Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Klaus A. Rytved"'
1
Reactive Oxygen Species-Responsive Polymer Nanoparticles to Improve the Treatment of Inflammatory Skin Diseases
Autor: Heidi K. Noddeland, Pernille Kemp, Andrew J. Urquhart, Andreas Herchenhan, Klaus A. Rytved, Karsten Petersson, Louise B. Jensen
Publikováno v: Noddeland, H K, Kemp, P, Urquhart, A J, Herchenhan, A, Rytved, K A, Petersson, K & Jensen, L B 2022, ' Reactive Oxygen Species-Responsive Polymer Nanoparticles to Improve the Treatment of Inflammatory Skin Diseases ', ACS Omega, vol. 7, no. 29, pp. 25055-25065 . https://doi.org/10.1021/acsomega.2c01071
Noddeland, H K, Kemp, P, Urquhart, A J, Herchenhan, A, Rytved, K A, Petersson, K & B. Jensen, L 2022, ' Reactive Oxygen Species-Responsive Polymer Nanoparticles to Improve the Treatment of Inflammatory Skin Diseases ', ACS Omega, vol. 7, no. 29, pp. 25055-25065 . https://doi.org/10.1021/acsomega.2c01071
To improve the quality of life for people living with chronic inflammatory skin diseases, we propose a new treatment strategy by exploring a stimuli-responsive drug delivery system. Formulations designed by exploiting smart materials can be programme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecddcef2c1ac57f1d1faed6c63187699
https://orbit.dtu.dk/en/publications/2018b4b7-354f-4b93-956f-94d56d9c4a20
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2
Fragment-Based Discovery of 6-Arylindazole JAK Inhibitors
Autor: Klaus A. Rytved, Andreas Ritzén, Morten Dahl Sørensen, Martin A. Carnerup, Daniel Rodriguez Greve, Anders Jerre, Jesper Bagger-Bahnsen, Dack Kevin Neil
Publikováno v: ACS Medicinal Chemistry Letters. 7:641-646
Janus kinase (JAK) inhibitors are emerging as novel and efficacious drugs for treating psoriasis and other inflammatory skin disorders, but their full potential is hampered by systemic side effects. To overcome this limitation, we set out to discover
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975300fad61e4a58f44e85530a0ccf4e
https://doi.org/10.1021/acsmedchemlett.6b00087
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5
PKPD Model of Interleukin-21 Effects on Thermoregulation in Monkeys—Application and Evaluation of Stochastic Differential Equations
Autor: Nicholas H. G. Holford, Henrik Madsen, Klaus A. Rytved, Rune Viig Overgaard
Publikováno v: Pharmaceutical Research. 24:298-309
Purpose. To describe the pharmacodynamic effects of recombinant human interleukin-21 (IL-21) on core body temperature in cynomolgus monkeys using basic mechanisms of heat regulation. A major effort was devoted to compare the use of ordinary different
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96370330881de11ceb34fa0dd1a9f0e
https://doi.org/10.1007/s11095-006-9143-x
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6
Non-linear mixed effects modeling of sparse concentration data from rats: Application to a glycogen phosphorylase inhibitor
Autor: Klaus A. Rytved, Lars Fogh Iversen, Steen H. Ingwersen, Michael P. Andersen, Yvonne Petersen, Benedicte Kiehr
Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 27:203-212
We investigated the use of non-linear mixed effects modeling in two preclinical studies of the glycogen phosphorylase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol (DAB). In a 28-day repeated-dose toxicity study rats were dosed once daily p.o. with 0,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e900acae623cec4f46e2daaf0b8510e0
https://doi.org/10.1007/bf03190459
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7
EP 3 receptors inhibit antidiuretic-hormone-dependent sodium transport across frog skin epithelium
Autor: Robert Nielsen, Klaus A. Rytved
Publikováno v: Pfl�gers Archiv European Journal of Physiology. 437:213-218
We examined the effect of prostaglandin E2 (PGE2) on antidiuretic hormone (ADH)-dependent Na+ transport and cAMP production in isolated frog skin epithelium. ADH caused an increase in transepithelial Na+ transport and a decrease in cellular potential
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d26b7df087aaef316215f8dbabb9c7
https://doi.org/10.1007/s004240050771
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8
Prostaglandin E2release from dermis regulates sodium permeability of frog skin epithelium
Autor: Klaus A. Rytved, Birger Brodin, Robert Nielsen
Publikováno v: Acta Physiologica Scandinavica. 153:263-270
In the present study we have compared the effects of increased intracellular Ca 2+ in whole frog skin and isolated epithelium (Rana temporaria). Cellular Ca 2+ was increased by the use of the endoplasmic reticulum Ca 2+ ATPase inhibitor, thapsigargin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4680653b310d98194df4c0ff5dbd41
https://doi.org/10.1111/j.1748-1716.1995.tb09862.x
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9
Intracellular calcium modulates basolateral K+-permeability in frog skin epithelium
Autor: Robert Nielsen, Klaus A. Rytved, Birger Brodin
Publikováno v: Pfl�gers Archiv European Journal of Physiology. 426:171-173
Cytosolic calcium ([Ca2+]i) has been suggested as a key modulator in the regulation of active sodium transport across electrically "tight" (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiologi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ff8a8a095e401bcdd91335e82a481a
https://doi.org/10.1007/bf00374685
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10
An increase in [Ca2+]i activates basolateral chloride channels and inhibits apical sodium channels in frog skin epithelium
Autor: Klaus A. Rytved, Robert Nielsen, Birger Brodin
Publikováno v: Pflugers Archiv : European journal of physiology. 433(1-2)
The aim of this study was to investigate the mechanisms by which increases in free cytosolic calcium ([Ca2+]i) cause a decrease in macroscopic sodium absorption across principal cells of the frog skin epithelium. [Ca2+]i was measured with fura-2 in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c6f32cc68d94bd5aa0eba09f987bcd
https://pubmed.ncbi.nlm.nih.gov/9019717
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