Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Klaus, Strebhardt"'
Autor:
Monika Raab, Izabela Kostova, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Seyed Mohsen Aberoumandi, Evelyn Ullrich, Sven Becker, Mourad Sanhaji, Klaus Strebhardt
Publikováno v:
Cancer Communications, Vol 44, Iss 1, Pp 101-126 (2024)
Abstract Background The cellular tumor protein p53 (TP53) is a tumor suppressor gene that is frequently mutated in human cancers. Among various cancer types, the very aggressive high‐grade serous ovarian carcinoma (HGSOC) exhibits the highest preva
Externí odkaz:
https://doaj.org/article/cdcbdaaef4af4c5cad1851cbfb3a4e85
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Activation of T cells in the tumor microenvironment can be inhibited through a variety of mechanisms. Here, the authors show that Rasal1, a GTPase-activating protein, binds and inhibits signaling downstream of the T Cell Receptor complex and that con
Externí odkaz:
https://doaj.org/article/5e3f7af3677d4cc6984ba9564955a165
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract While the immune cell adaptor protein SKAP1 mediates LFA-1 activation induced by antigen-receptor (TCR/CD3) ligation on T-cells, it is unclear whether the adaptor interacts with other mediators of T-cell function. In this context, the serine
Externí odkaz:
https://doaj.org/article/b50da4e16a664a14a971d8a9772fdbb6
Autor:
Monika Raab, Mourad Sanhaji, Shengtao Zhou, Franz Rödel, Ahmed El-Balat, Sven Becker, Klaus Strebhardt
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 4, Pp 363-375 (2019)
Paclitaxel is a frontline drug for the treatment of epithelial ovarian cancer (EOC). However, following paclitaxel-platinum based chemotherapy, tumor recurrence occurs in most ovarian cancer patients. Chromosomal instability (CIN) is a hallmark of ca
Externí odkaz:
https://doaj.org/article/8a22921e22854a7892573ef4c3da59b1
Autor:
Franz Rödel, Shengtao Zhou, Balász Győrffy, Monika Raab, Mourad Sanhaji, Ranadip Mandal, Daniel Martin, Sven Becker, Klaus Strebhardt
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Since type and duration of an appropriate adjuvant chemotherapy in early-stage ovarian cancer (OC) are still being debated, novel markers for a better stratification of these patients are of utmost importance for the design of an improved chemotherap
Externí odkaz:
https://doaj.org/article/93cf63b38a824a33a0f7a987b5777ec1
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018)
Abstract Objective Immune cell adaptor protein SKAP1 couples the antigen-receptor (TCR/CD3) with the activation of LFA-1 adhesion in T-cells. Previous work by ourselves and others have shown that SKAP1 can directly bind to other adaptors such as ADAP
Externí odkaz:
https://doaj.org/article/12221994293d47f7924ee5903410045f
Autor:
Monika Raab, Mourad Sanhaji, Yves Matthess, Albrecht Hörlin, Ioana Lorenz, Christina Dötsch, Nils Habbe, Oliver Waidmann, Elisabeth Kurunci-Csacsko, Ron Firestein, Sven Becker, Klaus Strebhardt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The overexpression of Polo-like kinase 1 (Plk1) promotes various cancers in humans; sporadic evidence suggests Plk1 could act as a tumor suppressor but the molecular basis for this effect are unclear. Here the authors show that Plk1 inhibition augmen
Externí odkaz:
https://doaj.org/article/a03432a0fac04ac49c63a7cf0e5451dc
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of th
Externí odkaz:
https://doaj.org/article/4c73c60958e443bda720387ec3ccab2c
Autor:
Max Fleischmann, Daniel Martin, Samuel Peña-Llopis, Julius Oppermann, Jens von der Grün, Markus Diefenhardt, Georgios Chatzikonstantinou, Emmanouil Fokas, Claus Rödel, Klaus Strebhardt, Sven Becker, Franz Rödel, Nikolaos Tselis
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Introduction: Definitive chemoradiation (CRT) followed by high-dose-rate (HDR) brachytherapy (BT) represents state-of-the-art treatment for locally-advanced cervical cancer. Despite use of this treatment paradigm, disease-related outcomes have stagna
Externí odkaz:
https://doaj.org/article/f03486316d764622a0a9ab2bf93fd9f0
Publikováno v:
Cells, Vol 10, Iss 5, p 1176 (2021)
Polo-like kinases (PLKs) belong to a five-membered family of highly conserved serine/threonine kinases (PLK1-5) that play differentiated and essential roles as key mitotic kinases and cell cycle regulators and with this in proliferation and cellular
Externí odkaz:
https://doaj.org/article/8771222b5f17450782b0fcef69432fc7