein tyrosine kinase inhibitor, has been shown earlier to inhibit the trophic activity of brain-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9eaaf0b4638ccb79162ae121105d9f
https://doi.org/10.1046/j.1471-4159.1997.69030986.x
https://doi.org/10.1046/j.1471-4159.1997.69030986.x
Autor:
Shuying Liu, Klaus D. Beck, Yanbin Yu, Ren Y. Xu, Kevin Pong, James J. S. Treanor, Jean-Claude Louis, Jack Lile, David Chang
Publikováno v:
Journal of Neurochemistry. 70:1383-1393
Here we report the generation and characterization of two distinct monoclonal antibodies, G-90 and B-1531, specific to glial cell line-derived neurotrophic factor (GDNF). ELISA results confirmed that G-90 and B-1531 both recognize GDNF. Western blots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5cde1926ca05dacf8d8b1f87f39893
https://doi.org/10.1046/j.1471-4159.1998.70041383.x
https://doi.org/10.1046/j.1471-4159.1998.70041383.x
Autor:
Natasha Shinsky, Lyn Powell-Braxton, Kathleen A. Elias, Wei-Qiang Gao, Gladys Ingle, Klaus D. Beck
Publikováno v:
Journal of Neurobiology. 39:142-152
Although insulin-like growth factor-I (IGF-I) can act as a neurotrophic factor for peripheral neurons in vitro and in vivo following injury, the role IGF-I plays during normal development and functioning of the peripheral nervous system is unclear. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::967f2221357c00358d7e5f027a740d6d
https://doi.org/10.1002/(sici)1097-4695(199904)39:1<142::aid-neu11>3.0.co
https://doi.org/10.1002/(sici)1097-4695(199904)39:1<142::aid-neu11>3.0.co
Publikováno v:
Neuron. 16(3):665-673
To test whether glial cell line–derived neurotrophic factor (GDNF) regulates the development of nigral dopaminergic neurons in vivo, neonatal rats received bilateral injections of GDNF into the striatum. Injections at postnatal day 2 induced a uniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d108661fcd47c90eea5addc20fe2bf72
Autor:
Janet Valverde, Klaus D. Beck, Suzy C. Wong, Ingrid W. Caras, Franz Hefti, Siao Ping Tsai, Jean O Yuan, John W. Winslow, Audrey Goddard, Paul Moran, William J. Henzel, A. Shih
Publikováno v:
Neuron. 14(5):973-981
REK7 is an Eph-related tyrosine kinase receptor expressed exclusively in the nervous system, predominantly in hippocampus and cortex. A soluble REK7-IgG fusion protein, produced to analyze the biological role of REK7, prevents axon bundling in cocult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a252aef39622ea1b4c386b8164fac93
Publikováno v:
Neuron. 14:717-730
Homozygous Igf1−1− mice at 2 months of age had reduced brain weights, with reductions evenly affecting all major brain areas. The gross morphology of the CNS was normal, but the size of white matter structures in brain and spinal cord was strongl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149fa8184a6bf11d134bc9e500c21289
https://doi.org/10.1016/0896-6273(95)90216-3
https://doi.org/10.1016/0896-6273(95)90216-3
Publikováno v:
Neuroscience. 61:257-268
Excitotoxic striatal lesions induced by quinolinic acid, a model for Huntington's disease, were used to test for neuroprotective actions of nerve growth factor on striatal cholinergic and GABAergic neurons. Expressions of the trk A receptor for nerve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c5e36f9474d2cd8f3e31096c350ca0
https://doi.org/10.1016/0306-4522(94)90229-1
https://doi.org/10.1016/0306-4522(94)90229-1
Publikováno v:
Neuroscience. 59:797-815
The expression of the specific trk receptors for nerve growth factor and brain-derived neurotrophic factor ( trk A and trk B) has been assayed by messenger RNA in situ hybridization in adult rats with partial fimbrial transections along with intraven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5764c49e743f077b92a77db765324f5
https://doi.org/10.1016/0306-4522(94)90285-2
https://doi.org/10.1016/0306-4522(94)90285-2
Publikováno v:
NeuroReport. 5:429-432
Expression of brain-derived neurotrophic factor (BDNF) in the ventral mesencephalon has been assayed by mRNA in situ hybridization in adult rats with unilateral injections of 6-hydroxydopamine in the substantia nigra. On contralateral control sides,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3182eb42fd5240a3af52698e9c62dae5
https://doi.org/10.1097/00001756-199401120-00014
https://doi.org/10.1097/00001756-199401120-00014
Autor:
Hans Rudolf Widmer, Franz Hefti, David L. Kaplan, Beat Knusel, Klaus D. Beck, Stuart J. Rabin
Publikováno v:
Journal of Neurochemistry. 60:2111-2123
Phospholipase C gamma 1 (PLC-gamma 1) is involved at an early step in signal transduction of many hormones and growth factors and catalyzes the hydrolysis of phosphatidylinositol (PI) 4,5-bisphosphate to diacylglycerol and inositol trisphosphate, two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec7084ca4f8c464a529086700468258
https://doi.org/10.1111/j.1471-4159.1993.tb03496.x
https://doi.org/10.1111/j.1471-4159.1993.tb03496.x