Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Klaus, Scholich"'
Autor:
Maksim Sendetski, Saskia Wedel, Kenta Furutani, Lisa Hahnefeld, Carlo Angioni, Jan Heering, Béla Zimmer, Sandra Pierre, Alexandra-Maria Banica, Klaus Scholich, Sorin Tunaru, Gerd Geisslinger, Ru-Rong Ji, Marco Sisignano
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110552- (2024)
Summary: Noxious stimuli activate nociceptive sensory neurons, causing action potential firing and the release of diverse signaling molecules. Several peptides have already been identified to be released by sensory neurons and shown to modulate infla
Externí odkaz:
https://doaj.org/article/9870422af084425992e7ef7e3feb5b83
Autor:
Joschua Friedel, Sandra Pierre, Anja Kolbinger, Tim J. Schäufele, Blerina Aliraj, Andreas Weigert, Klaus Scholich
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionDuring an innate inflammation, immune cells form distinct pro- and anti-inflammatory regions around pathogen-containing core-regions. Mast cells are localized in an anti-inflammatory microenvironment during the resolution of an innate inf
Externí odkaz:
https://doaj.org/article/4946d48705c9429db4fe3838195d2a2b
Autor:
Anja Kolbinger, Tim J Schäufele, Hanna Steigerwald, Joschua Friedel, Sandra Pierre, Gerd Geisslinger, Klaus Scholich
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-17 (2022)
Abstract Pathogen‐induced inflammation comprises pro‐ and anti‐inflammatory processes, which ensure pathogen removal and containment of the proinflammatory activities. Here, we aimed to identify the development of inflammatory microenvironments
Externí odkaz:
https://doaj.org/article/498a7c3b871e4cb6bba74af3f2022d42
Autor:
Oliver FitzGerald, Frank Behrens, Anne Barton, Heidi Bertheussen, Bruno Boutouyrie-Dumont, Laura Coates, Owen Davies, Maarten de Wit, Filippo Fagni, Carl S. Goodyear, Robert Gurke, Lisa Hahnefeld, Christine Huppertz, Vassilios Ioannidis, Mark Ibberson, Arnon Katz, Maximilian Klippstein, Michaela Koehm, Shimon Korish, Sina Mackay, David A. Martin, Denis O’Sullivan, Khadijah Patel, Stefan Rueping, Georg Schett, Klaus Scholich, Jochen M. Schwenk, Stefan Siebert, David Simon, Arani Vivekanantham, Stephen R. Pennington
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 15 (2023)
Achieving a good outcome for a person with Psoriatic Arthritis (PsA) is made difficult by late diagnosis, heterogenous clinical disease expression and in many cases, failure to adequately suppress inflammatory disease features. Single-centre studies
Externí odkaz:
https://doaj.org/article/a667e6ccef804442bb02abacbd1a08bf
Autor:
Erika Dorochow, Nico Kraus, Nicolas Chenaux-Repond, Sandra Pierre, Anja Kolbinger, Gerd Geisslinger, Cristina Ortiz, Christoph Welsch, Jonel Trebicka, Robert Gurke, Lisa Hahnefeld, Sabine Klein, Klaus Scholich
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10351 (2023)
Non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH) are the leading causes of liver disease worldwide. To identify disease-specific pathomechanisms, we analyzed the lipidome, metabolome and immune cell recruitment in livers in bo
Externí odkaz:
https://doaj.org/article/4acf9d0679674ba2ab8d69572f73d6b0
Autor:
Robert Gurke, Annika Bendes, John Bowes, Michaela Koehm, Richard M. Twyman, Anne Barton, Dirk Elewaut, Carl Goodyear, Lisa Hahnefeld, Rainer Hillenbrand, Ewan Hunter, Mark Ibberson, Vassilios Ioannidis, Sabine Kugler, Rik J. Lories, Eduard Resch, Stefan Rüping, Klaus Scholich, Jochen M. Schwenk, James C. Waddington, Phil Whitfield, Gerd Geisslinger, Oliver FitzGerald, Frank Behrens, Stephen R. Pennington
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2387 (2022)
The definitive diagnosis and early treatment of many immune-mediated inflammatory diseases (IMIDs) is hindered by variable and overlapping clinical manifestations. Psoriatic arthritis (PsA), which develops in ~30% of people with psoriasis, is a key e
Externí odkaz:
https://doaj.org/article/8ed947e41a664f22a2b952f33211051f
Autor:
Lisa Kornstädt, Sandra Pierre, Andreas Weigert, Stefanie Ebersberger, Tim J. Schäufele, Anja Kolbinger, Tobias Schmid, Jennifer Cohnen, Dominique Thomas, Nerea Ferreirós, Bernhard Brüne, Ingo Ebersberger, Klaus Scholich
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Next to their role in IgE-mediated allergic diseases and in promoting inflammation, mast cells also have antiinflammatory functions. They release pro- as well as antiinflammatory mediators, depending on the biological setting. Here we aimed to better
Externí odkaz:
https://doaj.org/article/7e735f31a36b485bbd14ab87216dc27f
Autor:
Anja Kolbinger, Roxane Isabelle Kestner, Lara Jencio, Tim J. Schäufele, Rajkumar Vutukuri, Waltraud Pfeilschifter, Klaus Scholich
Publikováno v:
Cells, Vol 11, Iss 10, p 1659 (2022)
Ischemic stroke is a highly prevalent vascular disease leading to oxygen- and glucose deprivation in the brain. In response, ischemia-induced neovascularization occurs, which is supported by circulating CD34+ endothelial progenitor cells. Here, we us
Externí odkaz:
https://doaj.org/article/d9b76aac04d74f5c96fa730ea711b873
Autor:
Khadija El-Hindi, Sebastian Brachtendorf, Jennifer Christina Hartel, Stephanie Oertel, Kerstin Birod, Nadine Merz, Sandra Trautmann, Dominique Thomas, Andreas Weigert, Tim J. Schäufele, Klaus Scholich, Susanne Schiffmann, Thomas Ulshöfer, Olaf Utermöhlen, Sabine Grösch
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1866 (2022)
To better understand the role of sphingolipids in the multifactorial process of inflammatory bowel disease (IBD), we elucidated the role of CerS4 in colitis and colitis-associated cancer (CAC). For this, we utilized the azoxymethane/dextran sodium su
Externí odkaz:
https://doaj.org/article/2c76c4616cab4587889088684d7b1b45
Autor:
Sorin Tunaru, Remy Bonnavion, Isabell Brandenburger, Jens Preussner, Dominique Thomas, Klaus Scholich, Stefan Offermanns
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
FFAR1 receptor is highly expressed in beta cells and its activation has been suggested as therapy against type-2 diabetes. Here, Tunaru et al. show that 20-hydroxyeicosatetraenoic acid, produced within the islets upon glucose stimulation, acts in an
Externí odkaz:
https://doaj.org/article/9a7ee26cbe794bc5b4667eb9d97b5e93