Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Klaus, Fechner"'
Autor:
Eberhard Krause, Klaus Fechner, Norbert Wendt, Sven Rothemund, Bienert M, Rainer Rudolph, Michael Beyermann, Jana Klose
Publikováno v:
Biochemistry. 44:1614-1623
The large extracellular N-terminal domains (NTs) of class B G protein-coupled receptors serve as major ligand binding sites. However, little is known about the ligand requirements for interactions with these receptor domains. Recently, we have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37844a4a3151fe7aba49a52360217bb0
https://doi.org/10.1021/bi049022e
https://doi.org/10.1021/bi049022e
Autor:
Reiner F. Haseloff, Valery V. Khramtsov, Katharina Mertsch, Ingolf E. Blasig, Dmitrii G. Mazhukin, Igor A. Kirilyuk, Klaus Fechner, Darkhan Utepbergenov
Publikováno v:
Journal of Medicinal Chemistry. 41:1027-1033
In this work we studied the mechanism of nitric oxide (NO) release underlying the vasorelaxant and antiaggregant effect of 3,4-dihydrodiazete 1,2-dioxides (DD). Six derivatives were included in the investigations, namely, 3-bromo- and 3-chloro-3,4,4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3c0db5d3be543512985283212fedb7
https://doi.org/10.1021/jm960737s
https://doi.org/10.1021/jm960737s
Autor:
Nadja Heinrich, Ingo Baeger, Dorothea Lorenz, Klaus Fechner, Hartmut Berger, Nelya N. Samovilova, Erika Albrecht
Publikováno v:
Pharmacology Biochemistry and Behavior. 58:189-194
The highly potent and efficacious mu-opioid agonist fentanyl was SC infused into rats with submaximal analgesic doses (0-1.14 mumol/kg/day) continuously for 8 days, checked by the constant daily urinary recovery of intact drug (0.43 +/- 0.031% of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a5cd61073cc2ecbfc9985beaac0121
https://doi.org/10.1016/s0091-3057(96)00480-7
https://doi.org/10.1016/s0091-3057(96)00480-7
Autor:
Michael Bienert, Klaus Fechner, Elvira Rohde, Carl Denef, Jens Furkert, Michael Beyermann, Regina M. Richter, Michael J. Mulvany, Hartmut Berger
Publikováno v:
Biochemical Pharmacology. 52:829-833
The potencies of the corticotropin-releasing hormone (CRH) agonistic peptides oCRH, h/rCRH, frog sauvagine, and carp urotensin I and of the antagonistic peptide α-helical CRH9-41 were compared in 3 different in vitro assays: (a) receptor binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5e1a9bbb8b68b7dcf7968ab83de232
https://doi.org/10.1016/0006-2952(96)00300-0
https://doi.org/10.1016/0006-2952(96)00300-0
Publikováno v:
Journal of Medicinal Chemistry. 39:3324-3330
In order to determine which amino acid side chains of ovine corticotropin releasing factor (oCRF) are most sensitive to alterations with respect to receptor binding and activation, we synthesized a single-point replacement set by replacing each resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bc77fe62f24c0c4c68e974938d0b6b
https://doi.org/10.1021/jm960116z
https://doi.org/10.1021/jm960116z
Autor:
Michael, Beyermann, Nadja, Heinrich, Klaus, Fechner, Jens, Furkert, Wei, Zhang, Oliver, Kraetke, Michael, Bienert, Hartmut, Berger
Publikováno v:
Advances in experimental medicine and biology. 611
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0adf09f80af72b4eca7a3e145295bdc5
https://pubmed.ncbi.nlm.nih.gov/19400304
https://pubmed.ncbi.nlm.nih.gov/19400304
Autor:
Wei Zhang, Nadja Heinrich, Jens Furkert, Klaus Fechner, Oliver Kraetke, Michael Bienert, Hartmut Berger, Michael Beyermann
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387736563
Introduction Most of the pharmaceuticals today target at G protein-coupled receptors (GPCRs) [1] that transmit extracellular signals into cells. GPCRs are promiscuous, that means a single receptor can activate different signalling events, presumably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a58e57b6e1d9a80a1cbe2b745346c255
https://doi.org/10.1007/978-0-387-73657-0_237
https://doi.org/10.1007/978-0-387-73657-0_237
Publikováno v:
British Polymer Journal. 23:235-240
The ring-opening polymerization of D, L-dilactide and an equimolar dilactide-diglycolide mixture has been investigated. Conversion and molecular weight in the lactide bulk polymerization are determined not only by the kinetics of the primary ring-ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::612e843bfcc7e5cbc3f5fb5e8d2243d4
https://doi.org/10.1002/pi.4980230310
https://doi.org/10.1002/pi.4980230310
Autor:
Rainer Rudolph, Sybille Kubald, Sven Rothemund, Norbert Wendt, Michael Bienert, Eberhard Krause, Klaus Fechner, Jana Klose, Michael Beyermann
Publikováno v:
Protein science, 13(9): 2470–2475
The oxidative folding, particularly the arrangement of disulfide bonds of recombinant extracellular N-terminal domains of the corticotropin-releasing factor receptor type 2a bearing five cysteines (C2 to C6), was investigated. Depending on the positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c07aafe76e6949ba73d958e48a983e4
https://europepmc.org/articles/PMC2280012/
https://europepmc.org/articles/PMC2280012/
Autor:
Jens Furkert, Michael Bienert, Hartmut Berger, Michael Beyermann, Nadja Heinrich, Doreen Wietfeld, Klaus Fechner
Publikováno v:
The Journal of biological chemistry. 279(37)
The regulation of G protein activation by the rat corticotropin-releasing factor receptor type 1 (rCRFR1) in human embryonic kidney (HEK)293 (HEK-rCRFR1) cell membranes was studied. Corresponding to a high and low affinity ligand binding site, sauvag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eba3077f54dde5752c27caf0df2276d
https://pubmed.ncbi.nlm.nih.gov/15252011
https://pubmed.ncbi.nlm.nih.gov/15252011