Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of k18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2

Autor: Gary Ewart, Michael Bobardt, Bo Hjorth Bentzen, Yannan Yan, Audrey Thomson, Klaus Klumpp, Stephen Becker, Mette M. Rosenkilde, Michelle Miller, Philippe Gallay

The Coronavirus envelope (E) protein is a small structural protein with ion channel activity that plays an important role in virus assembly, budding, immunopathogenesis and disease severity. The viroporin E is also located in Golgi and ER membranes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::813ca030c98b2651f3d9953b25c26d1d
https://doi.org/10.1101/2023.03.29.534854

SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators

Autor: Scott D. Kuduk, Vincent Lau, Osvaldo Flores, Christine Espiritu, Robert Vogel, Angela M. Lam, George D. Hartman, Klaus Klumpp

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:2405-2409

The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly process has shown clinical efficacy in earl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2146095186499eb78cb90423f3a153b7
https://doi.org/10.1016/j.bmcl.2019.05.029

Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19

Autor: Jian Zheng, Lok-Yin Roy Wong, Kevin Wilhelmsen, Kun Li, Miguel E Ortiz, Nicholas J Schnicker, Andrew Thurman, Alejandro A Pezzulo, Peter J Szachowicz, Pengfei Li, Ruangang Pan, Klaus Klumpp, Fred Aswad, Justin Rebo, Shuh Narumiya, Makoto Murakami, Sonia Zuniga, Isabel Sola, Luis Enjuanes, David K Meyerholz, Kristen Fortney, Paul B McCray, Stanley Perlman

Publikováno v: The Journal of Immunology. 208:125.05-125.05

Coronavirus disease 2019 (COVID-19) is especially severe in aged populations. Resolution of the COVID-19 pandemic has been advanced by the recent development of SARS-CoV-2 vaccines, but vaccine efficacy is partly compromised by the recent emergence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8469c7c3dbcb9665c53c1b87415be8df
https://doi.org/10.4049/jimmunol.208.supp.125.05

H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load

Autor: Adrianus C. M. Boon, David Finkelstein, Ming Zheng, Guochun Liao, John Allard, Klaus Klumpp, Robert Webster, Gary Peltz, Richard J. Webby

Publikováno v: mBio, Vol 2, Iss 5 (2011)

ABSTRACT The genotype of the host is one of several factors involved in the pathogenesis of an infectious disease and may be a key parameter in the epidemiology of highly pathogenic H5N1 influenza virus infection in humans. Gene polymorphisms may aff

Externí odkaz: https://doaj.org/article/3a9487f42a7647bf9dbb2acaf2b7d349

Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection

Autor: Michel Rivoire, Angela Lam, Romain Parent, Nathalie Bendriss-Vermare, Danijela Heide, Julie Lucifora, Matthias S. Matter, Ludovic Aillot, Klaus Klumpp, Fabien Zoulim, Fanny Lebossé, Lalo Flores, Laura Dimier, Judith Fresquet, Anna Salvetti, Suzanne Faure-Dupuy, David Durantel, Marion Delphin, Mathias Heikenwalder

Publikováno v: Journal of Hepatology
Journal of Hepatology, Elsevier, 2019, 71 (6), pp.1086-1098. ⟨10.1016/j.jhep.2019.06.032⟩
Journal of Hepatology, 2019, 71 (6), pp.1086-1098. ⟨10.1016/j.jhep.2019.06.032⟩

Background & Aims Liver macrophages can be involved in both pathogen clearance and/or pathogenesis. To get further insight on their role during chronic hepatitis B virus (HBV) infections, our aim was to phenotypically and functionally characterize in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de13ca04bbfb190fec9605312c863da6
https://hal.archives-ouvertes.fr/hal-03315737