Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Klaudia Szymonowicz"'
Autor:
Adam Krysztofiak, Klaudia Szymonowicz, Julian Hlouschek, Kexu Xiang, Christoph Waterkamp, Safa Larafa, Isabell Goetting, Silvia Vega-Rubin-de-Celis, Carsten Theiss, Veronika Matschke, Daniel Hoffmann, Verena Jendrossek, Johann Matschke
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103366- (2021)
Summary: Cancer bioenergetics fuel processes necessary to maintain viability and growth under stress conditions. We hypothesized that cancer metabolism supports the repair of radiation-induced DNA double-stranded breaks (DSBs). We combined the system
Externí odkaz:
https://doaj.org/article/f4f90a877f724fafa3cbfea6ae94db1b
Autor:
Alina V. Meyer, Diana Klein, Simone de Leve, Klaudia Szymonowicz, Martin Stuschke, Simon C. Robson, Verena Jendrossek, Florian Wirsdörfer
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The ectonucleoside triphosphate diphosphohydrolase (CD39)/5′ ectonuclotidase (CD73)-dependent purinergic pathway emerges as promising cancer target. Yet, except for own previous work revealing a pathogenic role of CD73 and adenosine in radiation-in
Externí odkaz:
https://doaj.org/article/3e15d38c01eb46b5b9b03b43bd699837
Autor:
Klaudia Szymonowicz, Adam Krysztofiak, Jansje van der Linden, Ajvar Kern, Simon Deycmar, Sebastian Oeck, Anthony Squire, Benjamin Koska, Julian Hlouschek, Melanie Vüllings, Christian Neander, Jens T. Siveke, Johann Matschke, Martin Pruschy, Beate Timmermann, Verena Jendrossek
Publikováno v:
Cells, Vol 9, Iss 4, p 889 (2020)
Technical improvements in clinical radiotherapy for maximizing cytotoxicity to the tumor while limiting negative impact on co-irradiated healthy tissues include the increasing use of particle therapy (e.g., proton therapy) worldwide. Yet potential di
Externí odkaz:
https://doaj.org/article/af29afe2eb6a475593fd2b949fb00dd8
Autor:
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Publikováno v:
Science Advances. 8
Exploiting cancer vulnerabilities is critical for the discovery of anticancer drugs. However, tumor suppressors cannot be directly targeted because of their loss of function. To uncover specific vulnerabilities for cells with deficiency in any given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a60a21acef826731b021406130925a3
https://doi.org/10.1126/sciadv.abm6638
https://doi.org/10.1126/sciadv.abm6638
Autor:
Carsten Theiss, Johann Matschke, Christoph Waterkamp, Veronika Matschke, Klaudia Szymonowicz, Julian Hlouschek, Silvia Vega-Rubin-de-Celis, Isabell Goetting, Safa Larafa, Daniel Hoffmann, Verena Jendrossek, Kexu Xiang, Adam Krysztofiak
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103366-(2021)
iScience, Vol 24, Iss 11, Pp 103366-(2021)
Summary Cancer bioenergetics fuel processes necessary to maintain viability and growth under stress conditions. We hypothesized that cancer metabolism supports the repair of radiation-induced DNA double-stranded breaks (DSBs). We combined the systema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4e97be442a548767b1239f037d157d
https://doi.org/10.1016/j.isci.2021.103366
https://doi.org/10.1016/j.isci.2021.103366
Autor:
Verena Jendrossek, Klaudia Szymonowicz, Julian Hlouschek, Christoph Waterkamp, Johann Matschke, Kexu Xiang, Adam Krysztofiak, Daniel Hoffmann
Publikováno v:
Cancer Research. 81:3065-3065
Flexibility and reprogramming of cancer metabolism supports cancer progression and therapy resistance. In previous work we described opportunities for overcoming environment-induced resistance to ionizing radiation (IR) by pharmacologic inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::005400c9d5c0cfaf31676bcca1100741
https://doi.org/10.1158/1538-7445.am2021-3065
https://doi.org/10.1158/1538-7445.am2021-3065
Publikováno v:
Cancers
Cancers, Vol 10, Iss 3, p 78 (2018)
Cancers, Vol 10, Iss 3, p 78 (2018)
Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt) are observed with high frequency during malignant transformation and cancer progression. Oncogenic gene mutations coding for the upstream regulators or Akt,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650091938df91dd6f75d00e80c483f3a
http://europepmc.org/articles/PMC5876653
http://europepmc.org/articles/PMC5876653
Autor:
Adam Krysztofiak, Verena Jendrossek, Klaudia Szymonowicz, Sebastian Oeck, George Iliakis, Jansje van der Linden
Publikováno v:
International Journal of Molecular Sciences
Volume 19
Issue 8
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2233 (2018)
Volume 19
Issue 8
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2233 (2018)
The survival kinase protein kinase B (Akt) participates in the regulation of essential subcellular processes, e.g., proliferation, growth, survival, and apoptosis, and has a documented role in promoting resistance against genotoxic stress including r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cd076228046dcfc14e127866c1c814
https://doi.org/10.3390/ijms19082233
https://doi.org/10.3390/ijms19082233