Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Klára Konečná"'
Autor:
Martin Krátký, Klára Konečná, Ondřej Janďourek, Adéla Diepoltová, Pavlína Vávrová, Barbora Voxová, Marcela Vejsová, Pavel Bárta, Szilvia Bősze
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT In this study, we have focused on a multiparametric microbiological analysis of the antistaphylococcal action of the iodinated imine BH77, designed as an analogue of rafoxanide. Its antibacterial activity against five reference strains and e
Externí odkaz:
https://doaj.org/article/cf270161215c4616bea6e52739e204f5
Autor:
Klára Konečná, Adéla Diepoltová, Pavlína Holmanová, Ondřej Jand’ourek, Marcela Vejsová, Barbora Voxová, Pavel Bárta, Jana Maixnerová, František Trejtnar, Marta Kučerová-Chlupáčová
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The greatest threat and medicinal impact within gram-positive pathogens are posed by two bacterial genera, Staphylococcus and Enterococcus. Chalcones have a wide range of biological activities and are recognized as effective templates in medicinal ch
Externí odkaz:
https://doaj.org/article/4da402bc3a974b44916136f26d267479
Autor:
Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 384 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/aa4e4ec8b1be476ba24f0f7a8a0e83ab
Autor:
Petr Šlechta, Adam Anthony Needle, Ondřej Jand’ourek, Pavla Paterová, Klára Konečná, Pavel Bárta, Jiří Kuneš, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2951 (2023)
Tuberculosis remains a serious killer among infectious diseases due to its incidence, mortality, and occurrence of resistant mycobacterial strains. The challenge to discover new antimycobacterial agents forced us to prepare a series of N-(1-hydroxy-1
Externí odkaz:
https://doaj.org/article/4fa4428dfe1442afbe0a7f273e8e7758
Autor:
Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 133 (2022)
The current study is focused on the combination of pyrazinamide with 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol, which is a crucial pharmacophore of several antimicrobial agents. The use of benzoxaborole moiety could afford the formation of a spiro adduct
Externí odkaz:
https://doaj.org/article/e25ce61262bb44ff81190f948987b53c
Autor:
Vinod Sukanth Kumar Pallabothula, Marek Kerda, Martin Juhás, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Pavla Paterová, Jan Zitko
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1561 (2022)
Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such earned its place on the WHO list of priority pathogens. New antimycobacterials with a mechanism of action different to currently used agents are highly requir
Externí odkaz:
https://doaj.org/article/8407d76be4d84611821259c8a5fa6dd2
Autor:
Viriyanata Wijaya, Ondřej Janďourek, Jana Křoustková, Kateřina Hradiská-Breiterová, Jan Korábečný, Kateřina Sobolová, Eliška Kohelová, Anna Hošťálková, Klára Konečná, Marcela Šafratová, Rudolf Vrabec, Jiří Kuneš, Lubomír Opletal, Jakub Chlebek, Lucie Cahlíková
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 844 (2022)
Tuberculosis (TB) is a widespread infectious disease caused by Mycobacterium tuberculosis. The increasing incidence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has created a need for new antiTB agents with new chemical s
Externí odkaz:
https://doaj.org/article/7d7edd4993bd478abebcbfeee939312a
Autor:
Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 580 (2022)
Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug can
Externí odkaz:
https://doaj.org/article/272fa446ccac49b29f63ff1088d904e1
Autor:
Na Cai, Monika Fňašková, Klára Konečná, Miloslava Fojtová, Jiří Fajkus, Eve Coomber, Stephen Watt, Nicole Soranzo, Marek Preiss, Ivan Rektor
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Mitochondrial DNA copy number has been previously shown to be elevated with severe and chronic stress, as well as stress-related pathology like Major Depressive Disorder (MDD) and post-traumatic stress disorder (PTSD). While experimental data point t
Externí odkaz:
https://doaj.org/article/1860d094a87c42f0aafebd8c70674cc9
Autor:
Martin Krátký, Šárka Štěpánková, Klára Konečná, Katarína Svrčková, Jana Maixnerová, Markéta Švarcová, Ondřej Janďourek, František Trejtnar, Jarmila Vinšová
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1229 (2021)
A series of thirty-one hydrazones of aminoguanidine, nitroaminoguanidine, 1,3-diaminoguanidine, and (thio)semicarbazide were prepared from various aldehydes, mainly chlorobenzaldehydes, halogenated salicylaldehydes, 5-nitrofurfural, and isatin (yield
Externí odkaz:
https://doaj.org/article/fcac6a015aab4e599dcb6c73d4149617