Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Klara Höning"'
Autor:
Katrin J. Czogalla, Kerstin Liphardt, Klara Höning, Veit Hornung, Arijit Biswas, Matthias Watzka, Johannes Oldenburg
Publikováno v:
Blood Advances, Vol 2, Iss 6, Pp 691-702 (2018)
Abstract: Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo, VKORC1 reduces vitamin K to sustain γ-carboxylation of vitamin K-depen
Externí odkaz:
https://doaj.org/article/f4c0d6d5c29042b79cd901c0209c7844
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The use of site-specific gene insertion is a powerful method for investigating gene function. Here the authors describe CRISPaint, a universal tagging system using CRISPR-Cas9 to insert genes in an NHEJ dependent manner.
Externí odkaz:
https://doaj.org/article/4ee6796f750540338a9604189f2c3ea7
Autor:
Veit Hornung, Heike Singer, Klara Höning, Katrin J. Czogalla-Nitsche, Katrin Kraus, S Ghosh, Arijit Biswas, Johannes Oldenburg, Jens Müller, Francesco Forin, Matthias Watzka
Publikováno v:
Human Mutation. 43:42-55
γ-Glutamyl carboxylase (GGCX) catalyses γ-carboxylation of 15 different vitamin K dependent (VKD) proteins. Pathogenic variants in GGCX cause a rare hereditary bleeding disorder called Vitamin K dependent coagulation factor deficiency type 1 (VKCFD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cceeac0a9f39124f715e07f7697cef4
https://doi.org/10.1002/humu.24300
https://doi.org/10.1002/humu.24300
Autor:
Katrin Kraus, Arijit Biswas, Francesco Forin, Jens Müller, Heike Singer, Anna-Lena Buhl, Matthias Watzka, Johannes Oldenburg, S Ghosh, Klara Höning, Veit Hornung, Katrin J. Czogalla-Nitsche
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:1412-1424
Background Vitamin K dependent coagulation factor deficiency type 1 (VKCFD1) is a rare hereditary bleeding disorder caused by mutations in γ-Glutamyl carboxylase (GGCX). VKCFD1 patients are treated life-long with high doses of vitamin K in order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bc23c36c9fff37747e8b6d2da5fbeb
https://doi.org/10.1111/jth.15238
https://doi.org/10.1111/jth.15238
Autor:
Johannes Oldenburg, Veit Hornung, Arijit Biswas, Kerstin Liphardt, Matthias Watzka, Katrin J. Czogalla, Klara Höning
Publikováno v:
Blood Advances. 2:691-702
Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo, VKORC1 reduces vitamin K to sustain γ-carboxylation of vitamin K-dependent prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061db01697df28353c6a79448605eadd
https://doi.org/10.1182/bloodadvances.2017006775
https://doi.org/10.1182/bloodadvances.2017006775
Autor:
Trine H. Mogensen, Line Lykke Andersen, Veit Hornung, Nanna Mørk, Rune Hartmann, Klara Höning, Carsten Scavenius, Jan J. Enghild, Ewa Terczyńska-Dyla, Mette Christiansen
Publikováno v:
Andersen, L L, Terczyńska-Dyla, E, Mørk, N, Scavenius, C, Enghild, J J, Höning, K, Hornung, V, Christiansen, M, Mogensen, T H & Hartmann, R 2019, ' Frequently used bioinformatics tools overestimate the damaging effect of allelic variants ', Genes and Immunity, vol. 20, no. 1, pp. 10-22 . https://doi.org/10.1038/s41435-017-0002-z
We selected two sets of naturally occurring human missense allelic variants within innate immune genes. The first set represented eleven non-synonymous variants in six different genes involved in interferon (IFN) induction, present in a cohort of pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfa079599c7d0dd0a45a7a36caaa35e
https://doi.org/10.1038/s41435-017-0002-z
https://doi.org/10.1038/s41435-017-0002-z
Autor:
Katrin J. Czogalla, Veit Hornung, Kerstin Liphardt, Arijit Biswas, Matthias Watzka, Klara Höning, Johannes Oldenburg
Publikováno v:
Nature Structural & Molecular Biology. 24:77-85
Vitamin K epoxide reductase (VKOR) catalyzes the reduction of vitamin K quinone and vitamin K 2,3-epoxide, a process essential to sustain γ-carboxylation of vitamin K-dependent proteins. VKOR is also a therapeutic target of warfarin, a treatment for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7623221f4c051717708fafa9d0720f9
https://doi.org/10.1038/nsmb.3338
https://doi.org/10.1038/nsmb.3338
Autor:
Veit Hornung, Genevieve Pepin, Michael P. Gantier, Klara Höning, Jonathan Ferrand, Mark A. Behlke, Jason E. Cain, Daniel J. Gough, W. Samantha N. Jayasekara, Bryan R.G. Williams
Publikováno v:
Nucleic Acids Research
ResearcherID
ResearcherID
Gene-recombinase technologies, such as Cre/loxP-mediated DNA recombination, are important tools in the study of gene function, but have potential side effects due to damaging activity on DNA. Here we show that DNA recombination by Cre instigates a ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c24a1878be24ed03f1f1d034fd80f6
https://doi.org/10.1093/nar/gkw405
https://doi.org/10.1093/nar/gkw405
Autor:
Lars Østergaard, Torben F. Ørntoft, Søren R. Paludan, Nanna Mørk, Trine H. Mogensen, Rune Hartmann, Klara Höning, Hans Henrik Gad, Jacob Giehm Mikkelsen, Emil Kofod-Olsen, Veit Hornung, Line Lykke Andersen, Sofie E. Jørgensen, Kristian Alsbjerg Skipper, Ryo Narita, Takashi Fujita, Mette Christiansen, Line S. Reinert
Publikováno v:
Andersen, L L, Mørk, N, Reinert, L S, Kofod-Olsen, E, Narita, R, Jørgensen, S E, Skipper, K A, Höning, K, Gad, H H, Østergaard, L, Ørntoft, T F, Hornung, V, Paludan, S R, Mikkelsen, J G, Fujita, T, Christiansen, M, Hartmann, R & Mogensen, T H 2015, ' Functional IRF3 deficiency in a patient with herpes simplex encephalitis ', Journal of Experimental Medicine, vol. 212, no. 9, pp. 1371-9 . https://doi.org/10.1084/jem.20142274
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Andersen et al. identify a novel genetic etiology of herpes encephalitis in an adult patient carrying a heterozygous loss-of-function mutation in the IRF3 gene. This mutation results in impaired INF production in response to viral infection
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a5878b3732e5a2dfb7ad93d686af4f
https://pure.au.dk/portal/da/publications/functional-irf3-deficiency-in-a-patient-with-herpes-simplex-encephalitis(965c2037-cf2b-4237-bcfb-f8116d7cf771).html
https://pure.au.dk/portal/da/publications/functional-irf3-deficiency-in-a-patient-with-herpes-simplex-encephalitis(965c2037-cf2b-4237-bcfb-f8116d7cf771).html
Autor:
Veit Hornung, Klara Höning, Liudmila Andreeva, Andrew V Kubarenko, Tobias Schmidt, Marion Goldeck, Arun K. Mankan, Moritz M. Gaidt, Dhruv Chauhan, Karl-Peter Hopfner
Intracellular recognition of non-self and also self-nucleic acids can result in the initiation of potent pro-inflammatory and antiviral cytokine responses. Most recently, cGAS was shown to be critical for the recognition of cytoplasmic dsDNA. Binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e7b9e67fe6a47b86dca6d9f9772c70
https://europepmc.org/articles/PMC4282641/
https://europepmc.org/articles/PMC4282641/