Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Klaus Benndorf"'
Autor:
Alessandro Porro, Andrea Saponaro, Roberta Castelli, Bianca Introini, Anahita Hafez Alkotob, Golnaz Ranjbari, Uta Enke, Jana Kusch, Klaus Benndorf, Bina Santoro, Dario DiFrancesco, Gerhard Thiel, Anna Moroni
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Binding of cAMP to Hyperpolarization activated cyclic nucleotide gated (HCN) channels facilitates pore opening. It is unclear why the isolated cyclic nucleotide binding domain (CNBD) displays in vitro lower affinity for cAMP than the full-le
Externí odkaz:
https://doaj.org/article/54ee296cfd5a4b9b8c10a343ba531e63
Autor:
Ralf Schmauder, Thomas Eick, Eckhard Schulz, Günther Sammler, Elmar Voigt, Günter Mayer, Holger Ginter, Günter Ditze, Klaus Benndorf
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Ligand-gated ion channels are formed by three to five subunits that control the opening of the pore in a cooperative fashion. We developed a microfluidic chip-based technique for studying ion currents and fluorescence signals in either excis
Externí odkaz:
https://doaj.org/article/22582074603742e0853cab621ad712b1
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 942 (2024)
P2X receptors are ATP-activated, non-specific cation channels involved in sensory signalling, inflammation, and certain forms of pain. Investigations of agonist binding and activation are essential for comprehending the fundamental mechanisms of rece
Externí odkaz:
https://doaj.org/article/7ef6aad9aa594ac2aedb1a9bac60a930
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/5f329009134c4108aa889803a1ddf473
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
FRET and confocal patch-clamp fluorometry in oocytes is used to analyze glutamateinduced conformational changes and dimerization of mGluR 1-8 homo- and heterodimers.
Externí odkaz:
https://doaj.org/article/4e888d40080344999b5b9ef0b7f02ab6
Autor:
Mahesh Kondapuram, Benedikt Frieg, Sezin Yüksel, Tina Schwabe, Christian Sattler, Marco Lelle, Andrea Schweinitz, Ralf Schmauder, Klaus Benndorf, Holger Gohlke, Jana Kusch
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Interactions between opposite subunits of HCN channels are relevant for stabilizing the auto-inhibited state of the channel. Like cAMP-binding, K464E-mutation breaks these interactions to favor a channel’s pre-activated state.
Externí odkaz:
https://doaj.org/article/4cd43313eb1744ae8c3bd4d84f1bb5b3
Autor:
Sezin Yüksel, Michele Bonus, Tina Schwabe, Christopher Pfleger, Thomas Zimmer, Uta Enke, Inga Saß, Holger Gohlke, Klaus Benndorf, Jana Kusch
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate electrical rhythmicity in special brain neurons and cardiomyocytes. The channels are activated by membrane hyperpolarization. The binding of cAMP to th
Externí odkaz:
https://doaj.org/article/9fd4821d4e2641c9a8abc668af73cd8c
Autor:
Jana Schirmeyer, Thomas Eick, Eckhard Schulz, Sabine Hummert, Christian Sattler, Ralf Schmauder, Klaus Benndorf
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010376 (2022)
Cyclic nucleotide-gated (CNG) ion channels of olfactory sensory neurons contain three types of homologue subunits, two CNGA2 subunits, one CNGA4 subunit and one CNGB1b subunit. Each subunit carries an intracellular cyclic nucleotide binding domain (C
Externí odkaz:
https://doaj.org/article/ebc7e5e9eecf4c9593cc5cb6b7fb22cd
Autor:
Christian Sattler, Thomas Eick, Sabine Hummert, Eckhard Schulz, Ralf Schmauder, Andrea Schweinitz, Christopher Unzeitig, Frank Schwede, Klaus Benndorf
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Ionotropic purinergic (P2X) receptors are trimeric channels that are activated by the binding of ATP. They are involved in multiple physiological functions, including synaptic transmission, pain and inflammation. The mechanism of activation
Externí odkaz:
https://doaj.org/article/1df92b225dd244dcb0623e62c017f5d8
Publikováno v:
eLife, Vol 11 (2022)
Inferring adequate kinetic schemes for ion channel gating from ensemble currents is a daunting task due to limited information in the data. We address this problem by using a parallelized Bayesian filter to specify hidden Markov models for current an
Externí odkaz:
https://doaj.org/article/1e4aebffc77a4df98bd4a019cbaa335e