Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Klabatsa, A."'
Autor:
Busacca, S., Law, E.W.P., Powley, I.R., Proia, D.A., Sequeira, M., Le Quesne, J., Klabatsa, A., Edwards, J.M., Matchett, K.B., Luo, J.L., Pringle, J.H., El-Tanani, Mohamed, MacFarlane, M., Fennell, D.A.
Yes
Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a promising anti-cancer strategy. The mechanisms underpinning apoptosis activation following HSP90 inhibition and how they are modified during acquired dr
Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a promising anti-cancer strategy. The mechanisms underpinning apoptosis activation following HSP90 inhibition and how they are modified during acquired dr
Externí odkaz:
http://hdl.handle.net/10454/8406
Autor:
Dario Barbone, Carlo Follo, Nohemy Echeverry, Victor H Gerbaudo, Astero Klabatsa, Raphael Bueno, Emanuela Felley-Bosco, V Courtney Broaddus
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134825 (2015)
Malignant pleural mesothelioma is a highly chemoresistant solid tumor. We have studied this apoptotic resistance using in vitro and ex vivo three-dimensional models, which acquire a high level of chemoresistance that can be reduced by PI3K/mTOR inhib
Externí odkaz:
https://doaj.org/article/c32e69aebb8b4def990b7e0dba22f2cf
Autor:
Sara Busacca, Alex D Chacko, Astero Klabatsa, Kenneth Arthur, Michael Sheaff, Dario Barbone, Luciano Mutti, Vignesh K Gunasekharan, Julia J Gorski, Mohamed El-Tanani, V Courtney Broaddus, Giovanni Gaudino, Dean A Fennell
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65489 (2013)
Based on promising preclinical efficacy associated with the 20S proteasome inhibitor bortezomib in malignant pleural mesothelioma (MPM), two phase II clinical trials have been initiated (EORTC 08052 and ICORG 05-10). However, the potential mechanisms
Externí odkaz:
https://doaj.org/article/5d8e2afc12944741abf07215256c251c
Autor:
Sara Busacca, Alex D. Chacko, Astero Klabatsa, Kenneth Arthur, Michael Sheaff, Dario Barbone, Luciano Mutti, Vignesh K. Gunasekharan, Julia J. Gorski, Mohamed El-Tanani, V. Courtney Broaddus, Giovanni Gaudino, Dean A. Fennell
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/9e1ffb25bffe4dc6bf2b6d0d3d021472
Publikováno v:
In Lung Cancer 2006 51(1):53-59
Autor:
Klabatsa, Astero1, Chicklore, Sugama2, Barrington, Sally2, Goh, Vicky2, Lang-Lazdunski, Loic1, Cook, Gary gary.cook@kcl.ac.uk
Publikováno v:
European Journal of Nuclear Medicine & Molecular Imaging. Feb2014, Vol. 41 Issue 2, p276-282. 7p.
Autor:
Ritu R. Gill, Thorsten Persigehl, Samuel G. Armato, Astero Klabatsa, M. Feigen, Zacariah E. Labby, Johan Coolen
Publikováno v:
Lung Cancer. 82:190-196
Imaging of malignant pleural mesothelioma (MPM) is essential to the diagnosis, assessment, and monitoring of this disease. The complex morphology and growth pattern of MPM, however, create unique challenges for image acquisition and interpretation. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b624aff0caebb82eaa302068cce59aa
https://doi.org/10.1016/j.lungcan.2013.08.005
https://doi.org/10.1016/j.lungcan.2013.08.005
Autor:
Jin-Li Luo, Kyle B. Matchett, Mohamed El-Tanani, Marion MacFarlane, Astero Klabatsa, Ian R. Powley, D.A. Proia, M. Sequeira, J. Le Quesne, Dean A. Fennell, Edward W. P. Law, Sara Busacca, J.H. Pringle, J.M. Edwards
Publikováno v:
Busacca, S, Law, EWP, Powley, IR, Proia, DA, Sequeira, M, Le Quesne, J, Klabatsa, A, Edwards, JM, Matchett, KB, Luo, JL, Pringle, JH, El-Tanani, M, McFarlane, M & Fennell, DA 2016, ' Resistance to HSP90 inhibition involving loss of MCL1 addiction ', Oncogene, vol. 35, pp. 1483-1492 . https://doi.org/10.1038/onc.2015.213
Busacca, S, Law, E W P, Powley, I R, Proia, D A, Sequeira, M, Le Quesne, J, Klabatsa, A, Edwards, J M, Matchett, K B, Luo, J L, Pringle, J H, El-Tanani, M, MacFarlane, M & Fennell, D A 2016, ' Resistance to HSP90 inhibition involving loss of MCL1 addiction ', Oncogene, vol. 35, no. 12, pp. 1483-1492 . https://doi.org/10.1038/onc.2015.213
Oncogene
Busacca, S, Law, E W P, Powley, I R, Proia, D A, Sequeira, M, Le Quesne, J, Klabatsa, A, Edwards, J M, Matchett, K B, Luo, J L, Pringle, J H, El-Tanani, M, MacFarlane, M & Fennell, D A 2016, ' Resistance to HSP90 inhibition involving loss of MCL1 addiction ', Oncogene, vol. 35, no. 12, pp. 1483-1492 . https://doi.org/10.1038/onc.2015.213
Oncogene
Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a promising anti-cancer strategy. The mechanisms underpinning apoptosis activation following HSP90 inhibition and how they are modified during acquired drug resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ec014309d79dd2760ee3ecf10f79b6
https://pure.qub.ac.uk/en/publications/resistance-to-hsp90-inhibition-involving-loss-of-mcl1-addiction(f119b81e-e804-440d-a7c6-a941ed519613).html
https://pure.qub.ac.uk/en/publications/resistance-to-hsp90-inhibition-involving-loss-of-mcl1-addiction(f119b81e-e804-440d-a7c6-a941ed519613).html
Autor:
Broaddus, V Courtney, Barbone, D, Follo, C, Echeverry, N, Gerbaudo, VH, Klabatsa, A, Bueno, R, Felley-Bosco, E, Broaddus, VC
Publikováno v:
Broaddus, V Courtney; Barbone, D; Follo, C; Echeverry, N; Gerbaudo, VH; Klabatsa, A; et al.(2015). Autophagy correlates with the therapeutic responsiveness of Malignant pleural mesothelioma in 3D models. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1hs0b9n8
© 2015 Barbone et al.Malignant pleural mesothelioma is a highly chemoresistant solid tumor. We have studied this apoptotic resistance using in vitro and ex vivo three-dimensional models, which acquire a high level of chemoresistance that can be redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::bc9b327124bd3132be9b39d49f82f454
http://www.escholarship.org/uc/item/1hs0b9n8
http://www.escholarship.org/uc/item/1hs0b9n8