Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Klaus Borner"'
Single- and multiple-dose pharmacokinetics of linezolid and co-amoxiclav in healthy human volunteers
Autor:
Klaus Borner, Carl Erik Nord, Nicolas von der Höh, Olaf Burkhardt, Mathias W. Pletz, Peter Köppe, Hartmut Lode
Publikováno v:
Journal of Antimicrobial Chemotherapy. 50:707-712
In an open, randomized, two-period crossover study the pharmacokinetics of linezolid and co-amoxiclav were investigated after single- and multiple-dose administration in 12 healthy volunteers (six females and six males). Linezolid was given in tablet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35861f3afe4c3eeced2d0c77acee9a42
https://doi.org/10.1093/jac/dkf163
https://doi.org/10.1093/jac/dkf163
Publikováno v:
International Journal of Antimicrobial Agents. 18:253-258
An HPLC method is described for the determination of the new oxazolidinone antibiotic linezolid (I) in human biofluids. After precipitation of serum proteins with perchloric acid the protein free supernatant was separated by isocratic reversed-phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d741b4c33c629d462031237c73cde5cd
https://doi.org/10.1016/s0924-8579(01)00383-1
https://doi.org/10.1016/s0924-8579(01)00383-1
Publikováno v:
Scandinavian Journal of Infectious Diseases. 33:899-903
Twelve healthy subjects (6 females, 6 males; age range 18-40 y) participated in this trial. Linezolid was given as 600 mg tablets b.i.d. for 7 d and amoxicillin/clavulanic acid as 1000 mg tablets o.d. for 7 d. The washout period between the administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d8b56faeb8abc66e625cc09289ab11
https://doi.org/10.1080/00365540110076714
https://doi.org/10.1080/00365540110076714
Publikováno v:
Journal of Chromatography A. 846:175-180
For the quantitative determination of trovafloxacin (a new naphthyridinone antibacterial agent) in serum and urine a simple isocratic HPLC method with fluorimetric detection is described. Serum was deproteinised with a mixture of acetonitrile and per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06420c88d8d4144aa05851ccd8c9daf8
https://doi.org/10.1016/s0021-9673(99)00247-2
https://doi.org/10.1016/s0021-9673(99)00247-2
Autor:
Peter Koeppe, Carl Erik Nord, Jörg Luepke, Jörg Hamacher, Hartmut Lode, David R. Bristol, Klaus Borner, Bruce E. Reidenberg
Publikováno v:
Clinical Microbiology and Infection. 5(6):339-354
OBJECTIVE: To investigate changes in fecal flora and multiple-dose pharmacokinetics with the oral antibiotics ceftibuten 400 mg daily and cefpodoxime proxetil (CPX) 200 mg every 12 h, compared to amoxycillin/clavulanate 500/125 mg every 8 h during an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238da5ed62576f2429d1cbea2765c169
Publikováno v:
International Journal of Antimicrobial Agents. 11:75-79
A simple HPLC method is described for the determination of clofazimine in mouse tissues and in serum. The main application of the method was the determination of the drug in mouse tissues after i.v. administration of nanocrystalline suspensions or li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9386608990fd5005e2f0dcf6a1f6d1
https://doi.org/10.1016/s0924-8579(98)00065-x
https://doi.org/10.1016/s0924-8579(98)00065-x
Publikováno v:
Clinical Infectious Diseases. 27:33-39
Fluoroquinolone antimicrobial agents are highly active against aerobic or facultative gram-negative bacilli. The fluoroquinolones have been shown to be very concentration dependent in their rates of killing and also have a postantibiotic effect again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f9c9c5b6fedfb57e912ffef27747a9
https://doi.org/10.1086/514623
https://doi.org/10.1086/514623
Publikováno v:
Chromatographia. 47:171-175
A new and simple HPLC method is described for the separation and quantitative determination of the (+)-and (−)-enantiomers of lansoprazole. The analytes were extracted from serum as previously described for whole lansoprazole [K. Borner, Chromatogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4dadf83e8e08c67f09d1405fe9c5540
https://doi.org/10.1007/bf02466577
https://doi.org/10.1007/bf02466577
Autor:
Helmut Hahn, Stefan Ehlers, Klaus Borner, W. E. Bucke, Rainer H. Müller, S. Leitzke, J.E. Diederichs
Publikováno v:
Journal of Drug Targeting. 5:99-108
Amikacin-loaded liposomes were produced and surface-modified by adsorption of PEG 4000, Tween 80, poloxamer 407 and gelatin. The organ distribution was studied in mice by analysing the amikacin content in liver, spleen, lung, kidneys and serum. Highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0e47db03fa290993f9247c3c84efe1
https://doi.org/10.3109/10611869808995863
https://doi.org/10.3109/10611869808995863
Publikováno v:
European Respiratory Journal. 10:1130-1136
Sparfloxacin (SPX), a novel fluoroquinolone with a broad spectrum of antibacterial activity, has been shown, in vitro, to be more effective against common pulmonary pathogens, particularly Streptococcus pneumoniae, Mycoplasma pneumoniae and some intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d67739a8bc9d0eee4c852803f71bc9e
https://doi.org/10.1183/09031936.97.10051130
https://doi.org/10.1183/09031936.97.10051130