Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype.

Autor: Vieira V; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Lim N; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Singh A; Africa Health Research Institute, Durban, South Africa., Leitman E; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Dsouza R; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Adland E; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Muenchhoff M; Max von Pettenkofer-Institute, Department of Virology, Ludwig-Maximilians-University, Munich, Germany.; German Center for Infection Research, Munich, Germany., Roider J; German Center for Infection Research, Munich, Germany.; Department of Infectious Diseases, Ludwig-Maximilians-University, Munich, Germany., Marin Lopez M; IrsiCaixa AIDS Research Institute, Badalona, Spain., Carabelli J; IrsiCaixa AIDS Research Institute, Badalona, Spain., Giandhari J; KwaZulu-Natal Research Innovation and Sequencing Platform, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa., Groll A; Department of Statistics, TU Dortmund University, Dortmund, Germany., Jooste P; Department of Paediatrics, Kimberley Hospital, Kimberley, South Africa., Prado JG; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute, Badalona, Spain; Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain., Thobakgale C; Faculty of Health Sciences, Centre for HIV and STIs, National Institute for Communicable Diseases, University of the Witwatersrand, Johannesburg, South Africa.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa., Dong K; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA., Kiepiela P; South African Medical Research Council, Durban, South Africa.; Wits Health Consortium, Johannesburg, South Africa., Prendergast AJ; Blizard Institute, Queen Mary University of London, London, United Kingdom.; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Tudor-Williams G; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Frater J; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom., Walker BD; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA., Ndung'u T; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.; Division of Infection and Immunity, University College London, London, United Kingdom., Ramsuran V; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Leslie A; Africa Health Research Institute, Durban, South Africa.; Division of Infection and Immunity, University College London, London, United Kingdom.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Kløverpris HN; Africa Health Research Institute, Durban, South Africa.; Division of Infection and Immunity, University College London, London, United Kingdom.; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Goulder P; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.

Publikováno v: JCI insight [JCI Insight] 2023 Feb 08; Vol. 8 (3). Date of Electronic Publication: 2023 Feb 08.

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation.

Autor: Kummerlowe C; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mwakamui S; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia., Hughes TK; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mulugeta N; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mudenda V; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia., Besa E; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia., Zyambo K; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia., Shay JES; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Fleming I; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Vukovic M; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Doran BA; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Pathology, MGH, Harvard Medical School, Boston, MA 02115, USA., Aicher TP; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wadsworth MH 2nd; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Bramante JT; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Department of Pathology, MGH, Harvard Medical School, Boston, MA 02115, USA.; University of Washington School of Medicine, Seattle, WA 98195, USA., Uchida AM; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.; Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Fardoos R; Africa Health Research Institute, Durban 4001, South Africa., Asowata OE; Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA.; Africa Health Research Institute, Durban 4001, South Africa.; Center for Biomedical Research, Population Council, Rockefeller University, New York, NY 10065, USA., Herbert N; Africa Health Research Institute, Durban 4001, South Africa., Yilmaz ÖH; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Pathology, MGH, Harvard Medical School, Boston, MA 02115, USA., Kløverpris HN; Africa Health Research Institute, Durban 4001, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.; Department of Immunology and Microbiology, University of Copenhagen, 1017 Copenhagen K, Denmark.; University College London, Division of Infection and Immunity, London WC1E 6BT, UK., Garber JJ; Department of Pathology, MGH, Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Ordovas-Montañes J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Gartner ZJ; University of California San Francisco, San Francisco, CA 94185, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Wallach T; Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA., Shalek AK; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA., Kelly P; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia.; Blizard Institute, Queen Mary University of London, London E1 2AT, UK.

Publikováno v: Science translational medicine [Sci Transl Med] 2022 Aug 31; Vol. 14 (660), pp. eabi8633. Date of Electronic Publication: 2022 Aug 31.

HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells.

Autor: Fardoos R; Africa Health Research Institute, Durban, South Africa.; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Asowata OE; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Herbert N; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Nyquist SK; Institute for Medical Engineering & Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.; Program in Computational and Systems Biology, MIT, Cambridge, Massachusetts, USA., Zungu Y; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Singh A; Africa Health Research Institute, Durban, South Africa., Ngoepe A; Africa Health Research Institute, Durban, South Africa., Mbano IM; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Mthabela N; Africa Health Research Institute, Durban, South Africa., Ramjit D; Africa Health Research Institute, Durban, South Africa., Karim F; Africa Health Research Institute, Durban, South Africa., Kuhn W; ENT Department, General Justice Gizenga Mpanza Regional Hospital (Stanger Hospital), University of KwaZulu-Natal, Durban, South Africa., Madela FG; Discipline of General Surgery, Inkosi Albert Luthuli Central Hospital, University of KwaZulu-Natal, Durban, South Africa., Manzini VT; Discipline of General Surgery, Inkosi Albert Luthuli Central Hospital, University of KwaZulu-Natal, Durban, South Africa., Anderson F; Discipline of General Surgery, Inkosi Albert Luthuli Central Hospital, University of KwaZulu-Natal, Durban, South Africa., Berger B; Computer Science and Artificial Intelligence Laboratory and Department of Mathematics, MIT, Cambridge, Massachusetts, USA., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Shalek AK; Institute for Medical Engineering & Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA., Leslie A; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Division of Infection and Immunity, University College London, London, United Kingdom., Kløverpris HN; Africa Health Research Institute, Durban, South Africa.; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Division of Infection and Immunity, University College London, London, United Kingdom.

Publikováno v: JCI insight [JCI Insight] 2021 Aug 23; Vol. 6 (16). Date of Electronic Publication: 2021 Aug 23.

Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life.

Autor: Attaf M; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.; Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom., Roider J; Human Immunodeficiency Virus Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Africa Health Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; German Centre for Infection Research, Munich, Germany.; Department of Infectious Diseases, Ludwig-Maximilians-University, Munich, Germany., Malik A; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Rafael CR; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.; Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom., Dolton G; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.; Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom., Prendergast AJ; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.; Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, United Kingdom.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Leslie A; Africa Health Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Infection and Immunity, University College London, London, United Kingdom., Ndung'u T; Human Immunodeficiency Virus Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Africa Health Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Infection and Immunity, University College London, London, United Kingdom.; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA, United States.; Virology and Immunology, Max Planck Institute for Infection Biology, Berlin, Germany., Kløverpris HN; Africa Health Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Infection and Immunity, University College London, London, United Kingdom., Sewell AK; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.; Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom., Goulder PJ; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Dec 21; Vol. 11, pp. 633633. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020).

Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy.

Autor: Singh A; Africa Health Research Institute (AHRI), Durban 4001, South Africa., Kazer SW; Institute for Medical Engineering and Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Ragon Institute of MGH, Harvard, and MIT, Cambridge, MA 02139., Roider J; Africa Health Research Institute (AHRI), Durban 4001, South Africa; Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, UK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban 4001, South Africa; Medizinische Klinik IV, Department of Infectious Diseases, Ludwig-Maximilians-University, Munich 80802, Germany., Krista KC; Institute for Medical Engineering and Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Ragon Institute of MGH, Harvard, and MIT, Cambridge, MA 02139., Millar J; Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, UK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban 4001, South Africa., Asowata OE; Africa Health Research Institute (AHRI), Durban 4001, South Africa., Ngoepe A; Africa Health Research Institute (AHRI), Durban 4001, South Africa., Ramsuran D; Africa Health Research Institute (AHRI), Durban 4001, South Africa., Fardoos R; Africa Health Research Institute (AHRI), Durban 4001, South Africa; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200N, Denmark., Ardain A; Africa Health Research Institute (AHRI), Durban 4001, South Africa; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4001, South Africa., Muenchhoff M; Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, UK; Max von Pettenkofer Institute, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich 81377, Germany; German Center for Infection Research (DZIF), partner site Munich 80333, Germany., Kuhn W; ENT Department General Justice Gizenga Mpanza Regional Hospital (Stanger Hospital), University of KwaZulu-Natal, Durban 4001, South Africa., Karim F; Africa Health Research Institute (AHRI), Durban 4001, South Africa., Ndung'u T; Africa Health Research Institute (AHRI), Durban 4001, South Africa; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban 4001, South Africa; University College London, Division of Infection and Immunity, London WC1E 6AE, UK; Max Planck Institute for Infection Biology, Berlin 10117, Germany., Shalek AK; Institute for Medical Engineering and Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Ragon Institute of MGH, Harvard, and MIT, Cambridge, MA 02139., Goulder P; Africa Health Research Institute (AHRI), Durban 4001, South Africa; Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, UK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban 4001, South Africa., Leslie A; Africa Health Research Institute (AHRI), Durban 4001, South Africa; University College London, Division of Infection and Immunity, London WC1E 6AE, UK; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4001, South Africa., Kløverpris HN; Africa Health Research Institute (AHRI), Durban 4001, South Africa; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200N, Denmark; University College London, Division of Infection and Immunity, London WC1E 6AE, UK; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. Electronic address: henrik.kloverpris@ahri.org.

Publikováno v: Cell reports [Cell Rep] 2020 Sep 15; Vol. 32 (11), pp. 108153.