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IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34 ⁺  progenitor-derived NK cells.

Autor: Van der Meer JMR; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., Maas RJA; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., Guldevall K; Department of Applied Physics, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Klarenaar K; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., de Jonge PKJD; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., Evert JSH; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.; Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands., van der Waart AB; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., Cany J; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., Safrit JT; NantKwest, Culver City, CA, USA., Lee JH; ImmunityBio, Culver City, CA, USA., Wagena E; Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., Friedl P; Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.; David H. Koch Center for Applied Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Cancer Genomics Center, Utrecht, The Netherlands., Önfelt B; Department of Applied Physics, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Massuger LF; Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands., Schaap NPM; Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands., Jansen JH; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., Hobo W; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands., Dolstra H; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. harry.dolstra@radboudumc.nl.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 May; Vol. 70 (5), pp. 1305-1321. Date of Electronic Publication: 2020 Nov 03.