Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Klaas W. Mulder"'
Autor:
Georgina Peñalosa-Ruiz, Vicky Bousgouni, Jan P. Gerlach, Susan Waarlo, Joris V. van de Ven, Tim E. Veenstra, José C.R. Silva, Simon J. van Heeringen, Chris Bakal, Klaas W. Mulder, Gert Jan C. Veenstra
Publikováno v:
Stem Cell Reports, Vol 12, Iss 4, Pp 743-756 (2019)
Summary: Differentiated cells are epigenetically stable, but can be reprogrammed to pluripotency by expression of the OSKM transcription factors. Despite significant effort, relatively little is known about the cellular requirements for reprogramming
Externí odkaz:
https://doaj.org/article/51f683d499ae437386ac566ebd0aef86
Publikováno v:
PeerJ, Vol 8, p e8952 (2020)
Reprogramming somatic cells to induced pluripotent stem cells (iPSC) succeeds only in a small fraction of cells within the population. Reprogramming occurs in distinctive stages, each facing its own bottlenecks. It initiates with overexpression of tr
Externí odkaz:
https://doaj.org/article/f3730b8caa664dcca0f8bc305b101e18
Autor:
Roderick A.P.M. van Eijl, Jessie A.G.L. van Buggenum, Sabine E.J. Tanis, Joost Hendriks, Klaas W. Mulder
Publikováno v:
iScience, Vol 9, Iss , Pp 412-422 (2018)
Summary: Epidermal homeostasis requires balanced and coordinated adult stem cell renewal and differentiation. These processes are controlled by both extracellular signaling and by cell intrinsic transcription regulatory networks, yet how these contro
Externí odkaz:
https://doaj.org/article/376135bc88fd479f858ecc4285c222e9
Autor:
Jessie A. G. van Buggenum, Jan P. Gerlach, Sabine E. J. Tanis, Mark Hogeweg, Pascal W. T. C. Jansen, Jesse Middelwijk, Ruud van der Steen, Michiel Vermeulen, Hendrik G. Stunnenberg, Cornelis A. Albers, Klaas W. Mulder
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Detecting proteins and post-translational modifications is important for drug screens, but the number of proteins measurable simultaneously is limited. Here the authors use antibodies tagged with DNA barcodes and high-throughput sequencing to detect
Externí odkaz:
https://doaj.org/article/aee29dc4444b4d96b9ebc997bd57935e
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract In this study, we originally aimed to characterize the potential role of Argonaute 2 (AGO2) in the nucleus, a key protein of the miRNA machinery. We combined Chromatin Immunoprecipitation (ChIP) with high throughput sequencing (ChIP-seq) and
Externí odkaz:
https://doaj.org/article/9349e82891754ac5af58d4cce70e19dc
Autor:
Jieqiong Qu, Sabine E.J. Tanis, Jos P.H. Smits, Evelyn N. Kouwenhoven, Martin Oti, Ellen H. van den Bogaard, Colin Logie, Hendrik G. Stunnenberg, Hans van Bokhoven, Klaas W. Mulder, Huiqing Zhou
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3490-3503.e4 (2018)
Summary: Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and differentiation. Mutations in the p63 DNA-binding domain are associated with ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome. How
Externí odkaz:
https://doaj.org/article/6919d3e388824bdd9a978149c19f51f2
Autor:
Arjan F Theil, Alex Pines, Tuğba Kalayci, José M Heredia‐Genestar, Anja Raams, Marion H Rietveld, Sriram Sridharan, Sabine EJ Tanis, Klaas W Mulder, Nesimi Büyükbabani, Birsen Karaman, Zehra O Uyguner, Hülya Kayserili, Jan HJ Hoeijmakers, Hannes Lans, Jeroen AA Demmers, Joris Pothof, Umut Altunoglu, Abdoelwaheb El Ghalbzouri, Wim Vermeulen
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-27 (2023)
Abstract The brittle hair syndrome Trichothiodystrophy (TTD) is characterized by variable clinical features, including photosensitivity, ichthyosis, growth retardation, microcephaly, intellectual disability, hypogonadism, and anaemia. TTD‐associate
Externí odkaz:
https://doaj.org/article/00a4d41179d0455f867ed390b4be7d8b
Autor:
Fiona M. Watt, Andrew H. Sims, Scott K. Lyons, David Wei-Min Tan, Klaas W. Mulder, Stephen J. Goldie
Quicktime file - 7.8MB, Movies of cell behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695e096c918b931209d9852de75b7386
https://doi.org/10.1158/0008-5472.22391583.v1
https://doi.org/10.1158/0008-5472.22391583.v1
Autor:
Fiona M. Watt, Andrew H. Sims, Scott K. Lyons, David Wei-Min Tan, Klaas W. Mulder, Stephen J. Goldie
New therapeutic strategies are needed to improve treatment of head and neck squamous cell carcinoma (HNSCC), an aggressive tumor with poor survival rates. FRMD4A is a human epidermal stem cell marker implicated previously in epithelial polarity that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::876ac7dc6a9ca8045dd3bcd8052c5eb8
https://doi.org/10.1158/0008-5472.c.6503295.v1
https://doi.org/10.1158/0008-5472.c.6503295.v1