Zobrazeno 1 - 10
of 504
pro vyhledávání: '"Klaus, Klaushofer"'
Autor:
Cheng-Chia Tang, Christian D Castro Andrade, Maureen J O'Meara, Sung-Hee Yoon, Tadatoshi Sato, Daniel J Brooks, Mary L Bouxsein, Janaina da Silva Martins, Jinhua Wang, Nathanael S Gray, Barbara Misof, Paul Roschger, Stephane Blouin, Klaus Klaushofer, Annegreet Velduis-Vlug, Yosta Vegting, Clifford J Rosen, Daniel O'Connell, Thomas B Sundberg, Ramnik J Xavier, Peter Ung, Avner Schlessinger, Henry M Kronenberg, Rebecca Berdeaux, Marc Foretz, Marc N Wein
Publikováno v:
eLife, Vol 10 (2021)
Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05–099 potently inhibits salt inducible kinases (SIKs) and may repres
Externí odkaz:
https://doaj.org/article/df0d71f913fb4c5a97707f2fd4b38a59
Autor:
Gali Guterman-Ram, Ghazal Hedjazi, Chris Stephan, Stéphane Blouin, Paul Roschger, Klaus Klaushofer, Jochen Zwerina, Kenneth M. Kozloff, Nadja Fratzl-Zelman, Joan C. Marini
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100650- (2020)
Externí odkaz:
https://doaj.org/article/e86fe0bcedb1451fae44b9cee29bd749
Autor:
Barbara M. Misof, Paul Roschger, Hua Zhou, Jeri W. Nieves, Mathias Bostrom, Felicia Cosman, Robert Lindsay, Klaus Klaushofer, David W. Dempster
Publikováno v:
Bone Reports, Vol 12, Iss , Pp 100253- (2020)
The influence of treatment with alendronate (ALN), teriparatide (TPTD) or concurrent treatment with both on the human bone matrix mineralization has not yet been fully elucidated. For this purpose we analyzed quadruple fluorochrome labelled transilia
Externí odkaz:
https://doaj.org/article/12da4b5886e64aa1ace6afbbd8769409
Autor:
Suma Uday, Nadja Fratzl-Zelman, Paul Roschger, Klaus Klaushofer, Ashish Chikermane, Vrinda Saraff, Ted Tulchinsky, Tom D. Thacher, Tamas Marton, Wolfgang Högler
Publikováno v:
BMC Pediatrics, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Whilst hypocalcemic complications from vitamin D deficiency are considered rare in high-income countries, they are highly prevalent among Black, Asian and Minority Ethnic (BAME) group with darker skin. To date, the extent of osteo
Externí odkaz:
https://doaj.org/article/ad9d699364e9440e99ddaad08e776384
Autor:
Heeseog Kang, Smita Jha, Zuoming Deng, Nadja Fratzl-Zelman, Wayne A. Cabral, Aleksandra Ivovic, Françoise Meylan, Eric P. Hanson, Eileen Lange, James Katz, Paul Roschger, Klaus Klaushofer, Edward W. Cowen, Richard M. Siegel, Joan C. Marini, Timothy Bhattacharyya
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Melorheostosis is characterized by bone overgrowth and associated with pain and functional impairment. Here, the authors use whole exome sequencing to identify somatic mutations in MAP2K1 in affected bone of melorheostosis patients which is associate
Externí odkaz:
https://doaj.org/article/09b0dd3aa7ac4ad59c6710da313a7a43
Autor:
Maziar Shabestari, Erik Fink Eriksen, Eleftherios P. Paschalis, Paul Roschger, Sonja Gamsjaeger, Klaus Klaushofer, Andrea Berzlanovich, Xavier Nogues, Lluis Puig, Adolfo Diez-Perez
Publikováno v:
Bone Reports, Vol 6, Iss C, Pp 81-86 (2017)
Long-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In the present case report we present the results of analysis of bone chips from a 74-year o
Externí odkaz:
https://doaj.org/article/e0ee5c5c98f84f1ebf061853358c9c68
Autor:
Barbara M. Misof, Paul Roschger, Charles Chen, Maureen Pickarski, Phaedra Messmer, Klaus Klaushofer, Le T. Duong
Publikováno v:
Bone Reports, Vol 5, Iss , Pp 62-69 (2016)
Odanacatib (ODN) is a selective and reversible inhibitor of cathepsin K which is an important enzyme for the degradation of collagen I. Aim of the present work was the head-to-head comparison between the effects of ODN and alendronate (ALN) on bone m
Externí odkaz:
https://doaj.org/article/00b5e204419c42a4b586d6915559e1d2
Autor:
Jochen G Hofstaetter, Barbara M Misof, Dallas C Jones, Ruth Zoehrer, Stéphane Blouin, Christiane Schueler, Eleftherios P Paschalis, Reinhold G Erben, Richard Weinkamer, Klaus Klaushofer, Paul Roschger
Publikováno v:
JBMR Plus, Vol 3, Iss 11, Pp n/a-n/a (2019)
ABSTRACT Schnurri‐3 (Shn3) is an essential regulator of postnatal skeletal remodeling. Shn3‐deficient mice (Shn3–/–) have high bone mass; however, their bone mechanical and material properties have not been investigated to date. We performed
Externí odkaz:
https://doaj.org/article/beceafcfc65d4d64a7f762c5fcb54b09
Publikováno v:
F1000Research, Vol 8 (2019)
The main clinical tool for the diagnosis and treatment of skeletal diseases such as osteoporosis is the determination of bone mineral density by dual x-ray absorptiometry. Although this outcome contributes to the determination of bone strength, the c
Externí odkaz:
https://doaj.org/article/6e1ad6b71c1743dab4bea09d5703111d
Autor:
Wolfgang Brozek, Berthold Reichardt, Jochen Zwerina, Hans Peter Dimai, Klaus Klaushofer, Elisabeth Zwettler
Publikováno v:
Bone Reports, Vol 10, Iss , Pp - (2019)
Aim: To examine the association of proton pump inhibitor (PPI) use with subsequent hip fracture incidence in hip fracture patients, accounting for gender, age, PPI doses, PPI initiation before or after first fracture, and year from first fracture in
Externí odkaz:
https://doaj.org/article/5873f3d560d7421db6bae1aa48080863