Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Klaus Albertshofer"'
Publikováno v:
Organic Letters. 15:2958-2961
An efficient organocatalytic asymmetric [3 + 2] cycloaddition reaction between 3-substituted methylenebenzofuranone derivatives and diverse Morita-Baylis-Hillman carbonates to provide complex polysubstituted spirocyclopentenebenzofuranone scaffolds i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f029fdbf3802a133c27af754a83e1c2
https://doi.org/10.1021/ol401087a
https://doi.org/10.1021/ol401087a
Publikováno v:
ChemInform. 47
Lithium tetramethylpiperidide is found to efficiently promote the regioselective fluorination of N-protected 2-substituted imidazoles (I) and (IV) to give the products regioselectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6797a39c8409e8b33c417bbf3be8614b
https://doi.org/10.1002/chin.201626149
https://doi.org/10.1002/chin.201626149
Publikováno v:
The Journal of organic chemistry. 81(3)
We report the regioselective and direct functionalization of rationally designed imidazole derivatives through electrophilic fluorination with N-fluorobenzenesulfonimide enabled via in situ deprotonation with lithium 2,2,6,6-tetramethylpiperidine. Ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f832c5f402b529a3e9854dcb89108fc
https://pubmed.ncbi.nlm.nih.gov/26741948
https://pubmed.ncbi.nlm.nih.gov/26741948
Autor:
Theodore M. Winger, Timothy A. Vickers, Brett P. Monia, Klaus Albertshofer, Andrew M. Siwkowski, Andres Berdeja, Jiaxin Hu, C. Frank Bennett, David R. Corey, Eric E. Swayze, Christopher J. Nulf, Hans Gaus, Garth A. Kinberger, Edward Wancewicz, Martin Maier, Richard H. Griffey
Publikováno v:
Journal of Medicinal Chemistry. 53:3919-3926
A peptide nucleic acid (PNA) targeting a splice junction of the murine PTEN primary transcript was covalently conjugated to various basic peptides. When systemically administered to healthy mice, the conjugates displayed sequence-specific alteration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714ccdda4222553ada2218adbc94528e
https://doi.org/10.1021/jm901489k
https://doi.org/10.1021/jm901489k
Autor:
Carlos F. Barbas, Naoto Utsumi, Fujie Tanaka, Haile Zhang, Paul Ha-Yeon Cheong, Klaus Albertshofer, Susumu Mitsumori, Maria Mifsud, Masanori Imai, Kendall N. Houk, Noemi Garcia-Delgado
Publikováno v:
Journal of the American Chemical Society. 130:875-886
The development of enantioselective anti-selective Mannich-type reactions of aldehydes and ketones with imines catalyzed by 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives is reported in detail. Both (3R,5R)-5-methyl-3-pyrrolidinecar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b3a0a4c219aa376d4c2bd429f6012a6
https://doi.org/10.1021/ja074907+
https://doi.org/10.1021/ja074907+
Publikováno v:
The Journal of Organic Chemistry. 71:3822-3828
Dihydroxyacetone variants have been explored as donors in organocatalytic aldol reactions with various aldehyde and ketone acceptors. The protected form of dihydroxyacetone that was chosen for in-depth study was 2,2-dimethyl-1,3-dioxan-5-one, 1. Amon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0944c06e39a5b3a34fedd5b2a602c67d
https://doi.org/10.1021/jo0602017
https://doi.org/10.1021/jo0602017
Autor:
Garth A. Kinberger, Tanya Watanabe, Andrew M. Siwkowski, Klaus Albertshofer, Neena S. Kadaba, C. Frank Bennett, Christine Esau, Richard H. Griffey, Martin Maier, Muthiah Manoharan, Edward Wancewicz, Eric E. Swayze
Publikováno v:
Journal of Medicinal Chemistry. 49:2534-2542
Cellular permeation peptides have been used successfully for the delivery of a variety of cargoes across cellular membranes, including large hydrophilic biomolecules such as proteins, oligonucleotides, or plasmid DNA. For the present work, a series o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b15433df0eb966674dff8159505d21
https://doi.org/10.1021/jm051275y
https://doi.org/10.1021/jm051275y
Autor:
Kenji C Nishihara, Klaus Albertshofer, Brett P. Monia, Eric E. Swayze, Martin Maier, Leila Malik, Andrew M. Siwkowski, C. Frank Bennett, Anne B. Eldrup, Edward Wancewicz, Garth A. Kinberger, Richard S. Geary, Christine Esau, Richard H. Griffey, Muthiah Manoharan, Tanya Watanabe
Publikováno v:
Journal of Medicinal Chemistry. 48:6741-6749
Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of peptide nucleic acids (PNAs) as antisense therapeutics. Recently, we reported the identification and functional characterizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99435f07c1247e482294ae1976ff9413
https://doi.org/10.1021/jm050490b
https://doi.org/10.1021/jm050490b
Autor:
Brett P. Monia, Edward Wancewicz, Leila Malik, Martin Maier, Anne B. Eldrup, C. Frank Bennett, Christine Esau, Klaus Albertshofer, Andrew M. Siwkowski
Publikováno v:
Nucleic Acids Research. 32:2695-2706
Cognate recognition between the CD40 receptor and its ligand, CD154, is thought to play a central role in the initiation and propagation of immune responses. We describe the specific down regulation of cell surface associated CD40 protein expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00938a99b5d71f7fdaa4c0e1ab67d9eb
https://doi.org/10.1093/nar/gkh584
https://doi.org/10.1093/nar/gkh584
Publikováno v:
ChemInform. 44
Benzofuranone derivatives (I) undergo [3 + 2] cycloaddition with Morita—Baylis—Hillman carbonates in the presence of a chiral 1,2-ethanediylphospholane as catalyst under mild conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3beafcb0143b84dbe68c871f1ecea338
https://doi.org/10.1002/chin.201346100
https://doi.org/10.1002/chin.201346100