Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Klaus, Groschner"'
Autor:
Amy Clarke, Julia Skerjanz, Mathias A. F. Gsell, Patrick Wiedner, Hazel Erkan-Candag, Klaus Groschner, Thomas Stockner, Oleksandra Tiapko
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The transient receptor potential canonical type 3 (TRPC3) channel plays a pivotal role in regulating neuronal excitability in the brain via its constitutive activity. The channel is intricately regulated by lipids and has previously been dem
Externí odkaz:
https://doaj.org/article/de6a853f0fa045d0a376f178fdcb572b
Autor:
Christina Humer, Tamara Radiskovic, Kata Horváti, Sonja Lindinger, Klaus Groschner, Christoph Romanin, Carmen Höglinger
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 618 (2024)
The epithelial ion channel TRPV6 plays a pivotal role in calcium homeostasis. Channel function is intricately regulated at different stages, involving the lipid phosphatidylinositol-4,5-bisphosphate (PIP2). Given that dysregulation of TRPV6 is associ
Externí odkaz:
https://doaj.org/article/c30678cd72bc4e5899e2281a57c2bd48
Autor:
Gaëlle Rached, Youakim Saliba, Dina Maddah, Joelle Hajal, Viviane Smayra, Jules‐Joel Bakhos, Klaus Groschner, Lutz Birnbaumer, Nassim Fares
Publikováno v:
Advanced Science, Vol 10, Iss 6, Pp n/a-n/a (2023)
Abstract Insulin release is tightly controlled by glucose‐stimulated calcium (GSCa) through hitherto equivocal pathways. This study investigates TRPC3, a non‐selective cation channel, as a critical regulator of insulin secretion and glucose contr
Externí odkaz:
https://doaj.org/article/d2562867f7e34aa88d88b57525e7fc05
Publikováno v:
Metabolism Open, Vol 15, Iss , Pp 100206- (2022)
Background: The prevalence of obesity is higher in Western countries than in East Asian countries. It remains unknown whether microRNAs (miRNAs) are involved in the pathogenesis of the ethnic difference in obesity. The purpose of this study was to de
Externí odkaz:
https://doaj.org/article/8232df69b4bb4d01981276056da3f2c8
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 890 (2022)
Transient receptor potential canonical 3 (TRPC3) channel belongs to the superfamily of transient receptor potential (TRP) channels which mediate Ca2+ influx into the cell. These channels constitute essential elements of cellular signalling and have b
Externí odkaz:
https://doaj.org/article/c64650d724144ba88d7914d1b2250e8d
Autor:
Hazel Erkan-Candag, Denis Krivic, Mathias A. F. Gsell, Mina Aleksanyan, Thomas Stockner, Rumiana Dimova, Oleksandra Tiapko, Klaus Groschner
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 799 (2022)
Azobenzene-based photochromic lipids are valuable probes for the analysis of ion channel–lipid interactions. Rapid photoisomerization of these molecules enables the analysis of lipid gating kinetics and provides information on lipid sensing. Therma
Externí odkaz:
https://doaj.org/article/95339a7f22194a6886b802bc99783e5c
Autor:
Helmut Bischof, Sandra Burgstaller, Anna Springer, Lucas Matt, Thomas Rauter, Olaf A. Bachkönig, Tony Schmidt, Klaus Groschner, Rainer Schindl, Tobias Madl, Nikolaus Plesnila, Robert Lukowski, Wolfgang F. Graier, Roland Malli
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102468- (2021)
Externí odkaz:
https://doaj.org/article/aa5c9905364c4c30bea6ea7a049a7987
Autor:
Bernadett Bacsa, Annarita Graziani, Denis Krivic, Patrick Wiedner, Roland Malli, Thomas Rauter, Oleksandra Tiapko, Klaus Groschner
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca2+ handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses. Utilizing
Externí odkaz:
https://doaj.org/article/221a4a492cf645c7af96cfa02cdbacfe
Autor:
Niroj Shrestha, Bernadett Bacsa, Hwei Ling Ong, Susanne Scheruebel, Helmut Bischof, Roland Malli, Indu Suresh Ambudkar, Klaus Groschner
Publikováno v:
PLoS Biology, Vol 18, Iss 4, p e3000700 (2020)
Trimeric intracellular cation (TRIC) channels have been proposed to modulate Ca2+ release from the endoplasmic reticulum (ER) and determine oscillatory Ca2+ signals. Here, we report that TRIC-A-mediated amplitude and frequency modulation of ryanodine
Externí odkaz:
https://doaj.org/article/c56f5c800b114eb09cbf5150a7c65b5e
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 850 (2022)
Nano-junctions between the endoplasmic reticulum and cytoplasmic surfaces of the plasma membrane and other organelles shape the spatiotemporal features of biological Ca2+ signals. Herein, we propose that 2D Ca2+ exchange diffusion on the negatively c
Externí odkaz:
https://doaj.org/article/568800ba62f9475c8b46475861947d10