Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Klaas W Mulder"'
Autor:
Arjan F Theil, Alex Pines, Tuğba Kalayci, José M Heredia‐Genestar, Anja Raams, Marion H Rietveld, Sriram Sridharan, Sabine EJ Tanis, Klaas W Mulder, Nesimi Büyükbabani, Birsen Karaman, Zehra O Uyguner, Hülya Kayserili, Jan HJ Hoeijmakers, Hannes Lans, Jeroen AA Demmers, Joris Pothof, Umut Altunoglu, Abdoelwaheb El Ghalbzouri, Wim Vermeulen
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract The brittle hair syndrome Trichothiodystrophy (TTD) is characterized by variable clinical features, including photosensitivity, ichthyosis, growth retardation, microcephaly, intellectual disability, hypogonadism, and anaemia. TTD‐associate
Externí odkaz:
https://doaj.org/article/00a4d41179d0455f867ed390b4be7d8b
Autor:
Gerdine J Stout, Edwin C A Stigter, Paul B Essers, Klaas W Mulder, Annemieke Kolkman, Dorien S Snijders, Niels J F van den Broek, Marco C Betist, Hendrik C Korswagen, Alyson W MacInnes, Arjan B Brenkman
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp n/a-n/a (2013)
Mutations in the daf‐2 gene of the conserved Insulin/Insulin‐like Growth Factor (IGF‐1) pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is completely suppressed by deletion of Forkhead transcription factor daf
Externí odkaz:
https://doaj.org/article/d5f1cc4c270e464b839147f717d3960c
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 6, p e1002566 (2012)
Combinatorial gene perturbations provide rich information for a systematic exploration of genetic interactions. Despite successful applications to bacteria and yeast, the scalability of this approach remains a major challenge for higher organisms suc
Externí odkaz:
https://doaj.org/article/79ee6acd63d44cc3a060fcbb94e8580b
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 12, p e1001034 (2010)
Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance of pluripotency and lineage specification are poorly understood, b
Externí odkaz:
https://doaj.org/article/f18e0692cb8247ad92f69138b3d70e8b
Autor:
Nga-Chi Lau, Klaas W Mulder, Arjan B Brenkman, Shabaz Mohammed, Niels J F van den Broek, Albert J R Heck, H Th Marc Timmers
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9864 (2010)
The evolutionarily conserved Ccr4-Not and Bur1/2 kinase complexes are functionally related in Saccharomyces cerevisiae. In this study, we further explore the relationship between the subunits Not4p and Bur2p.First, we investigated the presence of pos
Externí odkaz:
https://doaj.org/article/566d27366ee84379b185e76468417525
Autor:
Fiona M. Watt, Andrew H. Sims, Scott K. Lyons, David Wei-Min Tan, Klaas W. Mulder, Stephen J. Goldie
Quicktime file - 7.8MB, Movies of cell behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695e096c918b931209d9852de75b7386
https://doi.org/10.1158/0008-5472.22391583.v1
https://doi.org/10.1158/0008-5472.22391583.v1
Autor:
Fiona M. Watt, Andrew H. Sims, Scott K. Lyons, David Wei-Min Tan, Klaas W. Mulder, Stephen J. Goldie
New therapeutic strategies are needed to improve treatment of head and neck squamous cell carcinoma (HNSCC), an aggressive tumor with poor survival rates. FRMD4A is a human epidermal stem cell marker implicated previously in epithelial polarity that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::876ac7dc6a9ca8045dd3bcd8052c5eb8
https://doi.org/10.1158/0008-5472.c.6503295.v1
https://doi.org/10.1158/0008-5472.c.6503295.v1
Autor:
Esther Hoste, Sergio González, Louis Boon, Mozes Sze, Hanna-Kaisa Vikkula, Geert van Loo, Ignacia Fuentes, Klaas W. Mulder, Ria Roelandt, Christian Maueröder, Julio C. Salas-Alanis, Lisette Van Hove, Amanda Gonçalves, Wim Declercq, Leen Catrysse, Dyah W Karjosukarso, Bastiaan Maes, Robert F. Schwabe, Kodi S. Ravichandran, Eef Parthoens, Francis Palisson, Yvan Saeys, Liesbet Martens, Peter Huebener
Publikováno v:
Cell Reports, 29, 2689-2701
CELL REPORTS
Cell Reports, 29, 9, pp. 2689-2701
Cell Reports, Vol 29, Iss 9, Pp 2689-2701.e4 (2019)
Cell Reports
CELL REPORTS
Cell Reports, 29, 9, pp. 2689-2701
Cell Reports, Vol 29, Iss 9, Pp 2689-2701.e4 (2019)
Cell Reports
Summary: Regenerative responses predispose tissues to tumor formation by largely unknown mechanisms. High-mobility group box 1 (HMGB1) is a danger-associated molecular pattern contributing to inflammatory pathologies. We show that HMGB1 derived from
Autor:
Roderick A. P. M. van Eijl, Joost Hendriks, Jessie A.G.L. van Buggenum, Klaas W. Mulder, Sabine E.J. Tanis
Publikováno v:
iScience
iScience, 9, pp. 412-422
iScience, 9, 412-422
iScience, Vol 9, Iss, Pp 412-422 (2018)
iScience, 9, pp. 412-422
iScience, 9, 412-422
iScience, Vol 9, Iss, Pp 412-422 (2018)
Summary Epidermal homeostasis requires balanced and coordinated adult stem cell renewal and differentiation. These processes are controlled by both extracellular signaling and by cell intrinsic transcription regulatory networks, yet how these control