Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Klaus, Gawrisch"'
Autor:
Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, Clemens Glaubitz
Publikováno v:
ACS Omega, Vol 8, Iss 36, Pp 32963-32976 (2023)
Externí odkaz:
https://doaj.org/article/543ddeac6e3345cbaafa6a8240ec5d13
Autor:
Alexei Yeliseev, Malliga R. Iyer, Thomas T. Joseph, Nathan J. Coffey, Resat Cinar, Lioudmila Zoubak, George Kunos, Klaus Gawrisch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases b
Externí odkaz:
https://doaj.org/article/f7405dfa40aa4301afa918bbd3f3c38d
Autor:
An Ghysels, Andreas Krämer, Richard M. Venable, Walter E. Teague, Edward Lyman, Klaus Gawrisch, Richard W. Pastor
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Increasing evidence supports the existence of ordered nanodomains (or rafts) in cholesterol rich cell membranes. Here authors present molecular dynamics simulations and EPR experiments to monitor permeation of oxygen and water through membranes in th
Externí odkaz:
https://doaj.org/article/e91db752ad0d4f168ae8b7aecf6084be
Publikováno v:
Biophysical Journal. 122:973-983
We monitored the effect on function of the G-protein-coupled receptor (GPCR) rhodopsin from small, stepwise changes in bilayer thickness induced by cholesterol. Over a range of phosphatidylcholine bilayers with hydrophobic thickness from ≈21 Å to
Publikováno v:
Journal of Biological Chemistry. 295:181-190
G protein–coupled receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of a broad spectrum of physiological processes and are a major target for pharmaceutical drug development. Structural studies can he
Autor:
Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Claudia Korn, David Sykes, Gabriel Forn-Cuni, Patrick Pfaff, Roman C. Sarott, Matthias V. Westphal, Yelena Mostinski, Leonard Mach, Malgorzata Wasinska-Kalwa, Marie Weise, Bradley L. Hoare, Tamara Miljuš, Maira Mexi, Nicolas Roth, Eline J. Koers, Wolfgang Guba, André Alker, Arne C. Rufer, Eric A. Kusznir, Sylwia Huber, Catarina Raposo, Elisabeth A. Zirwes, Anja Osterwald, Anto Pavlovic, Svenja Moes, Jennifer Beck, Matthias Nettekoven, Irene Benito-Cuesta, Teresa Grande, Faye Drawnel, Gabriella Widmer, Daniela Holzer, Tom van der Wel, Harpreet Mandhair, Michael Honer, Jürgen Fingerle, Jörg Scheffel, Johannes Broichhagen, Klaus Gawrisch, Julián Romero, Cecilia J. Hillard, Zoltan V. Varga, Mario van der Stelt, Pal Pacher, Jürg Gertsch, Christoph Ullmer, Peter J. McCormick, Sergio Oddi, Herman P. Spaink, Mauro Maccarrone, Dmitry B. Veprintsev, Erick M. Carreira, Uwe Grether, Marc Nazaré
Publikováno v:
Gazzi, Thais; Brennecke, Benjamin; Atz, Kenneth; Korn, Claudia; Sykes, David; Forn-Cuni, Gabriel; Pfaff, Patrick; Sarott, Roman C; Westphal, Matthias V; Mostinski, Yelena; Mach, Leonard; Wasinska-Kalwa, Malgorzata; Weise, Marie; Hoare, Bradley L; Miljuš, Tamara; Mexi, Maira; Roth, Nicolas; Koers, Eline J; Guba, Wolfgang; Alker, André; ... (2022). Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe. Chemical Science, 13(19), pp. 5539-5545. The Royal Society of Chemistry 10.1039/d1sc06659e
Chemical Science, 13(19), 5539-5545
Chemical Science
Chemical Science, 13(19), 5539-5545
Chemical Science
Despite its essential role in the (patho)physiology of several diseases, CB2R tissue expression profiles and signaling mechanisms are not yet fully understood. We report the development of a highly potent, fluorescent CB2R agonist probe employing str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e61ac61b6e5b29da1ceeb545f2c056
http://hdl.handle.net/11697/192023
http://hdl.handle.net/11697/192023
Autor:
George Kunos, Thomas T. Joseph, Resat Cinar, Klaus Gawrisch, Nathan J. Coffey, Lioudmila Zoubak, Alexei Yeliseev, Malliga R. Iyer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases basal acti
Site-selective labeling and electron paramagnetic resonance studies of human cannabinoid receptor CB
Autor:
Alexei A, Yeliseev, Kaeli, Zoretich, Levi, Hooper, Walter, Teague, Lioudmila, Zoubak, Kirk G, Hines, Klaus, Gawrisch
Publikováno v:
Biochim Biophys Acta Biomembr
Integral membrane G protein-coupled receptors (GPCR) regulate multiple physiological processes by transmitting signals from extracellular milieu to intracellular proteins and are major targets of pharmaceutical drug development. Since GPCR are inhere
Autor:
Alexei Yeliseev, Kaeli Zoretich, Levi Hooper, Walter E. Teague, Lioudmila Zoubak, Kirk G. Hines, Klaus Gawrisch
Publikováno v:
Biophysical Journal. 121:85a
Autor:
Kyle Williston, Alexei Yeliseev, Arjen van den Berg, Lioudmila Zoubak, Wanhua Yan, Sam Stepnowski, Jonathan Zmuda, Kirk G. Hines, Klaus Gawrisch
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Rational design of pharmaceutical drugs targeting integral membrane G protein-coupled receptors (GPCR) requires thorough understanding of ligand binding and mechanism of activation through high resolution structural studies of purified proteins. Due