Zobrazeno 1 - 10
of 377
pro vyhledávání: '"Klaus, Mohr"'
Autor:
Matthias Irmen, Janine Holze, Michael Kauk, Marcel Bermudez, Marco De Amici, Clelia Dallanoce, Klaus Mohr, Theresa Bödefeld, Gabriele M. König, Andreas Bock, Eva Marie Pfeil, Carsten Hoffmann, Gerhard Wolber, Carlo Matera, Ulrike Holzgrabe, Evi Kostenis, Ramona Schrage, Christian Tränkle
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Allosteric coupling describes a reciprocal process whereby G-protein-coupled receptors (GPCRs) relay ligand-induced conformational changes from the extracellular binding pocket to the intracellular signaling surface. Therefore, GPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b5f203c7b3b178ef34fa4414d35cba
https://doi.org/10.1021/acsptsci.0c00069
https://doi.org/10.1021/acsptsci.0c00069
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 391:1295-1299
Muscarinic M2 and M4 receptors resemble each other in brain distribution, function, and Gi/o protein signaling. However, there is evidence from human recombinant receptors that the M4 receptor also couples to Gs protein whereas such an alternative si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::884b07ffb7e57cc7dfd5b533c5ef3fba
https://doi.org/10.1007/s00210-018-1539-8
https://doi.org/10.1007/s00210-018-1539-8
Autor:
Fabian Krebs, Klaus Mohr, Martin J. Lohse, Marcel Bermudez, Ulrike Holzgrabe, Andreas Bock, Gerhard Wolber
Publikováno v:
ACS Chemical Biology. 12:1743-1748
G protein-coupled receptors transmit extracellular signals across cell membranes via different G protein classes and β-arrestins. Some pathways may be therapeutically beneficial, whereas others may be detrimental under certain pathophysiological con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5fc539fe41573b8e799450272ea6211
https://doi.org/10.1021/acschembio.7b00275
https://doi.org/10.1021/acschembio.7b00275
Autor:
Klaus Mohr, Evi Kostenis, Mathias Muth, Ramona Schrage, Jessica Kloeckner, Janine Holze, Anna De Min, Carlo Matera, Ulrike Holzgrabe, Terry P. Kenakin, Clelia Dallanoce, Andreas Bock, Marco De Amici, Christian Traenkle
Publikováno v:
Molecular Pharmacology. 91:348-356
Protean agonists are of great pharmacological interest as their behavior may change in magnitude and direction depending on the constitutive activity of a receptor. Yet, this intriguing phenomenon has been poorly described and understood, due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a644b980d27e465166376ae3ab29feb
https://doi.org/10.1124/mol.116.107276
https://doi.org/10.1124/mol.116.107276
Autor:
Janine Holze, Dina Manetti, Christian Tränkle, Klaus Mohr, Elisabetta Teodori, Maria Vittoria Martino, Cristina Bellucci, Maria Novella Romanelli, Giulio Vistoli, Jessica Welzel, Silvia Dei, Angelica Mazzolari, Marta Nesi, Ulrike Bartz, Rosanna Matucci
Publikováno v:
European journal of pharmacology. 883
Although agonists and antagonists of muscarinic receptors have been known for long time, there is renewed interest in compounds (such as allosteric or bitopic ligands, or biased agonists) able to differently and selectively modulate these receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88ca14a4fbf7a1acd767dca1e4963fc
https://pubmed.ncbi.nlm.nih.gov/32534072
https://pubmed.ncbi.nlm.nih.gov/32534072
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 391(11)
Muscarinic M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c42882e0cc4422681608d650f0e0e1dc
https://pubmed.ncbi.nlm.nih.gov/30032313
https://pubmed.ncbi.nlm.nih.gov/30032313
Publikováno v:
British Journal of Pharmacology. 173:3018-3027
Ligands targeting GPCRs can be categorized according to their intrinsic efficacy to trigger a specific, receptor-mediated response. A ligand endowed with the same level of efficacy as the endogenous agonist can be classified as a full agonist, wherea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ab0cb27972c8eceaf3695e327f3c1e
https://doi.org/10.1111/bph.13278
https://doi.org/10.1111/bph.13278
Autor:
Evi Kostenis, Jesus Gomeza, Theresa Bödefeld, Anne-Gaelle Letombe, Michel Gillard, Ramona Schrage, Qing Richard Lu, Liguo Zhang, Julia Fischer, Nicole Merten, Klaus Mohr, Ralf Schröder, Katharina Simon, Celine Vermeiren, Oliver Brüstle, Lucas Peters, Stephanie Hennen
Publikováno v:
Cell chemical biology. 25(6)
Identification of additional uses for existing drugs is a hot topic in drug discovery and a viable alternative to de novo drug development. HAMI3379 is known as an antagonist of the cysteinyl-leukotriene CysLT(2) receptor, and was initially developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1c8d719c8ff159b38452208b5164c2
https://pubmed.ncbi.nlm.nih.gov/29706593
https://pubmed.ncbi.nlm.nih.gov/29706593
Autor:
Marcel, Bermudez, Andreas, Bock, Fabian, Krebs, Ulrike, Holzgrabe, Klaus, Mohr, Martin J, Lohse, Gerhard, Wolber
Publikováno v:
ACS chemical biology. 12(7)
G protein-coupled receptors transmit extracellular signals across cell membranes via different G protein classes and β-arrestins. Some pathways may be therapeutically beneficial, whereas others may be detrimental under certain pathophysiological con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12f062d97b537fb29eedd5b4e5e01890
https://pubmed.ncbi.nlm.nih.gov/28585805
https://pubmed.ncbi.nlm.nih.gov/28585805
Autor:
Klaus Mohr, Marcel Bermudez, Ramona Schrage, Ulrike Holzgrabe, Jens Schmitz, Gerhard Wolber, Dorina van der Mey, Christian Tränkle, Evi Kostenis, Jessica Klöckner
Publikováno v:
Journal of Medicinal Chemistry. 57:6739-6750
Bivalent ligands of G protein-coupled receptors have been shown to simultaneously either bind to two adjacent receptors or to bridge different parts of one receptor protein. Recently, we found that bivalent agonists of muscarinic receptors can simult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c3618c63bc35f9c5ebcb90b97f9856
https://doi.org/10.1021/jm500790x
https://doi.org/10.1021/jm500790x