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Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is frequently detected in late stages, which leads to limited therapeutic options and a dismal overall survival rate. To date, no robust method for the detection of early-stage PDAC that can be used fo
Externí odkaz:
https://doaj.org/article/b8847a40687f44c1b4bcf77ba0ffe9bd
Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma
Autor:
Mark Sementsov, Leonie Ott, Julian Kött, Alexander Sartori, Amelie Lusque, Sarah Degenhardt, Bertille Segier, Isabel Heidrich, Beate Volkmer, Rüdiger Greinert, Peter Mohr, Ronald Simon, Julia-Christina Stadler, Darryl Irwin, Claudia Koch, Antje Andreas, Benjamin Deitert, Verena Thewes, Andreas Trumpp, Andreas Schneeweiss, Yassine Belloum, Sven Peine, Harriett Wikman, Sabine Riethdorf, Stefan W Schneider, Christoffer Gebhardt, Klaus Pantel, Laura Keller
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1560-1578 (2024)
Abstract Circulating tumor DNA (ctDNA) is the cornerstone of liquid biopsy diagnostics, revealing clinically relevant genomic aberrations from blood of cancer patients. Genomic analysis of single circulating tumor cells (CTCs) could provide additiona
Externí odkaz:
https://doaj.org/article/4b6305c88a944631907935568207306e
Autor:
Nishit Goradia, Stefan Werner, Edukondalu Mullapudi, Sarah Greimeier, Lina Bergmann, Andras Lang, Haydyn Mertens, Aleksandra Węglarz, Simon Sander, Grzegorz Chojnowski, Harriet Wikman, Oliver Ohlenschläger, Gunhild von Amsberg, Klaus Pantel, Matthias Wilmanns
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract While the elucidation of regulatory mechanisms of folded proteins is facilitated due to their amenability to high-resolution structural characterization, investigation of these mechanisms in disordered proteins is more challenging due to the
Externí odkaz:
https://doaj.org/article/5074a5174b144e20817298b0df93967f
Autor:
Daniel J. Smit, Konstantin Hoffer, Bettina Bettin, Malte Kriegs, Laure Cayrefourcq, Udo Schumacher, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker
Publikováno v:
Cancer Medicine, Vol 13, Iss 20, Pp n/a-n/a (2024)
ABSTRACT Background Research on circulating tumor cells (CTCs) offers the opportunity to better understand the initial steps of blood‐borne metastasis as main cause of cancer‐related deaths. Here, we have used the colon cancer CTC‐MCC‐41 and
Externí odkaz:
https://doaj.org/article/01c855f9ce71411bbeb5e216d4700d46
Autor:
Lisa-Marie Rieckmann, Michael Spohn, Lisa Ruff, David Agorku, Lisa Becker, Alina Borchers, Jenny Krause, Roisin O’Reilly, Jurek Hille, Janna-Lisa Velthaus-Rusik, Niklas Beumer, Armin Günther, Lena Willnow, Charles D. Imbusch, Peter Iglauer, Ronald Simon, Sören Franzenburg, Hauke Winter, Michael Thomas, Carsten Bokemeyer, Nicola Gagliani, Christian F. Krebs, Martin Sprick, Olaf Hardt, Sabine Riethdorf, Andreas Trumpp, Nikolas H. Stoecklein, Sven Peine, Philipp Rosenstiel, Klaus Pantel, Sonja Loges, Melanie Janning
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background Circulating tumor cells (CTCs) hold immense promise for unraveling tumor heterogeneity and understanding treatment resistance. However, conventional methods, especially in cancers like non-small cell lung cancer (NSCLC), often yie
Externí odkaz:
https://doaj.org/article/2c341ef7571b4502937a3beb26a74b4b
Autor:
Svenja Schneegans, Jana Löptien, Angelika Mojzisch, Desirée Loreth, Oliver Kretz, Christoph Raschdorf, Annkathrin Hanssen, Antonia Gocke, Bente Siebels, Karthikeyan Gunasekaran, Yi Ding, Leticia Oliveira-Ferrer, Laura Brylka, Thorsten Schinke, Hartmut Schlüter, Ilkka Paatero, Hannah Voß, Stefan Werner, Klaus Pantel, Harriet Wikman
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Metastasis is the leading cause of cancer-related death in non-small cell lung cancer (NSCLC) patients. We previously showed that low HERC5 expression predicts early tumor dissemination and a dismal prognosis in NSCLC patients. He
Externí odkaz:
https://doaj.org/article/8ee82af4958b47ecbef81f24542bd06c
Publikováno v:
Genetics and Molecular Biology, Vol 47, Iss 2 (2024)
Abstract Growth differentiation factor 11 (GDF11) and myostatin (MSTN/GDF8) are closely related members of the transforming growth factor β (TGFβ) superfamily, sharing structural homology. Despite these structural similarities, recent research has
Externí odkaz:
https://doaj.org/article/788ba200791344ccb4f46ea9ecc402a1
Autor:
Nicolas Hohmann, Martin Ronald Sprick, Moritz Pohl, Azaz Ahmed, Jürgen Burhenne, Marietta Kirchner, Lucian Le Cornet, Markus Kratzmann, Jacek Hajda, Albrecht Stenzinger, Karen Steindorf, Stefan Delorme, Heinz‐Peter Schlemmer, Sabine Riethdorf, Ron vanSchaik, Klaus Pantel, Jens Siveke, Thomas Seufferlein, Dirk Jäger, Walter E. Haefeli, Andreas Trumpp, Christoph Springfeld
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2483-2493 (2023)
Abstract Expression of CYP3A5 protein is a basal and acquired resistance mechanism of pancreatic ductal adenocarcinoma cells conferring protection against the CYP3A and CYP2C8 substrate paclitaxel through metabolic degradation. Inhibition of CYP3A is
Externí odkaz:
https://doaj.org/article/c68c01273a54478990c71f106d610b42
Autor:
Lorenz Kocheise, Martin Schoenlein, Berit Behrends, Vincent Joerg, Christian Casar, Thorben W. Fruendt, Thomas Renné, Asmus Heumann, Jun Li, Samuel Huber, Ansgar W. Lohse, Klaus Pantel, Sabine Riethdorf, Henning Wege, Kornelius Schulze, Johann von Felden
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Hepatocellular carcinoma (HCC) has high recurrence rates exceeding 50% despite curative resection. The serum biomarker alpha-fetoprotein (AFP) is a well-known prognostic marker for HCC. EpCAM-positive circulating tumor cells (CTC) have a hig
Externí odkaz:
https://doaj.org/article/15b7e984aa6d4635b4ab35ffa9783014