Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Klara Palme"'
Autor:
Annette Seidl, Fabian Birzele, Natascha Rieder, Martin Kaufmann, Stefan Scheiblich, Klaus Hirzel, Sabine Wilson, Gwendlyn Kollmorgen, Ben-Fillippo Krippendorff, Edgar Voss, Klara Palme, Christian Clemens, Frank Herting, Gerhard Niederfellner
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
RG7787 is a re-engineered mesothelin-targeted immunotoxin with reduced immunogenicity composed of a humanized anti-mesothelin Fab fragment and a B-cell epitope silenced 24 kD fragment of Pseudomonas exotoxin A. High prevalence of mesothelin-positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3808ab11c1535fd7c9de391a2e4e9c26
http://link.springer.com/article/10.1038/s41598-017-17329-7
http://link.springer.com/article/10.1038/s41598-017-17329-7
Autor:
Klara Palme, Pamela Wilfert, Stefan Scheiblich, Klaus Hirzel, Gerhard Niederfellner, Moritz Marcinowski, Bernd Satzinger, Annette Seidl, Christian Clemens, Frank Herting, Edgar Voss, Martin Kaufmann, Gwendlyn Kollmorgen
Publikováno v:
Cancer Research. 75:5321-5321
RG7787 is composed of a Fab fragment from an anti-MSLN antibody fused to a de-immunized and truncated pseudomonas endotoxin A variant. Once RG7787 is bound and internalized by MSLN positive cells, the toxin is transported to the cytosol, where it inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7ef1c53c0171cce92f14709769996de
https://doi.org/10.1158/1538-7445.am2015-5321
https://doi.org/10.1158/1538-7445.am2015-5321