Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Klas G. Wiman"'
Autor:
Charlotte Strandgren, Klas G. Wiman
Publikováno v:
Upsala Journal of Medical Sciences, Vol 129, Pp 1-6 (2024)
Mutations in the TP53 tumor suppressor gene occur with high prevalence in a wide range of human tumors. A significant fraction of these mutations (around 10%) are nonsense mutations, creating a premature termination codon (PTC) that leads to the expr
Externí odkaz:
https://doaj.org/article/912e60d82e2c4e7eb61b9e8b11c64046
Autor:
Anderson Daniel Ramos, Ying Yu Liang, Olga Surova, Smaranda Bacanu, Marc-Antoine Gerault, Tamoghna Mandal, Sophia Ceder, Anette Langebäck, Albin Österroos, George A. Ward, Jonas Bergh, Klas G. Wiman, Sören Lehmann, Nayana Prabhu, Sara Lööf, Pär Nordlund
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114784- (2024)
Summary: Cellular phenotypes of apoptosis, as well as the activation of apoptosis caspase cascades, are well described. However, sequences and locations of early biochemical effector events after apoptosis initiation are still only partly understood.
Externí odkaz:
https://doaj.org/article/52b21ee609b64646a145af27d421b87c
Autor:
Angelos Heldin, Matko Cancer, Mireia Palomar-Siles, Susanne Öhlin, Meiqiongzi Zhang, Alexander Sun-Zhang, Anna Mariani, Jianping Liu, Vladimir J.N. Bykov, Klas G. Wiman
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 368-383 (2023)
The TP53 and PTEN tumour suppressor genes are inactivated by nonsense mutations in a significant fraction of human tumours. TP53 nonsense mutant tumours account for approximately one million new cancer cases per year worldwide. We have screened chemi
Externí odkaz:
https://doaj.org/article/daccee69e3db47eebcd34fa7604e554b
Autor:
Mireia Palomar-Siles, Angelos Heldin, Meiqiongzi Zhang, Charlotte Strandgren, Viktor Yurevych, Jip T. van Dinter, Sem A. G. Engels, Damon A. Hofman, Susanne Öhlin, Birthe Meineke, Vladimir J. N. Bykov, Sebastiaan van Heesch, Klas G. Wiman
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-17 (2022)
Abstract TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) induces full-length p53 in human tumor cells carrying R213X nonsense mutant TP53. Ribosome profiling visualized tran
Externí odkaz:
https://doaj.org/article/d20df1692ffe43d69b4b2923e7b6b3b8
Autor:
Qiang Zhang, Dimitrios-Ilias Balourdas, Bruno Baron, Alon Senitzki, Tali E. Haran, Klas G. Wiman, Thierry Soussi, Andreas C. Joerger
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-11 (2022)
Abstract The extremophile Alvinella pompejana, an annelid worm living on the edge of hydrothermal vents in the Pacific Ocean, is an excellent model system for studying factors that govern protein stability. Low intrinsic stability is a crucial factor
Externí odkaz:
https://doaj.org/article/6293f38a3c7d4577850a7e1f3760078f
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/0522a7b2dc31453c815d80ed55a8d2b6
Autor:
Sophia Ceder, Sofi E. Eriksson, Ying Yu Liang, Emarndeena H. Cheteh, Si Min Zhang, Kenji M. Fujihara, Julie Bianchi, Vladimir J. N. Bykov, Lars Abrahmsen, Nicholas J. Clemons, Pär Nordlund, Sean G. Rudd, Klas G. Wiman
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Abstract Asparaginase depletes extracellular asparagine in the blood and is an important treatment for acute lymphoblastic leukemia (ALL) due to asparagine auxotrophy of ALL blasts. Unfortunately, resistance occurs and has been linked to expression o
Externí odkaz:
https://doaj.org/article/b2b5eed6ca834936815c57813c137b8e
Autor:
Sophia Ceder, Sofi E. Eriksson, Ying Yu Liang, Emarndeena H. Cheteh, Si Min Zhang, Kenji M. Fujihara, Julie Bianchi, Vladimir J. N. Bykov, Lars Abrahmsen, Nicholas J. Clemons, Pär Nordlund, Sean G. Rudd, Klas G. Wiman
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/7a30218a8b2c440c80e8a3b947cee01f
Autor:
Naoise C. Synnott, Stephen F. Madden, Vladimir J.N. Bykov, John Crown, Klas G. Wiman, Michael J. Duffy
Publikováno v:
Translational Oncology, Vol 11, Iss 6, Pp 1343-1349 (2018)
TP53 is the most frequently mutated gene in human cancer and thus an attractive target for novel cancer therapy. Several compounds that can reactive mutant p53 protein have been identified. APR-246 is currently being tested in a phase II clinical tri
Externí odkaz:
https://doaj.org/article/953367fa30064e65a7cb18ecad94f3ab
Autor:
Lena Haffo, Jun Lu, Vladimir J. N. Bykov, Sebastin S. Martin, Xiaoyuan Ren, Lucia Coppo, Klas G. Wiman, Arne Holmgren
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246 (PRIMA-1Met) can reactive mutant p53 in tumor cells and trigger cell death by apo
Externí odkaz:
https://doaj.org/article/5919892998d44e63a8772d90b40e9d3a