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Akademický článek

Kinetics of T cell-activation molecules in response to Mycobacterium tuberculosis antigens

Autor: Antas Paulo RZ, Oliveira Eliane B, Milagres Alexandre S, Franken Kees C, Ottenhoff Tom HM, Klatser Paul, Sarno Euzenir N, Sampaio Elizabeth P

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 97, Iss 8, Pp 1097-1099 (2002)

The phenotypic features acquired subsequent to antigen-specific stimulation in vitro were evaluated by means of the kinetic expressions of CD69 and CD25 activation molecules on T lymphocytes and assayed by flow cytometry in response to PPD, Ag85B, an

Externí odkaz: https://doaj.org/article/04a175b3ade746deacbb9a883124772f

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Akademický článek

The realistic performance achievable with mycobacterial automated culture systems in high and low prevalence settings

Autor: Klatser Paul R, Anthony Richard M, van Kampen Sanne C

Publikováno v: BMC Infectious Diseases, Vol 10, Iss 1, p 93 (2010)

Abstract Background Diagnostic tests are generally used in situations with similar pre-test probability of disease to where they were developed. When these tests are applied in situations with very different pre-test probabilities of disease, it is i

Externí odkaz: https://doaj.org/article/9bbc8cabb6e04bde8ea389309df1a773

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Akademický článek

Cost-effectiveness analysis of PCR for the rapid diagnosis of pulmonary tuberculosis

Autor: Vater Claudia, Rossetti Maria LR, Ruffino-Netto Antonio, Sperhacke Rosa D, Scherer Luciene C, Klatser Paul, Kritski Afrânio L

Publikováno v: BMC Infectious Diseases, Vol 9, Iss 1, p 216 (2009)

Abstract Background Tuberculosis is one of the most prominent health problems in the world, causing 1.75 million deaths each year. Rapid clinical diagnosis is important in patients who have co-morbidities such as Human Immunodeficiency Virus (HIV) in

Externí odkaz: https://doaj.org/article/ee621e7e9ada4e9fa04bc94a65cb0afe

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Akademický článek

The role and performance of chest X-ray for the diagnosis of tuberculosis: A cost-effectiveness analysis in Nairobi, Kenya

Autor: van Cleeff MRA, Kivihya-Ndugga LE, Meme H, Odhiambo JA, Klatser PR

Publikováno v: BMC Infectious Diseases, Vol 5, Iss 1, p 111 (2005)

Abstract Background The objective of this study was to establish 1) the performance of chest X-ray (CXR) in all suspects of tuberculosis (TB), as well as smear-negative TB suspects and 2) to compare the cost-effectiveness of the routine diagnostic pa

Externí odkaz: https://doaj.org/article/fcfa89b2dad54786947e3bbd04fed248

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Akademický článek

Genetic, household and spatial clustering of leprosy on an island in Indonesia: a population-based study

Autor: Oskam Linda, Klatser Paul R, Kwenang Agnes, Hatta Mochammad, May Linda, Bakker Mirjam I, Houwing-Duistermaat Jeanine J

Publikováno v: BMC Medical Genetics, Vol 6, Iss 1, p 40 (2005)

Abstract Background It is generally accepted that genetic factors play a role in susceptibility to both leprosy per se and leprosy type, but only few studies have tempted to quantify this. Estimating the contribution of genetic factors to clustering

Externí odkaz: https://doaj.org/article/35fd92d7149f4a14a2dc5d57c2ae54cc

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Akademický článek

Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency

Autor: Oskam Linda, Brown Tim J, Bergval Indra L, Schuitema Anja RJ, Anthony Richard M, Klatser Paul R

Publikováno v: Annals of Clinical Microbiology and Antimicrobials, Vol 4, Iss 1, p 9 (2005)

Abstract Background Mutations in a small region of the rpoB gene are responsible for most rifamycin resistance in Mycobacterium tuberculosis. In this study we have sequentially generated resistant strains to first rifampicin and then rifabutin. Porti

Externí odkaz: https://doaj.org/article/6d29b73e492e4dd483d6ab220dea26c5

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