Výsledky vyhledávání - "Klaudia M Sikora"

Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic–Ischemic Encephalopathy

Autor: Geraldine B. Boylan, Caroline Ahearne, NM Denihan, Mikael Finder, Gerard Clarke, Marc Paul O'Sullivan, Deirdre M. Murray, Klaudia M Sikora, Boubou Hallberg

Publikováno v: Neuropediatrics. 52:261-267

Background Activin A protein and its receptor ACVR2B have been considered viable biomarkers for the diagnosis of hypoxic–ischemic encephalopathy (HIE). This study aimed to assess umbilical cord blood (UCB) levels of Activin A and Acvr2b messenger R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e50c2ef6d40c140feda96175c1e9f2
https://doi.org/10.1055/s-0041-1725012

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Validation of Raised Cord Blood Interleukin-16 in Perinatal Asphyxia and Neonatal Hypoxic-Ischaemic Encephalopathy in the BiHiVE2 Cohort

Autor: Marc Paul O'Sullivan, Boubou Hallberg, Geraldine B. Boylan, Klaudia M Sikora, Mikael Finder, Deirdre Twomey, Caroline Ahearne, Deirdre M. Murray

Publikováno v: Developmental Neuroscience. 40:271-277

The role of inflammation is an important factor in the progression of hypoxic-ischaemic encephalopathy (HIE). We have previously shown that interleukin-16 (IL-16) is increased in infants with moderate and severe HIE and relates to poor neurodevelopme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c764e309404d8cc40143593d2b524337
https://doi.org/10.1159/000491386

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PHLDA2 is an imprinted gene in cattle

Autor: S. M. Waters, A.C.O. Evans, Aurélie Comte, Patrick Lonergan, David A. Magee, E. W. Berkowicz, Charles Spillane, David E. MacHugh, Fiona Carter, Klaudia M Sikora

Publikováno v: Animal Genetics. 43:587-590

Genomic imprinting is an epigenetic non-Mendelian phenomenon found predominantly in placental mammals. Imprinted genes display differential expression in the offspring depending on whether the gene is maternally or paternally inherited. Currently, so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61243ebc89b62a26d3fc40a0d26c2c68
https://doi.org/10.1111/j.1365-2052.2011.02292.x

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Single nucleotide polymorphisms in the imprinted bovine insulin-like growth factor 2 receptor gene (IGF2R) are associated with body size traits in Irish Holstein-Friesian cattle

Autor: David A. Magee, Charles Spillane, Klaudia M Sikora, Ross D Evans, Michael P. Mullen, Dawn J. Howard, Donagh P. Berry, E. W. Berkowicz, David E. MacHugh

Publikováno v: Animal Genetics. 43:81-87

Summary The regulation of the bioavailability of insulin-like growth factors (IGFs) is critical for normal mammalian growth and development. The imprinted insulin-like growth factor 2 receptor gene (IGF2R) encodes a transmembrane protein receptor tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::271a7f78e0bc4f79d4be86bd4efdcde7
https://doi.org/10.1111/j.1365-2052.2011.02211.x

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A catalogue of validated single nucleotide polymorphisms in bovine orthologs of mammalian imprinted genes and associations with beef production traits

Autor: David E. MacHugh, Torres Sweeney, B. W. Wickham, David A. Kenny, Klaudia M Sikora, Donagh P. Berry, E. W. Berkowicz, Stephen D. E. Park, David A. Magee, Alan K. Kelly, Charles Spillane, Ross D Evans

Publikováno v: Animal, Vol 4, Iss 12, Pp 1958-1970 (2010)

peer-reviewed Genetic (or ‘genomic’) imprinting, a feature of approximately 100 mammalian genes, results in monoallelic expression from one of the two parentally inherited chromosomes. To date, most studies have been directed on imprinted genes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cd10fb648fa9231645efe1e7e2f078
https://doi.org/10.1017/s1751731110001163

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Single nucleotide polymorphisms at the imprinted bovine insulin-like growth factor 2 ( igf2) locus are associated with dairy performance in irish holstein-friesian cattle

Autor: E. W. Berkowicz, Ross D Evans, Dawn J. Howard, Donagh P. Berry, David A. Magee, David E. MacHugh, Klaudia M Sikora, Charles Spillane, Michael P. Mullen

The imprinted insulin-like growth factor 2 gene (IGF2) encodes a fetal mitogenic hormone protein (IGF-II) and has previously been shown to be associated with performance in dairy cattle. In this study we assessed genotype-phenotype associations betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4098f41c771ee519b043a411d7f7a3
http://hdl.handle.net/10379/10415

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Single nucleotide polymorphisms within the bovine dlk1-dio3 imprinted domain are associated with economically important production traits in cattle

Autor: David A. Magee, Charles Spillane, Michael P. Mullen, Ross D Evans, David E. MacHugh, Dawn J. Howard, E. W. Berkowicz, Donagh P. Berry, Klaudia M Sikora

Previous studies show that DNA sequence variation within the mammalian DLK1-DIO3 imprinted domain influences production traits in domestic livestock, most notably the ovine callipyge phenotype. We assessed genotype-phenotype associations between 7 si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a54f69cdce80aba3636adb156479b8
http://hdl.handle.net/10379/12576

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Dna sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in irish holstein-friesian cattle

Autor: Michael P. Mullen, David E. MacHugh, Ross D Evans, Klaudia M Sikora, David A. Magee, Charles Spillane, Dawn J. Howard, Donagh P. Berry, E. W. Berkowicz

Publikováno v: BMC Genetics
BMC Genetics, Vol 11, Iss 1, p 93 (2010)

Background Studies in mice and humans have shown that imprinted genes, whereby expression from one of the two parentally inherited alleles is attenuated or completely silenced, have a major effect on mammalian growth, metabolism and physiology. More

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7913ced69b8a0b68de550bd75e71469e
http://hdl.handle.net/10379/12577

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