Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Klaudia, Giehl"'
Autor:
Rebekka Geißert, Angela Lammert, Stefanie Wirth, Rabea Hönig, Dirk Lohfink, Monika Unger, Denis Pek, Konstantin Schlüter, Theresa Scheftschik, Daniel J. Smit, Manfred Jücker, Andre Menke, Klaudia Giehl
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in increased amounts of active Ras-GTP and subsequently a hyperactivation of effector proteins
Externí odkaz:
https://doaj.org/article/6ad39e31b6e94163a40b075a091f8050
Publikováno v:
International Journal for Numerical Methods in Biomedical Engineering. 39
The primary cause for cancer-related death is metastasis, and although this phenomenon is the hallmark of cancer, it remains poorly understood. Since studies on the underlying mechanisms are still demanding by experimental means prognostic tools base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be41e5f04bf9e56f0ea5f4defa4703c3
https://doi.org/10.1002/cnm.3679
https://doi.org/10.1002/cnm.3679
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9324, p 9324 (2021)
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9324, p 9324 (2021)
Neural crest (NC) cells are highly migratory cells that contribute to various vertebrate tissues, and whose migratory behaviors resemble cancer cell migration and invasion. Information exchange via dynamic NC cell–cell contact is one mechanism by w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba53dc5c74211b7627c756bb42cce85
http://europepmc.org/articles/PMC8431534
http://europepmc.org/articles/PMC8431534
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121589 (2015)
Morphological alterations of cells can lead to modulation of gene expression. An essential link is the MKL1-dependent activation of serum response factor (SRF), which translates changes in the ratio of G- and F-actin into mRNA transcription. SRF acti
Externí odkaz:
https://doaj.org/article/8fb70c186dd74f0cbf5ac52f95d795fe
Autor:
Laura Scharlibbe, Klaudia Giehl, Andre Menke, Dirk Lohfink, Julia R. Seiz, Hendrik Ungefroren, Johannes Klinke, Marisa Heipel
Publikováno v:
Biological Chemistry. 401:517-531
Rac1 is a ubiquitously expressed Rho GTPase and an important regulator of the actin cytoskeleton. Its splice variant Rac1b exhibits a 19-amino acid (aa) in-frame insertion and is predominantly active. Both proteins were described in tumorigenesis or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97c72b53abcfb2ae03bebbbdb198d6e
https://doi.org/10.1515/hsz-2019-0329
https://doi.org/10.1515/hsz-2019-0329
Autor:
Luca Giordano, Anika Nolte, Ilka Wittig, Oleg Pak, Fenja Knoepp, Kerstin Ramser, Joel Wahl, Maik Hϋttemann, Lawrence I. Grossman, Petr Pecina, Hossein A. Ghofrani, Werner Seeger, Norbert Weissmann, Klaudia Giehl, Natascha Sommer
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1863:148893
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04ea605753d7a9aa22eccc9ed4e94293
https://doi.org/10.1016/j.bbabio.2022.148893
https://doi.org/10.1016/j.bbabio.2022.148893
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2728, p 2728 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The annual meeting “Signal Transduction–Receptors, Mediators and Genes” of the Signal Transduction Society (STS) is an interdisciplinary conference open to all scientists sharing the common interest in elucidating the signalling pathways underl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320205ee8aca6034e2d2ca56aacd6b94
https://www.mdpi.com/1422-0067/21/8/2728
https://www.mdpi.com/1422-0067/21/8/2728
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4258
A Clostridioides difficile infection (CDI) is the most common nosocomial infection worldwide. The main virulence factors of pathogenic C. difficile are TcdA and TcdB, which inhibit small Rho-GTPases. The inhibition of small Rho-GTPases leads to the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5b6ca971e966f687cb2e2e587ac94f
https://doi.org/10.3390/ijms23084258
https://doi.org/10.3390/ijms23084258
Publikováno v:
International Journal of Molecular Sciences. 23:2015
The annual meeting “Signal Transduction—Receptors, Mediators and Genes” of the Signal Transduction Society (STS) is an interdisciplinary conference which is open to all scientists sharing a common interest in the elucidation of the signaling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1421f332511772293b8b9f5d850989ee
https://doi.org/10.3390/ijms23042015
https://doi.org/10.3390/ijms23042015
Autor:
Monika Malczyk, Nasim Alebrahimdehkordi, Mareike Gierhardt, Natascha Sommer, Christopher Sinkler, Akylbek Sydykov, Azadeh Esfandiary, Matthias Hecker, Siddhesh Aras, Fenja Knoepp, Ralf P. Brandes, Friedrich Grimminger, Oleg Pak, Norbert Weissmann, Susan Scheibe, Maik Hüttemann, Klaudia Giehl, Simone Kraut, Ralph T. Schermuly, Lawrence I. Grossman, Christine Veith, Hossein Ardeschir Ghofrani, Werner Seeger, Felix Jonas
Publikováno v:
Circulation Research. 121:424-438
Rationale: Acute pulmonary oxygen sensing is essential to avoid life-threatening hypoxemia via hypoxic pulmonary vasoconstriction (HPV) which matches perfusion to ventilation. Hypoxia-induced mitochondrial superoxide release has been suggested as a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f829ad6e4a557d66b10b9928b3364b5
https://doi.org/10.1161/circresaha.116.310482
https://doi.org/10.1161/circresaha.116.310482