Zobrazeno 1 - 10
of 450
pro vyhledávání: '"Klaas Nicolay"'
Publikováno v:
Molecules, Vol 20, Iss 7, Pp 12076-12092 (2015)
Membrane type-1 matrix metalloproteinase (MT1-MMP or MMP-14) plays an important role in adverse cardiac remodelling. Here, we aimed to develop radiolabeled activatable cell penetrating peptides (ACPP) sensitive to MT1-MMP for the detection of elevate
Externí odkaz:
https://doaj.org/article/bf38a488e05949f1815201f0c9d00d92
Autor:
Jules L Nelissen, Larry de Graaf, Willeke A Traa, Tom J L Schreurs, Kevin M Moerman, Aart J Nederveen, Ralph Sinkus, Cees W J Oomens, Klaas Nicolay, Gustav J Strijkers
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169864 (2017)
Deformation of skeletal muscle in the proximity of bony structures may lead to deep tissue injury category of pressure ulcers. Changes in mechanical properties have been proposed as a risk factor in the development of deep tissue injury and may be us
Externí odkaz:
https://doaj.org/article/1166259cbfc1471aa43ba92e9637c744
Autor:
Tom J L Schreurs, Stefanie J Hectors, Igor Jacobs, Holger Grüll, Klaas Nicolay, Gustav J Strijkers
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165759 (2016)
The aim of this study was to characterize response to photodynamic therapy (PDT) in a mouse cancer model using a multi-parametric quantitative MRI protocol and to identify MR parameters as potential biomarkers for early assessment of treatment outcom
Externí odkaz:
https://doaj.org/article/f95369ed8e7d4b149ed1201e799c19e7
Autor:
Geralda A.F. van Tilborg, Willem J.M. Mulder, Daisy W.J. van der Schaft, Chris P.M. Reutelingsperger, Arjan W. Griffioen, Gustav J. Strijkers, Klaas Nicolay
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 12, Pp 1459-1469 (2008)
Angiogenic, that is, newly formed, blood vessels play an important role in tumor growth and metastasis and are a potential target for tumor treatment. In previous studies, the αvβ3 integrin, which is strongly expressed in angiogenic vessels, has be
Externí odkaz:
https://doaj.org/article/4e7810f37d92445a944eb17a23b70a30
Autor:
Jacobus F.A. Jansen, Evi M.P. Lemmens, Gustav J. Strijkers, Jeanine J. Prompers, Olaf E.M.G. Schijns, M. Eline Kooi, Emile A.M. Beuls, Klaas Nicolay, Walter H. Backes, Govert Hoogland
Publikováno v:
Neurobiology of Disease, Vol 32, Iss 2, Pp 293-301 (2008)
Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in
Externí odkaz:
https://doaj.org/article/61969a4d672f4503b70ce86a811170ef
Autor:
Lucas W E Starmans, Rik P M Moonen, Erica Aussems-Custers, Mat J A P Daemen, Gustav J Strijkers, Klaas Nicolay, Holger Grüll
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119257 (2015)
Magnetic particle imaging (MPI) is an emerging medical imaging modality that directly visualizes magnetic particles in a hot-spot like fashion. We recently developed an iron oxide nanoparticle-micelle (ION-Micelle) platform that allows highly sensiti
Externí odkaz:
https://doaj.org/article/e1c47ee2c311436f91753d6096b95740
Autor:
Bastiaan J van Nierop, Noortje A M Bax, Jules L Nelissen, Fatih Arslan, Abdallah G Motaal, Larry de Graaf, Jaco J M Zwanenburg, Peter R Luijten, Klaas Nicolay, Gustav J Strijkers
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129899 (2015)
BACKGROUND:Myocardial fibrosis is a common hallmark of many diseases of the heart. Late gadolinium enhanced MRI is a powerful tool to image replacement fibrosis after myocardial infarction (MI). Interstitial fibrosis can be assessed indirectly from a
Externí odkaz:
https://doaj.org/article/2de087b769894143bedf8396f5eb1b9c
Autor:
Jean-Christophe Brisset, Benjamin A Hoff, Thomas L Chenevert, Jon A Jacobson, Jennifer L Boes, Stefanie Galbán, Alnawaz Rehemtulla, Timothy D Johnson, Kenneth J Pienta, Craig J Galbán, Charles R Meyer, Timothy Schakel, Klaas Nicolay, Ajjai S Alva, Maha Hussain, Brian D Ross
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123877 (2015)
Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overa
Externí odkaz:
https://doaj.org/article/4f5abe73610c40c2b93fec33f6a9b7b2
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100525 (2014)
Metformin is a widely prescribed drug for the treatment of type 2 diabetes. Previous studies have demonstrated in vitro that metformin specifically inhibits Complex I of the mitochondrial respiratory chain. This seems contraindicative since muscle mi
Externí odkaz:
https://doaj.org/article/5e6ecce7cfde4841a6cdae3d73e4a2cd
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99936 (2014)
PurposeIn this study endogenous magnetic resonance imaging (MRI) biomarkers for accurate segmentation of High Intensity Focused Ultrasound (HIFU)-treated tumor tissue and residual or recurring non-treated tumor tissue were identified.MethodsMultipara
Externí odkaz:
https://doaj.org/article/d8087782835e4d68881a92b461278c04