Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Klaus, Früh"'
Autor:
Daniel Malouli, Meenakshi Tiwary, Roxanne M. Gilbride, David W. Morrow, Colette M. Hughes, Andrea Selseth, Toni Penney, Priscila Castanha, Megan Wallace, Yulia Yeung, Morgan Midgett, Connor Williams, Jason Reed, Yun Yu, Lina Gao, Gabin Yun, Luke Treaster, Amanda Laughlin, Jeneveve Lundy, Jennifer Tisoncik-Go, Leanne S. Whitmore, Pyone P. Aye, Faith Schiro, Jason P. Dufour, Courtney R. Papen, Husam Taher, Louis J. Picker, Klaus Früh, Michael Gale, Nicholas J. Maness, Scott G. Hansen, Simon Barratt-Boyes, Douglas S. Reed, Jonah B. Sacha
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract An influenza vaccine approach that overcomes the problem of viral sequence diversity and provides long-lived heterosubtypic protection is urgently needed to protect against pandemic influenza viruses. Here, to determine if lung-resident effe
Externí odkaz:
https://doaj.org/article/30aee6ee13914e60b17c02c57c123179
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The commonly used antibodies 3D12 and 4D12 recognise the human leukocyte antigen E (HLA-E) protein. These antibodies bind distinct epitopes on HLA-E and differ in their ability to bind alleles of the major histocompatibility complex E (MHC-E) protein
Externí odkaz:
https://doaj.org/article/fdfd46d1a98a4b46a94c1f7c13ac7742
Autor:
Claire E Otero, Richard Barfield, Elizabeth Scheef, Cody S Nelson, Nicole Rodgers, Hsuan-Yuan Wang, Matilda J Moström, Tabitha D Manuel, Julian Sass, Kimberli Schmidt, Husam Taher, Courtney Papen, Lesli Sprehe, Savannah Kendall, Angel Davalos, Peter A Barry, Klaus Früh, Justin Pollara, Daniel Malouli, Cliburn Chan, Amitinder Kaur, Sallie R Permar
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011378 (2023)
Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV infection during pregnancy leads to a higher frequency of congenital CMV (cCMV) than maternal re-infection, suggesting that maternal immun
Externí odkaz:
https://doaj.org/article/c5d4db2c414e4452a4d70b4bd935fc85
Autor:
Matilda J Moström, Shan Yu, Dollnovan Tran, Frances M Saccoccio, Cyril J Versoza, Daniel Malouli, Anne Mirza, Sarah Valencia, Margaret Gilbert, Robert V Blair, Scott Hansen, Peter Barry, Klaus Früh, Jeffrey D Jensen, Susanne P Pfeifer, Timothy F Kowalik, Sallie R Permar, Amitinder Kaur
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011646 (2023)
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neurologic defects in newborns with particularly severe sequelae in the setting of primary CMV infection in the first trimester of pregnancy. The majority of cCMV cases worldwide oc
Externí odkaz:
https://doaj.org/article/1f4052f269cf4439b401b378a9c37424
Autor:
Jake C. Harbour, Mahmoud Abdelbary, John B. Schell, Samantha P. Fancher, Jack J. McLean, Taylen J. Nappi, Susan Liu, Timothy J. Nice, Zheng Xia, Klaus Früh, Jeffrey C. Nolz
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112407- (2023)
Summary: Poxvirus infections of the skin are a recent emerging public health concern, yet the mechanisms that mediate protective immunity against these viral infections remain largely unknown. Here, we show that T helper 1 (Th1) memory CD4+ T cells a
Externí odkaz:
https://doaj.org/article/6e4c0481da4d4781a64b5fe1b2ada48a
Autor:
Scott G. Hansen, Jennie L. Womack, Wilma Perez, Kimberli A. Schmidt, Emily Marshall, Ravi F. Iyer, Hillary Cleveland Rubeor, Claire E. Otero, Husam Taher, Nathan H. Vande Burgt, Richard Barfield, Kurt T. Randall, David Morrow, Colette M. Hughes, Andrea N. Selseth, Roxanne M. Gilbride, Julia C. Ford, Patrizia Caposio, Alice F. Tarantal, Cliburn Chan, Daniel Malouli, Peter A. Barry, Sallie R. Permar, Louis J. Picker, Klaus Früh
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Rhesus cytomegalovirus–based (RhCMV-based) vaccine vectors induce immune responses that protect ~60% of rhesus macaques (RMs) from SIVmac239 challenge. This efficacy depends on induction of effector memory–based (EM-biased) CD8+ T cells recognizi
Externí odkaz:
https://doaj.org/article/2cef4c4bc58642d4a61f2fb76b14a405
Autor:
Ravi F Iyer, David M Edwards, Philipp Kolb, Hans-Peter Raué, Chris A Nelson, Megan L Epperson, Mark K Slifka, Jeffrey C Nolz, Hartmut Hengel, Daved H Fremont, Klaus Früh
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010783 (2022)
The genome of cowpoxvirus (CPXV) could be considered prototypical for orthopoxviridae (OXPV) since it contains many open reading frames (ORFs) absent or lost in other OPXV, including vaccinia virus (VACV). These additional ORFs are non-essential for
Externí odkaz:
https://doaj.org/article/e93fab86cb334618aa4ef512794423a5
Autor:
Elham Beyranvand Nejad, Robert B. Ratts, Eleni Panagioti, Christine Meyer, Jennifer D. Oduro, Luka Cicin-Sain, Klaus Früh, Sjoerd H. van der Burg, Ramon Arens
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background The capacity of cytomegalovirus (CMV) to elicit long-lasting strong T cell responses, and the ability to engineer the genome of this DNA virus positions CMV-based vaccine vectors highly suitable as a cancer vaccine platform. Defin
Externí odkaz:
https://doaj.org/article/9a0739e7a5214c78a3304101c5cb7652
Publikováno v:
Trends in Immunology. 44:287-304
Autor:
Husam Taher, Eisa Mahyari, Craig Kreklywich, Luke S Uebelhoer, Matthew R McArdle, Matilda J Moström, Amruta Bhusari, Michael Nekorchuk, Xiaofei E, Travis Whitmer, Elizabeth A Scheef, Lesli M Sprehe, Dawn L Roberts, Colette M Hughes, Kerianne A Jackson, Andrea N Selseth, Abigail B Ventura, Hillary C Cleveland-Rubeor, Yujuan Yue, Kimberli A Schmidt, Jason Shao, Paul T Edlefsen, Jeremy Smedley, Timothy F Kowalik, Richard J Stanton, Michael K Axthelm, Jacob D Estes, Scott G Hansen, Amitinder Kaur, Peter A Barry, Benjamin N Bimber, Louis J Picker, Daniel N Streblow, Klaus Früh, Daniel Malouli
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008666 (2020)
Cytomegaloviruses (CMVs) are highly adapted to their host species resulting in strict species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal models using host-specific CMVs. Infection of rhesus macaques (RM) with
Externí odkaz:
https://doaj.org/article/18b74986983c43189be2f692f0340704