Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Klára Kirsch"'
Autor:
András Zeke, Tamás Takács, Péter Sok, Krisztina Németh, Klára Kirsch, Péter Egri, Ádám Levente Póti, Isabel Bento, Gábor E. Tusnády, Attila Reményi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this en
Externí odkaz:
https://doaj.org/article/f6d3c3032ebe40f894a83f92cc0e664c
Autor:
Klára Kirsch, András Zeke, Orsolya Tőke, Péter Sok, Ashish Sethi, Anna Sebő, Ganesan Senthil Kumar, Péter Egri, Ádám L. Póti, Paul Gooley, Wolfgang Peti, Isabel Bento, Anita Alexa, Attila Reményi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphor
Externí odkaz:
https://doaj.org/article/8e3a384b4b1a49a98424465168b5b1a6
Autor:
Wolfgang Peti, Attila Reményi, Klára Kirsch, Isabel Bento, Péter Egri, Anita Alexa, Ganesan Senthil Kumar, Orsolya Tőke, Ashish Sethi, Péter Sok, András Zeke, Paul R. Gooley, Anna Sebő, Ádám Póti
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications 11(1), 5769 (2020). doi:10.1038/s41467-020-19582-3
Nature Communications
Nature Communications 11(1), 5769 (2020). doi:10.1038/s41467-020-19582-3
Nature Communications
Nature Communications 11(1), 5769 (2020). doi:10.1038/s41467-020-19582-3
Transcription factor phosphorylation at specific sites often activates gene expression, but how environmental cues quantitatively control transcription is not well-understo
Transcription factor phosphorylation at specific sites often activates gene expression, but how environmental cues quantitatively control transcription is not well-understo
Autor:
Mariana Shumliakivska, Guillermo Luxán, Inga Hemmerling, Marina Scheller, Xue Li, Carsten Müller-Tidow, Bianca Schuhmacher, Zhengwu Sun, Andreas Dendorfer, Alisa Debes, Simone-Franziska Glaser, Marion Muhly-Reinholz, Klara Kirschbaum, Jedrzej Hoffmann, Eike Nagel, Valentina O. Puntmann, Sebastian Cremer, Florian Leuschner, Wesley Tyler Abplanalp, David John, Andreas M. Zeiher, Stefanie Dimmeler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Hematopoietic mutations in epigenetic regulators like DNA methyltransferase 3 alpha (DNMT3A), play a pivotal role in driving clonal hematopoiesis of indeterminate potential (CHIP), and are associated with unfavorable outcomes in patients suf
Externí odkaz:
https://doaj.org/article/20a09696ec974f6db501fff88d7fff78
Autor:
Wolfgang Peti, Zoltán Gáspári, Klára Kirsch, Ganesan Senthil Kumar, Anita Alexa, Neha Singh, Gergő Gógl, László Drahos, Attila Reményi, Anna Sebő, Péter Sok
Publikováno v:
Structure
Mitogen-activated protein kinases (MAPKs) control essential eukaryotic signaling pathways. While much has been learned about MAPK activation, much less is known about substrate recruitment and specificity. MAPK substrates may be other kinases that ar
Autor:
Zoltán Gáspári, Anna Sebő, László Drahos, Gergő Gógl, Ganesan Senthil Kumar, Attila Reményi, Péter Sok, Anita Alexa, Neha Singh, Klára Kirsch, Wolfgang Peti
Publikováno v:
SSRN Electronic Journal.
Mitogen activated protein kinases (MAPKs) control essential eukaryotic signaling pathways. While much has been learned about MAPK activation, much less is known about substrate recruitment and specificity. MAPK substrates may be other kinases that ar
Autor:
Jong Il Ahn, Liang Zhang, Harsha Ravishankar, Lixin Fan, Klara Kirsch, Yan Zeng, Lingjun Meng, Jung-Eun Park, Hye-Yeoung Yun, Rodolfo Ghirlando, Buyong Ma, David Ball, Bonsu Ku, Ruth Nussinov, Jeremy D. Schmit, William F. Heinz, Seung Jun Kim, Tatiana Karpova, Yun-Xing Wang, Kyung S. Lee
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/4954415703224bd39f8ad4b7d54ac61c
Autor:
Jong Il Ahn, Liang Zhang, Harsha Ravishankar, Lixin Fan, Klara Kirsch, Yan Zeng, Lingjun Meng, Jung-Eun Park, Hye-Yeoung Yun, Rodolfo Ghirlando, Buyong Ma, David Ball, Bonsu Ku, Ruth Nussinov, Jeremy D. Schmit, William F. Heinz, Seung Jun Kim, Tatiana Karpova, Yun-Xing Wang, Kyung S. Lee
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-20 (2023)
Abstract Proper organization of intracellular assemblies is fundamental for efficient promotion of biochemical processes and optimal assembly functionality. Although advances in imaging technologies have shed light on how the centrosome is organized,
Externí odkaz:
https://doaj.org/article/06aa6e8547484fe7b186bef73965f8dc
Publikováno v:
Advanced Technologies for Protein Complex Production and Characterization ISBN: 9783319272146
Signaling complexes within the cell convert extracellular cues into physiological outcomes. Their assembly involves signaling enzymes, allosteric regulators and scaffold proteins that often contain long stretches of disordered protein regions, displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a935ffcacb177624b62dcc7d1b4aacaf
https://doi.org/10.1007/978-3-319-27216-0_20
https://doi.org/10.1007/978-3-319-27216-0_20
Autor:
András Zeke, Attila Reményi, Zsuzsanna Dosztányi, Bálint Mészáros, Olga V. Kalinina, Klára Kirsch, Anita Alexa, Tomas Bastys, Ágnes Garai
Publikováno v:
Molecular Systems Biology
ResearcherID
ResearcherID
Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling. However, how these enzymes can be involved in such a broad spectrum of physiological functions is not understood. Systematic discovery of MAPK networks both