Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Klaus Charisse"'
Autor:
Linda L. Kusner, Kristina Yucius, Manjistha Sengupta, Andrew G. Sprague, Dhruv Desai, Tuyen Nguyen, Klaus Charisse, Satya Kuchimanchi, Rajeev Kallanthottathil, Kevin Fitzgerald, Henry J. Kaminski, Anna Borodovsky
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 484-492 (2019)
Complement-mediated damage to the neuromuscular junction (NMJ) is a key mechanism of pathology in myasthenia gravis (MG), and therapeutics inhibiting complement have shown evidence of efficacy in the treatment of MG. In this study, we describe the de
Externí odkaz:
https://doaj.org/article/44b70ce344d04d39ba586958c5169aed
Autor:
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L. S. Willoughby, Nate Taneja, Jonathan O’Shea, Anna Bisbe, Rajar M. Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A. Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K. Nair, Klaus Charisse, Martin A. Maier, Kallanthottathil G. Rajeev, Martin Egli, Muthiah Manoharan
Publikováno v:
Journal of Medicinal Chemistry. 66:2506-2523
Autor:
Dale C. Guenther, Shohei Mori, Shigeo Matsuda, Jason A. Gilbert, Jennifer L. S. Willoughby, Sarah Hyde, Anna Bisbe, Yongfeng Jiang, Saket Agarwal, Mimouna Madaoui, Maja M. Janas, Klaus Charisse, Martin A. Maier, Martin Egli, Muthiah Manoharan
Publikováno v:
Journal of the American Chemical Society. 144:14517-14534
Autor:
Long-Cheng Li, Muthiah Manoharan, Hila Epstein-Barash, Klaus Charisse, Robert F. Place, Glen Yang, Moo Rim Kang
PDF file - 24K, Oligonucleotide sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913db90b952865e458f233dc3b5629dd
https://doi.org/10.1158/0008-5472.22395959
https://doi.org/10.1158/0008-5472.22395959
Autor:
Long-Cheng Li, Muthiah Manoharan, Hila Epstein-Barash, Klaus Charisse, Robert F. Place, Glen Yang, Moo Rim Kang
PDF file - 687K, Figure S1. dsP21-322 triggers changes in cell morphology associated with growth inhibition. Figure S2. Anti-growth activities of LNP-dsP21-322-2'F and its non-formulated derivatives. Figure S3. Duplex stability in water and detection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce2485c026bec3bbaea8dbd51cb182d
https://doi.org/10.1158/0008-5472.22395965
https://doi.org/10.1158/0008-5472.22395965
The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
Autor:
Mehrpouya B. Mobin, Stefanie Gerstberger, Daniel Teupser, Benedetta Campana, Klaus Charisse, Markus H. Heim, Muthiah Manoharan, Thomas Tuschl, Markus Stoffel
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
RNA-binding proteins (RBP) are an emerging group of post-translational regulators. Here the authors show that the RBP vigilin regulates translation of mRNA encoding for proatherogenic proteins—apoB, apoC-III and fibronectin—representing a potenti
Externí odkaz:
https://doaj.org/article/c051eb85ce414e1e9cc79d1170727a36
Autor:
Shubaash Anthiya, Süleyman Can Öztürk, Hamdullah Yanik, Ece Tavukcuoglu, Adem Şahin, Dhrubajyoti Datta, Klaus Charisse, David Moreira Álvarez, María Isabel Loza, Alfonso Calvo, Einar Sulheim, Simon Loevenich, Geir Klinkenberg, Ruth Schmid, Muthiah Manoharan, Güneş Esendağlı, Maria Jose Alonso
K-RAS is a highly relevant oncogene that is mutated in approximately 90% of pancreatic cancers and 20–25% of lung adenocarcinomas. The aim of this work was to develop a new anti-KRAS siRNA therapeutic strategy through the engineering of functionali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d546c8f9a778fb6999cb14a0ee3108
https://hdl.handle.net/10347/30619
https://hdl.handle.net/10347/30619
Autor:
Sarah, Engelbeen, Svetlana, Pasteuning-Vuhman, Joke, Boertje-van der Meulen, Rubina, Parmar, Klaus, Charisse, Laura, Sepp-Lorenzino, Muthiah, Manoharan, Annemieke, Aartsma-Rus, Maaike, van Putten
Publikováno v:
Nucleic acid therapeutics.
Downregulation of genes involved in the secondary pathology of Duchenne muscular dystrophy, for example, inflammation, fibrosis, and adiposis, is an interesting approach to ameliorate degeneration of muscle and replacement by fibrotic and adiposis ti
Autor:
Sarah Engelbeen, Svetlana Pasteuning-Vuhman, Joke Boertje-van der Meulen, Rubina Parmar, Klaus Charisse, Laura Sepp-Lorenzino, Muthiah Manoharan, Annemieke Aartsma-Rus, Maaike van Putten
Publikováno v:
Nucleic Acid Therapeutics, 33(1). MARY ANN LIEBERT, INC
Downregulation of genes involved in the secondary pathology of Duchenne muscular dystrophy, for example, inflammation, fibrosis, and adiposis, is an interesting approach to ameliorate degeneration of muscle and replacement by fibrotic and adiposis ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0146c2df99039b4961c0815ac1d31b9f
https://doi.org/10.1089/nat.2022.0021
https://doi.org/10.1089/nat.2022.0021