Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Klara Kubelkova"'
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Francisella tularensis secretes tubular outer membrane vesicles (OMVs) that contain a number of immunoreactive proteins as well as virulence factors. We have reported previously that isolated Francisella OMVs enter macrophages, cumulate inside, and i
Externí odkaz:
https://doaj.org/article/8a0d0b92c9ad4268aac1449e0f505967
Autor:
Jela Hrnciarova, Klara Kubelkova, Vanda Bostik, Ivan Rychlik, Daniela Karasova, Vladimir Babak, Magdalena Datkova, Katerina Simackova, Ales Macela
Publikováno v:
Nutrients, Vol 16, Iss 13, p 1988 (2024)
The etiology and mechanisms of autism and autism spectrum disorder (ASD) are not yet fully understood. There is currently no treatment for ASD for providing significant improvement in core symptoms. Recent studies suggest, however, that ASD is associ
Externí odkaz:
https://doaj.org/article/23acb0cbbae645229d3cd81606a8a8a1
Autor:
Jaroslav Pejchal, Ales Tichy, Adela Kmochova, Lenka Fikejzlova, Klara Kubelkova, Marcela Milanova, Anna Lierova, Alzbeta Filipova, Lubica Muckova, Jana Cizkova
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Purpose: Insulin-like growth factor-1 (IGF-1) stimulates epithelial regeneration but may also induce life-threatening hypoglycemia. In our study, we first assessed its safety. Subsequently, we examined the effect of IGF-1 administered in different do
Externí odkaz:
https://doaj.org/article/dde1adc7d7e54647b7a2da64813cef20
Publikováno v:
Biology, Vol 12, Iss 4, p 499 (2023)
Engagement of PRRs in recognition of PAMPs or DAMPs is one of the processes that initiates cellular stress. These sensors are involved in signaling pathways leading to induction of innate immune processes. Signaling initiated by PRRs is associated wi
Externí odkaz:
https://doaj.org/article/ac9b175dc6164493beb174c72e5be7d8
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract There remains to this day a great gap in understanding as to the role of B cells and their products—antibodies and cytokines—in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the g
Externí odkaz:
https://doaj.org/article/783d0f22cbe14f2ab15a2718817c36e4
Autor:
Ivona Pavkova, Jana Klimentova, Jan Bavlovic, Lenka Horcickova, Klara Kubelkova, Erik Vlcak, Helena Raabova, Vlada Filimonenko, Ondrej Ballek, Jiri Stulik
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Francisella tularensis is known to release unusually shaped tubular outer membrane vesicles (OMV) containing a number of previously identified virulence factors and immunomodulatory proteins. In this study, we present that OMV isolated from the F. tu
Externí odkaz:
https://doaj.org/article/163eb5b758b34ae1adcefab92cde654e
Autor:
Anna Lierova, Jitka Kasparova, Jaroslav Pejchal, Klara Kubelkova, Marcela Jelicova, Jiri Palarcik, Lucie Korecka, Zuzana Bilkova, Zuzana Sinkorova
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
PurposeTherapeutic thorax irradiation as an intervention in lung cancer has its limitations due to toxic effects leading to pneumonitis and/or pulmonary fibrosis. It has already been confirmed that hyaluronic acid (HA), an extracellular matrix glycos
Externí odkaz:
https://doaj.org/article/d9b5bbb9e988403cb6ea5547d3f313d4
Autor:
Klara Kubelkova, Ales Macela
Publikováno v:
Microorganisms, Vol 9, Iss 10, p 2136 (2021)
Immune responses to intracellular pathogens depend largely upon the activation of T helper type 1-dependent mechanisms. The contribution of B cells to establishing protective immunity has long been underestimated. Francisella tularensis, including a
Externí odkaz:
https://doaj.org/article/cac51d70d92241faae4477c2a6857262
Autor:
Klara Kubelkova, Ales Macela
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Primary interaction of an intracellular bacterium with its host cell is initiated by activation of multiple signaling pathways in response to bacterium recognition itself or as cellular responses to stress induced by the bacterium. The leading molecu
Externí odkaz:
https://doaj.org/article/3bd9da3c1de94ddc8a7712107c30a9bc
Autor:
Ales Macela, Klara Kubelkova
Publikováno v:
Pathogens, Vol 10, Iss 3, p 380 (2021)
SARS-CoV-2 infection induces the production of autoantibodies, which is significantly associated with complications during hospitalization and a more severe prognosis in COVID-19 patients. Such a response of the patient’s immune system may reflect
Externí odkaz:
https://doaj.org/article/3eff3a09e58b43b0b9dfa0d14c3fd6fa