Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Klaus Überla"'
Autor:
Jannik T. Wagner, Sandra M. Müller-Schmucker, Wenjun Wang, Philipp Arnold, Nadja Uhlig, Leila Issmail, Valentina Eberlein, Dominik Damm, Kaveh Roshanbinfar, Armin Ensser, Friederike Oltmanns, Antonia Sophia Peter, Vladimir Temchura, Silke Schrödel, Felix B. Engel, Christian Thirion, Thomas Grunwald, Manfred Wuhrer, Dirk Grimm, Klaus Überla
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Long-acting passive immunization strategies are needed to protect immunosuppressed vulnerable groups from infectious diseases. To further explore this concept for COVID-19, we constructed Adeno-associated viral (AAV) vectors encoding the hum
Externí odkaz:
https://doaj.org/article/fb0eb88696d04de18d534ac0c445bf7a
Autor:
Riccardo Di Vincenzo, Jannis Beutel, Philipp Arnold, Yu Wang, Dominik Damm, Pierre Tannig, Anja Lux, Vladimir Temchura, Jutta Eichler, Klaus Überla
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionConformationally stabilized Env trimers have been developed as antigens for the induction of neutralizing antibodies against HIV-1. However, the non-glycosylated immunodominant base of these soluble antigens may compete with the neutraliz
Externí odkaz:
https://doaj.org/article/2571239df4064bf6a4a340badd9701ae
Autor:
Felix Werner, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla, Isabelle Kaiser, Maria Sebastião, Susann Hueber, Lisette Warkentin
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background In the course of the SARS-CoV-2 pandemic, multiple vaccines were developed. Little was known about reactogenicity and safety in comparison to established vaccines, e.g. influenza, pneumococcus, or herpes zoster. Therefore, the pre
Externí odkaz:
https://doaj.org/article/2329368c2d954ea093bacde0eeb080d3
Autor:
Lisette Warkentin, Felix Werner, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla, Isabelle Kaiser, Maria Sebastião, Susann Hueber
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Since the beginning of the COVID-19 vaccination campaigns, recommendations regarding the vaccination have been very dynamic. Although the safety and efficacy of different vaccines have been analysed, data were scarce for vaccine r
Externí odkaz:
https://doaj.org/article/19f2ddfe09bd44feaab6ce215100e75a
Autor:
Elie Richel, Jannik T. Wagner, Stephan Klessing, Riccardo Di Vincenzo, Vladimir Temchura, Klaus Überla
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundFc-fusion proteins have been successfully developed for therapeutic purposes, but are also a promising platform for the fast generation and purification of immunogens capable of inducing strong humoral immune responses in preclinical immuni
Externí odkaz:
https://doaj.org/article/fa5e0200210546b9819e91d6c35e2062
Autor:
David Peterhoff, Simon Wiegrebe, Sebastian Einhauser, Arisha J. Patt, Stephanie Beileke, Felix Günther, Philipp Steininger, Hans H. Niller, Ralph Burkhardt, Helmut Küchenhoff, Olaf Gefeller, Klaus Überla, Iris M. Heid, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
SARS-CoV-2 antibody quantity and quality are key markers of humoral immunity. However, there is substantial uncertainty about their durability. We investigated levels and temporal change of SARS-CoV-2 antibody quantity and quality. We analyzed sera (
Externí odkaz:
https://doaj.org/article/9527678d20b44a4db0bce5077cc7d4ee
Autor:
Kira J Stanzick, Josef Simon, Martina E Zimmermann, Michael Schachtner, David Peterhoff, Hans-Helmut Niller, Klaus Überla, Ralf Wagner, Iris M Heid, Klaus J Stark
Publikováno v:
BioTechniques, Vol 74, Iss 1, Pp 23-29 (2023)
DNA extraction from frozen blood clots is challenging. Here, the authors applied QIAGEN Clotspin Baskets and the Gentra Puregene Blood Kit for DNA extraction to cellular fraction of 5.5 ml whole blood without anticoagulating additives. The amount and
Externí odkaz:
https://doaj.org/article/7b83778b788149ef807ab12cd503ef22
Autor:
Nikoletta Zeschick, Lisette Warkentin, Thomas Kühlein, Philipp Steininger, Klaus Überla, Susann Hueber, Maria Sebastião
Publikováno v:
Pilot and Feasibility Studies, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Background The Corona-Vakzin-Konsortium project (CoVaKo) analyses the efficacy and safety of COVID-19 vaccines in a real-world setting, as well as breakthrough infections in Bavaria, Germany. A subproject of CoVaKo aims to identify adverse r
Externí odkaz:
https://doaj.org/article/794099d994ac45c3beb589f912a8b697
Autor:
Lisette Warkentin, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla, Isabelle Kaiser, Christine Gall, Maria Sebastião, Susann Hueber
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Due to safety signals after vaccination with COVID-19 vector vaccines, several states recommended to complete the primary immunization series in individuals having received one dose of ChAdOx1 (AstraZeneca) with an mRNA vaccine. H
Externí odkaz:
https://doaj.org/article/3d0bf8ee710945a4a71077644f7788a1
Autor:
Dennis Lapuente, Jana Fuchs, Jonas Willar, Ana Vieira Antão, Valentina Eberlein, Nadja Uhlig, Leila Issmail, Anna Schmidt, Friederike Oltmanns, Antonia Sophia Peter, Sandra Mueller-Schmucker, Pascal Irrgang, Kirsten Fraedrich, Andrea Cara, Markus Hoffmann, Stefan Pöhlmann, Armin Ensser, Cordula Pertl, Torsten Willert, Christian Thirion, Thomas Grunwald, Klaus Überla, Matthias Tenbusch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
While current COVID-19 vaccines provide certain protection, more effective vaccination strategies are still desirable. Here the authors show, using mouse vaccination models, that priming with a systemic mRNA and boosting with an intranasal adenoviral
Externí odkaz:
https://doaj.org/article/2d658f5bfe1141c4acf2fa4bf72300b6