Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Klara Kirsch"'
Autor:
Jong Il Ahn, Liang Zhang, Harsha Ravishankar, Lixin Fan, Klara Kirsch, Yan Zeng, Lingjun Meng, Jung-Eun Park, Hye-Yeoung Yun, Rodolfo Ghirlando, Buyong Ma, David Ball, Bonsu Ku, Ruth Nussinov, Jeremy D. Schmit, William F. Heinz, Seung Jun Kim, Tatiana Karpova, Yun-Xing Wang, Kyung S. Lee
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/4954415703224bd39f8ad4b7d54ac61c
Autor:
Jong Il Ahn, Liang Zhang, Harsha Ravishankar, Lixin Fan, Klara Kirsch, Yan Zeng, Lingjun Meng, Jung-Eun Park, Hye-Yeoung Yun, Rodolfo Ghirlando, Buyong Ma, David Ball, Bonsu Ku, Ruth Nussinov, Jeremy D. Schmit, William F. Heinz, Seung Jun Kim, Tatiana Karpova, Yun-Xing Wang, Kyung S. Lee
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-20 (2023)
Abstract Proper organization of intracellular assemblies is fundamental for efficient promotion of biochemical processes and optimal assembly functionality. Although advances in imaging technologies have shed light on how the centrosome is organized,
Externí odkaz:
https://doaj.org/article/06aa6e8547484fe7b186bef73965f8dc
Autor:
Jung-Eun Park, Hobin Lee, Paola Oliva, Klara Kirsch, Bora Kim, Jong Il Ahn, Celeste N. Alverez, Snehal Gaikwad, Kristopher W. Krausz, Robert O’Connor, Ganesha Rai, Anton Simeonov, Beverly A. Mock, Frank J. Gonzalez, Kyung S. Lee, Kenneth A. Jacobson
Publikováno v:
ACS Pharmacology & Translational Science. 6:422-446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b04cc3280d43aaf18a6dcd67d08e1538
https://doi.org/10.1021/acsptsci.2c00250
https://doi.org/10.1021/acsptsci.2c00250
Autor:
Mariana Shumliakivska, Guillermo Luxán, Inga Hemmerling, Marina Scheller, Xue Li, Carsten Müller-Tidow, Bianca Schuhmacher, Zhengwu Sun, Andreas Dendorfer, Alisa Debes, Simone-Franziska Glaser, Marion Muhly-Reinholz, Klara Kirschbaum, Jedrzej Hoffmann, Eike Nagel, Valentina O. Puntmann, Sebastian Cremer, Florian Leuschner, Wesley Tyler Abplanalp, David John, Andreas M. Zeiher, Stefanie Dimmeler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Hematopoietic mutations in epigenetic regulators like DNA methyltransferase 3 alpha (DNMT3A), play a pivotal role in driving clonal hematopoiesis of indeterminate potential (CHIP), and are associated with unfavorable outcomes in patients suf
Externí odkaz:
https://doaj.org/article/20a09696ec974f6db501fff88d7fff78
Autor:
András Zeke, Tamás Takács, Péter Sok, Krisztina Németh, Klára Kirsch, Péter Egri, Ádám Levente Póti, Isabel Bento, Gábor E. Tusnády, Attila Reményi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this en
Externí odkaz:
https://doaj.org/article/f6d3c3032ebe40f894a83f92cc0e664c
Autor:
Katharina C. Kiefer, Sebastian Cremer, Evangelia Pardali, Birgit Assmus, Khalil Abou‐El‐Ardat, Klara Kirschbaum, Lena Dorsheimer, Tina Rasper, Alexander Berkowitsch, Hubert Serve, Stefanie Dimmeler, Andreas M. Zeiher, Michael A. Rieger
Publikováno v:
ESC Heart Failure, Vol 8, Iss 3, Pp 1873-1884 (2021)
Abstract Aims Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (V
Externí odkaz:
https://doaj.org/article/54d19ff862694ff0856fac32d8a2abdc
Autor:
Klára Kirsch, András Zeke, Orsolya Tőke, Péter Sok, Ashish Sethi, Anna Sebő, Ganesan Senthil Kumar, Péter Egri, Ádám L. Póti, Paul Gooley, Wolfgang Peti, Isabel Bento, Anita Alexa, Attila Reményi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphor
Externí odkaz:
https://doaj.org/article/8e3a384b4b1a49a98424465168b5b1a6
Autor:
András Zeke, Tomas Bastys, Anita Alexa, Ágnes Garai, Bálint Mészáros, Klára Kirsch, Zsuzsanna Dosztányi, Olga V Kalinina, Attila Reményi
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 11, Pp 1-21 (2015)
Abstract Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling. However, how these enzymes can be involved in such a broad spectrum of physiological functions is not understood. Systematic discovery of MAPK netw
Externí odkaz:
https://doaj.org/article/0d3a80ceb73f45898e010580f6b898aa
Autor:
Michael O Breckwoldt, Julia Bode, Felix T Kurz, Angelika Hoffmann, Katharina Ochs, Martina Ott, Katrin Deumelandt, Thomas Krüwel, Daniel Schwarz, Manuel Fischer, Xavier Helluy, David Milford, Klara Kirschbaum, Gergely Solecki, Sara Chiblak, Amir Abdollahi, Frank Winkler, Wolfgang Wick, Michael Platten, Sabine Heiland, Martin Bendszus, Björn Tews
Publikováno v:
eLife, Vol 5 (2016)
Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires imaging methods to assess treatment effects and disease progression. Until now mapping of the tumor vasculature has been difficult. We have developed a combine
Externí odkaz:
https://doaj.org/article/6cf1ba2274d448389f273fdc197771ff