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Akademický článek

Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy

Autor: Ulrike Müller, Julia Hentschel, Wibke K. Janhsen, Kerstin Hünniger, Uta-Christina Hipler, Jürgen Sonnemann, Wolfgang Pfister, Klas Böer, Thomas Lehmann, Jochen G. Mainz

Publikováno v: Mediators of Inflammation, Vol 2015 (2015)

Background. In cystic fibrosis (CF) the upper (UAW) and lower airways (LAW) are reservoirs for pathogens like Pseudomonas aeruginosa. The consecutive hosts’ release of proteolytic enzymes contributes to inflammation and progressive pulmonary destru

Externí odkaz: https://doaj.org/article/06e6cd127a364018a6c04e9f82828530

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Comparison of HbA1c Measurements using 3 Methods in 75 Patients Referred to One Outpatient Department

Autor: Thomas Lehmann, Joachim Pum, Ulrich A. Müller, Nicolle Müller, Klas Böer, J Roth, Sven Löbel

Publikováno v: Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 126(1)

Objective HbA1c is the most important surrogate parameter to assess the quality of diabetes care and is also used for the diagnosis of diabetes mellitus (DM) since 2010. We investigated the comparability of 3 HbA1c methods in the city of Jena (German

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c8eb2ba94eb5502a0cc6306c98d140
https://pubmed.ncbi.nlm.nih.gov/28704858

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Colonization of CF patients' upper airways with S. aureus contributes more decisively to upper airway inflammation than P. aeruginosa

Autor: Kerstin Hünniger, Thomas Lehmann, Michael Baier, Wibke K. Janhsen, Christin Arnold, Oliver Kurzai, Wolfgang Pfister, Julia Hentschel, Jochen G. Mainz, Uta-Christina Hipler, Klas Böer

Publikováno v: Medical microbiology and immunology. 205(5)

In cystic fibrosis (CF) patients' airways, inflammatory processes decisively contribute to remodeling and pulmonary destruction. The aims of this study were to compare upper airway (UAW) inflammation in the context of Staphylococcus aureus and Pseudo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a5c5bf0b2ea94a7c96fb009c286ff0
https://pubmed.ncbi.nlm.nih.gov/27377929

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CD62L on neutrophil granulocytes, a useful, complementary marker for the prediction of ventriculitis in blood-containing CSF

Autor: Klas Böer, Michael Kiehntopf, Wolfgang Pfister, Thomas Deufel, Heinz Vogelsang

Publikováno v: Clinical Biochemistry. 43:1351-1355

Objectives Presence of residual blood is a common problem in cerebrospinal fluid (CSF) diagnostics of ventriculitis. We hypothesised that neutrophil granulocytes in infected, blood-containing CSF lose CD62L expression. Therefore CD62L expression on n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec27ca166631a37acaaaf03390012b51
https://doi.org/10.1016/j.clinbiochem.2010.07.003

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Lactic acid is of low predictive value for the diagnosis of bacterial infection in ventricular cerebrospinal fluid samples containing residual blood

Autor: Michael Kiehntopf, Klas Böer, Wolfgang Pfister

Publikováno v: cclm. 48:1777-1780

Background: Lactic acid concentrations (LA) are an established marker of bacterial infection in cerebrospinal fluid (CSF). However, use of LA for the detection of infection in CSF with residual blood has not been fully evaluated. Methods: Analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67155310e4bf9af0fdfd6cb54770266f
https://doi.org/10.1515/cclm.2010.344

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Dynamics of soluble and cellular inflammatory markers in nasal lavage obtained from Cystic Fibrosis patients during intravenous antibiotic treatment

Autor: Udo R. Markert, Julia Hentschel, Ruth K. Michl, Nele Fischer, Klas Böer, N. Beiersdorf, Mathias W. Pletz, Jochen G. Mainz, Manuela Jäger, Franziska Doht, Thomas Lehmann, Peter M. Keller

Publikováno v: BMC Pulmonary Medicine

Background In cystic fibrosis (CF) patients, the upper airways display the same ion channel defect as evident in the lungs, resulting in chronic inflammation and infection. Recognition of the sinonasal area as a site of first and persistent infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e4f954d49f72d405b95572afd0c354
https://doi.org/10.1186/1471-2466-14-82

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Influences of nasal lavage collection-, processing- and storage methods on inflammatory markers--evaluation of a method for non-invasive sampling of epithelial lining fluid in cystic fibrosis and other respiratory diseases

Autor: Jürgen Sonnemann, Hipler C, Jochen G. Mainz, Klas Böer, Kerstin Hünniger, Nele Fischer, Ulrike Müller, Franziska Doht, Udo R. Markert, Oliver Kurzai, Julia Hentschel

Publikováno v: Journal of immunological methods. 404

Background Non-invasive sampling of airway epithelial-lining-fluid by nasal lavage (NL) is an emerging method to monitor allergy, infection and inflammation in patients with respiratory diseases. However, the influences of collection-, processing- an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6de4ae66f6e5c5cae77957af5b8ec7
https://pubmed.ncbi.nlm.nih.gov/24370751

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