Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Klarisa Rikova"'
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7994 (2009)
Aberrant activation of signaling pathways drives many of the fundamental biological processes that accompany tumor initiation and progression. Inappropriate phosphorylation of intermediates in these signaling pathways are a frequently observed molecu
Externí odkaz:
https://doaj.org/article/f784745dc84449cfb78e17c6e2b41208
Autor:
Mark L. Grimes, William Cook, Avi Ma'ayan, Lauren Foltz, Travis J. Wheeler, Peter Hornbeck, Alexander Lachmann, Bin Zhang, Ekaterina Smirnova, Klarisa Rikova, Tyler Levy, Michael J. Comb, Neil R. Clark, Jeremiah Gaiser, Benjamin Hall
Publikováno v:
Grimes, M, Hall, B, Foltz, L, Levy, T, Rikova, K, Gaiser, J, Cook, W, Smirnova, E, Wheeler, T, Clark, N R, Lachmann, A, Zhang, B, Hornbeck, P, Ma’ayan, A & Comb, M 2018, ' Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks ', Science Signaling, vol. 11, no. 531, pp. eaaq1087 . https://doi.org/10.1126/scisignal.aaq1087
Protein posttranslational modifications (PTMs) have typically been studied independently, yet many proteins are modified by more than one PTM type, and cell signaling pathways somehow integrate this information. We coupled immunoprecipitation using P
Autor:
Peter Hornbeck, Avi Ma'ayan, Gregory W. Gundersen, Nicolas F. Fernandez, Klarisa Rikova, Adeeb Rahman, Mark L. Grimes
Publikováno v:
Scientific Data
Most tools developed to visualize hierarchically clustered heatmaps generate static images. Clustergrammer is a web-based visualization tool with interactive features such as: zooming, panning, filtering, reordering, sharing, performing enrichment an
Autor:
Matthew P. Stokes, Anthony Possemato, Randall K. Wetzel, Jeffrey Mitchell, Michael J. Comb, Julie Nardone, Kimberly Lee, Judit Villén, Joan MacNeill, Roberto D. Polakiewicz, Jon M. Kornhauser, Gregory Innocenti, John Rush, Ailan Guo, Klarisa Rikova, Yi Wang, Steven P. Gygi
Publikováno v:
Proceedings of the National Academy of Sciences. 105:692-697
A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why some tumors respond and others do not. The observation that many tumors express EGF receptor (EGFR), yet only a small subset with EGFR-activating mutation
Autor:
Kimberly Lee, Tyler Levy, Xiaoying Jia, Hongbo Gu, Klarisa Rikova, Jian Min Ren, Vicky Yang, Matthew P. Stokes, Jeffrey C. Silva
Publikováno v:
Molecularcellular proteomics : MCP. 15(2)
A robust method was developed and optimized for enrichment and quantitative analysis of posttranslational modifications (PTMs) in serum/plasma samples by combining immunoaffinity purification and LC-MS/MS without depletion of abundant proteins. The m
Autor:
Hiromichi Ebi, Cyril H. Benes, Jeffrey A. Engelman, Ben Hall, Sean A. Beausoleil, Miriam Martini, Madhuri Nishtala, Anthony C. Faber, Klarisa Rikova, Jean J. Zhao, Carlotta Costa, Charles T. Jakubik, Youzhen Wang, Alan Huang, Emilio Hirsch
SummaryBYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (p110a), is currently in clinical trials for the treatment of solid tumors, especially luminal breast cancers with PIK3CA mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9c9a36c29dc390dab62dffd1de114d
http://hdl.handle.net/2318/155769
http://hdl.handle.net/2318/155769
Autor:
Anthony Possemato, Klarisa Rikova, Ben Hall, Jian Min Ren, Tyler Levy, Sean A. Beausoleil, Lonning Scott Michael, Mike Aguiar, Michael J. Comb, Kimberly Lee
Publikováno v:
Cancer Research. 76:LB-067
Lung cancer is the most common type of cancer in the U.S., with 5 yr. survival rates of 18% and 6% for non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC) patients, respectively. In spite of success with targeted therapies for
Autor:
Nabeel Bardeesy, Neil Hayes, Kwok-Kin Wong, Kathleyn A. Brandstetter, Autumn L. Jackson, Sauveur Michel Maira, Diego H. Castrillon, Julian Carretero, Kate McNamara, Norman E. Sharpless, Katherine Crosby, Matthew S. Buttarazzi, Hongbin Ji, Christa L. Borgman, Klarisa Rikova, Benjamin A. Sanofsky, Jeffrey A. Engelman, Geoffrey I. Shapiro, William Y. Kim, Carla F. Kim, Carlos Garcia-Echeverria, Ting-Lei Gu, Takeshi Shimamura, Zandra E. Walton, Jeffrey C. Silva, Matthew D. Wilkerson
Publikováno v:
Vol. 17 Issue 6: pp. 547-559
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
SummaryIn mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93589e4b889705600a6df2b5173bce1b
http://hdl.handle.net/10550/44802
http://hdl.handle.net/10550/44802
Autor:
Jon M. Kornhauser, Joan MacNeill, Jin Yuan, Roberto D. Polakiewicz, Qingfu Zeng, John Rush, Anthony Possemato, Zhi-Ping Tan, Julie Nardone, Daiqiang Li, Herbert Haack, Xinmin Zhou, Jeffrey Mitchell, Michael J. Comb, Matthew P. Stokes, Bradley L. Smith, Jian Min Ren, Cynthia Reeves, Jian Yu, Laura Sullivan, Ting-Lei Gu, Corey E. Bakalarski, Ailan Guo, Klarisa Rikova, Kimberly Lee, Judit Villén, Yerong Hu, Randy Wetzel, Steven P. Gygi, Yu Li
Publikováno v:
Cell. 131(6)
SummaryDespite the success of tyrosine kinase-based cancer therapeutics, for most solid tumors the tyrosine kinases that drive disease remain unknown, limiting our ability to identify drug targets and predict response. Here we present the first large
Autor:
Anthony Possemato, Yi Wang, Michael J. Comb, Lonning Scott Michael, Sean A. Beausoleil, Caroline Keroack, Ailan Guo, Joan Macneil, Tyler Levy, Klarisa Rikova, Daniel Mulhern, Kimberly Lee, Benjamin Hall, Jian M. Ren
Publikováno v:
Molecular Cancer Therapeutics. 12:B197-B197
Recent genomic-based studies have suggested ovarian cancer is a disease of copy instability, with 63 regions of focal amplification, rather than a disease driven by mutation. However, this analysis has been unable to identify changes in protein expre