Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Klaas M, Pos"'
Autor:
Coline Plé, Heng-Keat Tam, Anais Vieira Da Cruz, Nina Compagne, Juan-Carlos Jiménez-Castellanos, Reinke T. Müller, Elizabeth Pradel, Wuen Ee Foong, Giuliano Malloci, Alexia Ballée, Moritz A. Kirchner, Parisa Moshfegh, Adrien Herledan, Andrea Herrmann, Benoit Deprez, Nicolas Willand, Attilio Vittorio Vargiu, Klaas M. Pos, Marion Flipo, Ruben C. Hartkoorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, the authors identify pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through allosteric inhibition of it
Externí odkaz:
https://doaj.org/article/2d5e83c99b5c4265bf969d47fed84ba5
Autor:
Alina Ornik-Cha, Julia Wilhelm, Jessica Kobylka, Hanno Sjuts, Attilio V. Vargiu, Giuliano Malloci, Julian Reitz, Anja Seybert, Achilleas S. Frangakis, Klaas M. Pos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Resistance-nodulation-cell division (RND)-type tripartite efflux pumps confer multidrug resistance to Gram-negative bacteria. Here, structural and functional analyses of AdeB from Acinetobacter baumannii and AcrB from Escherichia coli provide insight
Externí odkaz:
https://doaj.org/article/0fa39d64c8884cc2b68766a6f47a6795
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Gram-negative bacteria can display intrinsic antibiotic resistance due to the action of tripartite efflux pumps, which include a H+/drug antiporter component. Here, the authors present a structure-function analysis of antiporter AcrB in intermediate
Externí odkaz:
https://doaj.org/article/6482f47ba7254e868df9dbcc9afdc705
Autor:
Nina Compagne, Anais Vieira Da Cruz, Reinke T. Müller, Ruben C. Hartkoorn, Marion Flipo, Klaas M. Pos
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 180 (2023)
Antimicrobial resistance (AMR) has become a major problem in public health leading to an estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and repeated use of antibiotics has led to bacterial strains that are partial
Externí odkaz:
https://doaj.org/article/c36548178e0f4e1bb0879082e17f1a6c
Autor:
Manuela Sumyk, Stephanie Himpich, Wuen Ee Foong, Andrea Herrmann, Klaas M. Pos, Heng-Keat Tam
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Acinetobacter baumannii is an important nosocomial pathogen that requires thoughtful consideration in the antibiotic prescription strategy due to its multidrug resistant phenotype. Tetracycline antibiotics have recently been re-administered as part o
Externí odkaz:
https://doaj.org/article/7078066933ec4613b75534d886a22ae8
Publikováno v:
Antibiotics, Vol 10, Iss 12, p 1494 (2021)
Gram-negative Tripartite Resistance Nodulation and cell Division (RND) superfamily efflux pumps confer various functions, including multidrug and bile salt resistance, quorum-sensing, virulence and can influence the rate of mutations on the chromosom
Externí odkaz:
https://doaj.org/article/48773c4e68264ebea3ceeff8364d19a0
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Antibiotic efflux is one of the most critical mechanisms leading to bacterial multidrug resistance. Antibiotics are effluxed out of the bacterial cell by a tripartite efflux pump, a complex machinery comprised of outer membrane, periplasmic
Externí odkaz:
https://doaj.org/article/cf62dd8e3374478284349c2fc6b3abe6
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The AcrB module of the AcrAB-TolC multidrug efflux pump sequesters drugs from the periplasm and outer leaflet of the inner membrane. Here, Oswaldet al. provide evidence that lipophilic carboxylated substrates bind to a groove between transmembrane he
Externí odkaz:
https://doaj.org/article/fa3b0c6a09c14ed89a4c26f47061ebab
Publikováno v:
Biological Chemistry.
Substrate-binding proteins (SBPs) are part of solute transport systems and serve to increase substrate affinity and uptake rates. In contrast to primary transport systems, the mechanism of SBP-dependent secondary transport is not well understood. Fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::793c743e0f300d30b566afa33db9a995
https://doi.org/10.1515/hsz-2022-0337
https://doi.org/10.1515/hsz-2022-0337
Autor:
Laetitia Daury, François Orange, Jean-Christophe Taveau, Alice Verchère, Laura Monlezun, Céline Gounou, Ravi K. R. Marreddy, Martin Picard, Isabelle Broutin, Klaas M. Pos, Olivier Lambert
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Tripartite efflux systems consist of inner membrane, outer membrane and periplasmic components. Here, Daury et al. reconstitute native versions of RND transporters in nanodiscs and present projection structures emphasizing the role of the periplasmic
Externí odkaz:
https://doaj.org/article/eba793de8123457e92c40e3142a2ad4f