Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Klas Hatje"'
Autor:
Martin Kollmar, Tobias Welz, Aishwarya Ravi, Thomas Kaufmann, Noura Alzahofi, Klas Hatje, Asmahan Alghamdi, Jiyu Kim, Deborah A. Briggs, Annette Samol-Wolf, Olena Pylypenko, Alistair N. Hume, Pawel Burkhardt, Jan Faix, Eugen Kerkhoff
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-21 (2024)
Abstract An important question in cell biology is how cytoskeletal proteins evolved and drove the development of novel structures and functions. Here we address the origin of SPIRE actin nucleators. Mammalian SPIREs work with RAB GTPases, formin (FMN
Externí odkaz:
https://doaj.org/article/0ef371bb0f37464e940f4e2fa0201a73
Autor:
Klas Hatje, Tony Kam-Thong, Nicolas Giroud, Antonio Saviano, Pauline Simo-Noumbissie, Nadine Kumpesa, Tobias Nilsson, François Habersetzer, Thomas F. Baumert, Nadege Pelletier, Marianne Forkel
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-12 (2024)
Abstract Chronic hepatitis B (CHB) is a major global health challenge. CHB can be controlled by antivirals but a therapeutic cure is lacking. CHB is characterized by limited HBV-specific T cell reactivity and functionality and expression of inhibitor
Externí odkaz:
https://doaj.org/article/c9c49586d0034ecf8069324ee36f3f71
Autor:
Gino Kwon, Annika Wiedemann, Lisa M. Steinheuer, Ana-Luisa Stefanski, Franziska Szelinski, Tomas Racek, Andreas Philipp Frei, Klas Hatje, Tony Kam-Thong, David Schubert, Thomas Schindler, Thomas Dörner, Kevin Thurley
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) share clinical as well as pathogenic similarities. Although previous studies suggest various abnormalities in different immune cell compartments, dedicated cell-type
Externí odkaz:
https://doaj.org/article/d842d9b1ede44c8c9b4c539caeb38071
Autor:
Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Next-generation cancer immunotherapies are designed to broaden the therapeutic repertoire by targeting new immune checkpoints including lymphocyte-activation gene 3 (LAG-3) and T cell immunoglobulin and mucin-domain containing-3 (TIM-3). Y
Externí odkaz:
https://doaj.org/article/d05c988c40044c0488968cfb22947d69
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Coiled-coil regions were among the first protein motifs described structurally and theoretically. The simplicity of the motif promises that coiled-coil regions can be detected with reasonable accuracy and precision in any protein sequence. H
Externí odkaz:
https://doaj.org/article/457f24aabd3c4d23a4754297cf759afa
Autor:
Hector Rincon-Arevalo, Annika Wiedemann, Ana-Luisa Stefanski, Marie Lettau, Franziska Szelinski, Sebastian Fuchs, Andreas Philipp Frei, Malte Steinberg, Tony Kam-Thong, Klas Hatje, Baerbel Keller, Klaus Warnatz, Andreas Radbruch, Andreia C. Lino, Eva Schrezenmeier, Thomas Dörner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Circulating CD11c+ B cells are a key phenomenon in certain types of autoimmunity but have also been described in the context of regular immune responses (i.e., infections, vaccination). Using mass cytometry to profile 46 different markers on individu
Externí odkaz:
https://doaj.org/article/880ec4a29f2f4fdd9fe4bdff19f5ee45
Publikováno v:
Stem Cell Research, Vol 46, Iss , Pp 101852- (2020)
Gene editing in human pluripotent stem cells (hPSC) is a powerful tool for understanding biology, for drug discovery and gene therapy. Naïve hPSC have been suggested to be superior for gene editing compared to conventional ‘primed’ hPSC. Using d
Externí odkaz:
https://doaj.org/article/8b7d78f2b80e4d8181f1b6211c4dbf54
Autor:
Amparo Garcia-Lopez, Francesca Tessaro, Hendrik R. A. Jonker, Anna Wacker, Christian Richter, Arnaud Comte, Nikolaos Berntenis, Roland Schmucki, Klas Hatje, Olivier Petermann, Gianpaolo Chiriano, Remo Perozzo, Daniel Sciarra, Piotr Konieczny, Ignacio Faustino, Guy Fournet, Modesto Orozco, Ruben Artero, Friedrich Metzger, Martin Ebeling, Peter Goekjian, Benoît Joseph, Harald Schwalbe, Leonardo Scapozza
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Spinal muscular atrophy (SMA) is an autosomal recessive disorder with no present cure. Here the authors perform an in vitro screening leading to the identification of a small molecule that alters the conformational dynamics of the TSL2 RNA structure
Externí odkaz:
https://doaj.org/article/cc1752fb9d394b0fb636e7fca670afcc
Autor:
Jitao David Zhang, Klas Hatje, Gregor Sturm, Clemens Broger, Martin Ebeling, Martine Burtin, Fabiola Terzi, Silvia Ines Pomposiello, Laura Badi
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background Gene expression data can be compromised by cells originating from other tissues than the target tissue of profiling. Failures in detecting such tissue heterogeneity have profound implications on data interpretation and reproducibi
Externí odkaz:
https://doaj.org/article/e2f3d7cda6a14257b97e1a96f5781ae5
Autor:
Simon Gutbier, Florian Wanke, Nadine Dahm, Anna Rümmelin, Silke Zimmermann, Klaus Christensen, Fabian Köchl, Anna Rautanen, Klas Hatje, Barbara Geering, Jitao David Zhang, Markus Britschgi, Sally A. Cowley, Christoph Patsch
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 13, p 4808 (2020)
Tissue-resident macrophages are key players in inflammatory processes, and their activation and functionality are crucial in health and disease. Numerous diseases are associated with alterations in homeostasis or dysregulation of the innate immune sy
Externí odkaz:
https://doaj.org/article/13cb682086054881af6f63f16df7280c