Výsledky vyhledávání - "Klaus, Urbahns"

The expanding role for small molecules in immuno-oncology

Autor: Rienk Offringa, Lisa Kötzner, Bayard Huck, Klaus Urbahns

Publikováno v: Nature reviews. Drug discovery. 21(11)

The advent of immune checkpoint inhibition (ICI) using antibodies against PD1 and its ligand PDL1 has prompted substantial efforts to develop complementary drugs. Although many of these are antibodies directed against additional checkpoint proteins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34743fad8de69382360bb69ccf280ad
https://pubmed.ncbi.nlm.nih.gov/35982333

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Stable and Storable N(CF 3 ) 2 Transfer Reagents

Autor: Johannes Landmann, Tanja Knuplez, Christoph Kerpen, Nikolai V. Ignat'ev, Ludwig Zapf, Rüdiger Bertermann, Kristina A. M. Maibom, Tobias Bischof, Fabian Keppner, Eva-Maria Tanzer Krauel, Carl Deutsch, Leon Schneider, Klaus Urbahns, Michael Hailmann, Maik Finze

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)

Fluorinated groups are essential for drug design, agrochemicals, and materials science. The bis(trifluoromethyl)amino group is an example of a stable group that has a high potential. While the number of molecules containing perfluoroalkyl, perfluoroa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4a7cbb2b72ad5af348d43556e67a89
https://doi.org/10.1002/chem.202101436

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Akademický článek

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

Publikováno v: eLife, Vol 5 (2016)

Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will impact on the clinical utility of CDK8/19 inhibitors. We

Externí odkaz: https://doaj.org/article/a201fbf6b4ca430996a70dd003f4f498

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Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases

Publikováno v: Journal of Medicinal Chemistry. 62:7643-7655

Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib hold a prominent role in the treatment of B cell malignancies. However, further refinement is needed to this class of agents, particularly in terms of adverse events (potentially driven by k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb51d59d700ed35c9b5eb75576ca2e2d
https://doi.org/10.1021/acs.jmedchem.9b00794

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Targeted Covalent Inhibitors for the Treatment of Malaria?

Autor: Shashank Kulkarni, Thomas Spangenberg, Klaus Urbahns

Publikováno v: ACS infectious diseases. 6(11)

Malaria is a vector-borne disease caused by protozoan parasites of the genus Plasmodium. According to the World Health Organization, it is one of the most serious infectious diseases threatening mo...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b770aa85fce1771b378ba8c2f00f601
https://pubmed.ncbi.nlm.nih.gov/33054158

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Small molecules-Giant leaps for immuno-oncology

Autor: Lisa, Kötzner, Bayard, Huck, Sakshi, Garg, Klaus, Urbahns

Publikováno v: Progress in medicinal chemistry. 59

Immuno-oncology therapies are revolutionizing the oncology landscape with checkpoint blockade becoming the treatment backbone for many indications. While inspiring, much work remains to increase the number of cancer patients that can benefit from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::837fac698ac6e4ffec531726af3349a8
https://pubmed.ncbi.nlm.nih.gov/32362326

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Crystalline Sponges as a Sensitive and Fast Method for Metabolite Identification: Application to Gemfibrozil and its Phase I and II Metabolites

Autor: Clemens Kühn, Lassina Badolo, Lara Rosenberger, Klaus Urbahns, Anupam Khutia, Katrin Georgi, Carolina von Essen, Rolf W. Hartmann

Publikováno v: Drug Metabolism and Disposition

Understanding the metabolism of new drug candidates is important during drug discovery and development, as circulating metabolites may contribute to efficacy or cause safety issues. In the early phase of drug discovery, human in vitro systems are use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9f7b5847909700c43103e321c3a1ba
https://pubmed.ncbi.nlm.nih.gov/32434832

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Small molecules—Giant leaps for immuno-oncology

Autor: Bayard R. Huck, Sakshi Garg, Lisa Kötzner, Klaus Urbahns

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0309c749df2c83fff3e7d3758a7eab1
https://doi.org/10.1016/bs.pmch.2019.11.001

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Small Molecules Drive Big Improvements in Immuno-Oncology Therapies

Autor: Bayard R. Huck, Klaus Urbahns, Lisa Kötzner

Publikováno v: Angewandte Chemie (International Ed. in English)

Immuno‐oncology therapies have the potential to revolutionize the armamentarium of available cancer treatments. To further improve clinical response rates, researchers are looking for novel combination regimens, with checkpoint blockade being used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b0108d2bfa79105b8a5918b113b7a3
https://doi.org/10.1002/anie.201707816

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