The BeSt story: on strategy trials in rheumatoid arthritis.

Autor: Klarenbeek NB, Allaart CF, Kerstens PJS, Huizinga TWJ, Dijkmans BAC

Publikováno v: Current Opinion in Rheumatology; 2009 May, Vol. 21 Issue 3, p291-298, 8p

Lesional Psoriasis is Associated With Alterations in the Stratum Corneum Ceramide Profile and Concomitant Decreases in Barrier Function.

Autor: Rousel J; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Mergen C; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Bergmans ME; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands., Klarenbeek NB; Centre for Human Drug Research, Leiden, The Netherlands., der Kolk TN; Centre for Human Drug Research, Leiden, The Netherlands., van Doorn MBA; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Dermatology, Erasmus Medical Centre, Rotterdam, The Netherlands., Bouwstra JA; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Rissmann R; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Experimental dermatology [Exp Dermatol] 2024 Oct; Vol. 33 (10), pp. e15185.

The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers.

Autor: Jodl SJ; Bayer AG, Berlin, Germany., Ten Voorde W; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands., Klein S; Bayer AG, Berlin, Germany., Wagenfeld A; Bayer AG, Berlin, Germany., Zollmann FS; Pharma Consult, Berlin, Germany., Feldmüller M; Bayer AG, Berlin, Germany., Klarenbeek NB; Centre for Human Drug Research, Leiden, The Netherlands., de Bruin DT; Centre for Human Drug Research, Leiden, The Netherlands., Jansen MAA; Centre for Human Drug Research, Leiden, The Netherlands., Rissmann R; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden Academic Centre for Drug Research, Leiden, The Netherlands., Rohde B; Bayer AG, Berlin, Germany., Moerland M; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2024 Mar; Vol. 17 (3), pp. e13771.

Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study.

Autor: In 't Veld AE; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., Grievink HW; Centre for Human Drug Research, Leiden, The Netherlands.; Division of BioTherapeutics, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands., van der Plas JL; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., Eveleens Maarse BC; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., van Kraaij SJW; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., Woutman TD; Centre for Human Drug Research, Leiden, The Netherlands., Schoonakker M; Centre for Human Drug Research, Leiden, The Netherlands., Klarenbeek NB; Centre for Human Drug Research, Leiden, The Netherlands., de Kam ML; Centre for Human Drug Research, Leiden, The Netherlands., Kamerling IMC; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., Jansen MAA; Centre for Human Drug Research, Leiden, The Netherlands., Moerland M; Centre for Human Drug Research, Leiden, The Netherlands. mmoerland@chdr.nl.; Leiden University Medical Centre, Leiden, The Netherlands. mmoerland@chdr.nl.

Publikováno v: Immunologic research [Immunol Res] 2023 Aug; Vol. 71 (4), pp. 617-627. Date of Electronic Publication: 2023 Feb 22.

Administration of an adeno-associated viral vector expressing interferon-β in patients with inflammatory hand arthritis, results of a phase I/II study.

Autor: Vrouwe JPM; Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL, the Netherlands; Leiden University Medical Center (LUMC), Albinusdreef 2, Leiden, 2333 ZA, the Netherlands., Meulenberg JJM; Department of Oncology, Arthrogen B.V., Meibergdreef 45, Amsterdam, 1005BA, the Netherlands., Klarenbeek NB; Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL, the Netherlands; Leiden University Medical Center, Department of Internal Medicine, Albinusdreef 2, Leiden, 2333 ZA, the Netherlands., Navas-Cañete A; Leiden University Medical Center, Department of Radiology, Albinusdreef 2, Leiden, 2333 ZA, the Netherlands. Electronic address: a.navas_canete@lumc.nl., Reijnierse M; Leiden University Medical Center, Department of Radiology, Albinusdreef 2, Leiden, 2333 ZA, the Netherlands., Ruiterkamp G; Department of Oncology, Arthrogen B.V., Meibergdreef 45, Amsterdam, 1005BA, the Netherlands., Bevaart L; Department of Oncology, Arthrogen B.V., Meibergdreef 45, Amsterdam, 1005BA, the Netherlands., Lamers RJ; Department of Oncology, Arthrogen B.V., Meibergdreef 45, Amsterdam, 1005BA, the Netherlands., Kloppenburg M; Leiden University Medical Center, Department of Rheumatology, Albinusdreef 2, Leiden, 2333 ZA, the Netherlands., Nelissen RGHH; Leiden University Medical Center, Department of Orthopaedics, Albinusdreef 2, Leiden, 2333 ZA, the Netherlands., Huizinga TWJ; Leiden Academic Centre for Drug Research, PO box 9500, Leiden, 2300 RA, the Netherlands., Burggraaf J; Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL, the Netherlands; Leiden University Medical Center, Department of Internal Medicine, Albinusdreef 2, Leiden, 2333 ZA, the Netherlands; Leiden Academic Centre for Drug Research, PO box 9500, Leiden, 2300 RA, the Netherlands., Kamerling IMC; Centre for Human Drug Research, Zernikedreef 8, Leiden, 2333 CL, the Netherlands; Leiden University Medical Center, Department of Infectious Diseases, Albinusdreef 2, Leiden, 2333 ZA, the Netherlands. Electronic address: idevisser@chdr.nl.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2022 Jan; Vol. 30 (1), pp. 52-60. Date of Electronic Publication: 2021 Oct 06.